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Reduction in stress cracking of films

a film and stress cracking technology, applied in the field of film stress cracking reduction, can solve the problems of film sticks, not being able to move to relieve stress, etc., and achieve the effect of reducing or substantially reducing the stress cracking of polymers and lowering the surface energy of packaging materials

Inactive Publication Date: 2014-09-18
AQUESTIVE THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides methods for reducing stress cracking of polymers in film products that contain an active ingredient, such as pharmaceutical actives. The methods involve lowering the surface energy of the packaging materials or annealing the film prior to storing it in a package. These methods help to improve the stability and shelf life of the film products, which can make them more reliable and useful in various applications.

Problems solved by technology

Sporadic events of stress cracking in polymeric based film strips found in finished products but not observed in a 15 minute in-process check or AQL testing has been an issue with some polymeric based film products.
Data analysis on lots exhibiting cracking has led to the conclusion that the problem is probably caused by imparting stress to the strips during the manufacturing process.
When the strip is individually packaged in a material with a high surface energy, the film sticks to the packaging material and is not allowed to move to relieve the stresses.

Method used

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  • Reduction in stress cracking of films
  • Reduction in stress cracking of films
  • Reduction in stress cracking of films

Examples

Experimental program
Comparison scheme
Effect test

example 1

Comparative Testing Between Two Materials

[0098]Two materials were tested for peel force using a load frame and packaging tape. The first material (“Material A”) was a packaging product having a surface made from ethylene acrylic acid, and the second material (“Material B”) was a packaging product having a surface made from LDPE. FIG. 1 demonstrates the foil film peel test results for these two materials.

[0099]Test samples were one inch wide. The ends of the tape and the substrate films were clamped by grips of an MTS load frame. The tests were run at 2 inches per minute speed. The load rises as the specimen ends are pulled until the sample is taught and peeling progresses. Once peeling is initiated, the load is variable based on the local bond strength between packaging tape and the substrate film. The data became more stable after a moderate opening length, and the test data was averaged over on opening distance of 0.75 inches to 1.75 inches.

[0100]Water contact angle tests were the...

example 2

Comparative Testing

[0105]Two lots of film product, both including PEO as a polymeric component, were manufactured and packaged in two separate packaging materials. The first packaging material included an inner surface made from ethylene acrylic acid and the second packaging material included an inner surface made from LDPE. These lots were inspected after 20 weeks for stress cracked strips.

[0106]After twenty weeks, the first lot packaged in the ethylene acrylic acid packaging showed 30.4% stress cracking, and the first lot packaged in the LDPE packaging showed 4.2% stress cracking. Also after twenty weeks, the second lot packaged in the ethylene acrylic acid packaging showed 46.4% stress cracking, and the first lot packaged in the LDPE packaging showed 0% stress cracking.

example 3

Use of LDPE Packaging Material

[0107]Five lots of film material, each including PEO as a polymeric component, were packaged in a packaging material including an inner surface made from LDPE and placed in a 36 month stability program. The samples were stored at either 25° C. or 30° C. At the end of the 36 months, samples were inspected for stress cracking. The results are presented in Table 2 below:

TABLE 2Stress cracking after 36 months storageat different temperature conditions.Storage temperaturePercentage withLot No.Number of Samples(° C.)Stress Cracking125250%225250%325250%425250%525250%125300%225300%325300%425300%525300%

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Abstract

Methods and packages for storing film strips while reducing or eliminating stress cracking during storage, including use of packages having an inner surface made from polymeric materials exhibiting various physical properties and including films and pouches that are annealed.

Description

FIELD OF THE INVENTION[0001]The present invention relates to methods and packages for storing film strips while reducing or eliminating stress cracking during storage.BACKGROUND OF THE INVENTION[0002]Sporadic events of stress cracking in polymeric based film strips found in finished products but not observed in a 15 minute in-process check or AQL testing has been an issue with some polymeric based film products. Stress cracking generally begins to appear in the film product 2 to 4 weeks after manufacturing and packaging. Data analysis on lots exhibiting cracking has led to the conclusion that the problem is probably caused by imparting stress to the strips during the manufacturing process.[0003]One source of stress that is imparted to the film during manufacturing is in the drying process. During drying, the wet film product is applied or coated to a substrate, and is then dried on that substrate. In some drying processes, particularly those including high solvent content, up to 70%...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B65D33/00
CPCB65D33/002A61J1/00C08J5/18A61K9/7007B65D75/00A61K47/00A61J1/035Y10T428/1334
Inventor BOGUE, BEUFORD ARLIESLOMINSKI, GREG
Owner AQUESTIVE THERAPEUTICS INC
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