Use of Chemotherapeutic Agents

Abstract

The use of chemotherapeutic agents for the preparation of a medicament for the topical and / or local treatment of diseases caused by bacteria and / or for prophylaxis in humans or animals.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a Divisional of U.S. Ser. No. 11 / 619,823 (filed Jan. 4, 2007), which is a Divisional of U.S. Ser. No. 10 / 168,441 (filed Jun. 21, 2002), which is a National Phase 371 filing of International Application No. PCT / EP00 / 13155 (filed Dec. 22, 2002), which claims priority to DE 19962470.4 (filed Dec. 22, 1999), the contents of which are incorporated herein by reference in their entireties.BACKGROUND[0002]1. Field of the Invention[0003]The present invention relates to the use of chemotherapeutic agents for the preparation of a medicament for the topical and / or local treatment of diseases caused by bacteria and / or for prophylaxis in humans or animals.[0004]2. Description of Related Art[0005]Bacteria can be the cause of a large number of diseases and can moreover impair wound healing. In the oral region, for example, tooth decay (caries) is caused by microbes specific to the mouth. Oral bacteria convert dietary carbohydrates to ...

AI Technical Summary

Benefits of technology

These compounds effectively treat and prevent bacterial infections in the oral region and wounds by achieving high concentrations locally, accelerating wound healing, and preserving teeth, while minimizing resistance and systemic burden, offering a rapid and effective solution for both dental and veterinary applications.

Problems solved by technology

Bacteria can be the cause of a large number of diseases and can moreover impair wound healing.

As the pulp is located in the rigid pulp cavity, it cannot expand and pain occurs.

If the situation is left untreated, the consequences are necrosis of the pulp tissue and bacterial decomposition (gangrene).

If the gangrenous matter is not removed, this is followed by inflammations outside the root tip.

The consequences are continued destruction of the bones and loosening of the teeth, which ultimately fall out.

Damage in the oral region can also lead to diseases in other body organs.

If the pulp is gangrenous, success can only be expected if the contaminated root canal system and the dentin near the canal can be disinfected.

The main problems are the inaccessibility of the bacterially infected apical delta of the root canals, which is difficult to clean, and also the infected canal wall system, which has to be removed with considerable effort using instruments.

The substances of synthetic origin are less valuable in dental medicine.

According to the prevailing school of thought, they are frequently characterized by high costs, lack of efficacy and toxicity for the patient.

The therapeutic benefit is generally also limited in wounds with adequate external drainage.

The substances used are scarcely absorbed, if at all, so their action cannot be expected to penetrate deeper into the tissue.

Wounds are dangerous inter alia because of possible infections due to penetration by pathogenic bacteria.

Bacterial colonization of the wound can slow down or prevent the healing process or lead to other complications such as lymphangitis, sepsis or chronic infections.

In many cases wound infections can be successfully treated by the administration of systemically active antibiotics, but the systemic administration of an antibiotic necessarily burdens the entire organism.

However, the use of topical antibiotics is not generally recommended because this can lead to allergic reactions or to the formation of antibiotic-resistant species of bacteria.

A local application is unsuccessful in the case of deep skin infections because the antibiotics do not penetrate the intact skin.

However, with the presence of local or systemic toxicity and the danger of the secondary development of bacterial resistance, local antibiotics should only be used with great restraint.

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