Automatic injection device

a technology of injection device and injection needle, which is applied in the field of automatic injection device, can solve the problems of delay in treatment and fear of puncture pain, and achieve the effects of reducing the pain of puncture, reducing the impact of puncture, and alleviating anxiety and fear of patients

Inactive Publication Date: 2015-06-04
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0028]According to the present invention, in automatically performing puncture, conditions of the puncture can be set according to the thickness of a syringe needle, the puncture depth, and so forth. This reduces pain in the puncture and reduces the impact in the puncture, allowing alleviation of anxiety and fear of a patient.
[0029]Furthermore, according to a preferred mode of the present invention, the puncture speed in puncture by the first drive unit satisfies 10 to 500 mm / s when the thickness of the syringe needle is in a range of 18 G to 34 G. This can automatically perform puncture with very little pain of the puncture at such a puncture speed as to yield almost no pain.

Problems solved by technology

However, a drug solution is infused through puncture by the syringe needle and thus this method involves pain when the needle penetrates the skin.
Therefore, in some cases, fear of the pain when puncture by a syringe needle is performed and discomfort in infusion of a drug solution is caused in a patient to which the drug solution is administered by using a syringe and the patient refuses the drug treatment or becomes negative about it.
This leads to delay in the treatment.
In particular, diabetes patients for which insulin injection is necessary and patients with growth deficiency for which growth hormone injection is necessary are frequently children, and the pain and discomfort in injection are also a cause of later “injection phobia” (Needle phobia).

Method used

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Examples

Experimental program
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Effect test

working examples

[0152]Next, the range of a preferred puncture speed will be described in more detail by using working examples.

[0153]The inventors of the present application have found that following facts. Specifically, in puncture by a syringe needle, the penetration resistance decreases depending on the puncture speed. In addition, suppression of the pain response is found in rat electromyography and the pain response evoked by puncture disappears if the puncture speed is higher than a certain puncture speed. Although what kind of behavior causes such an effect in pain sensing nerves of the skin is unclear, due to the high-speed puncture, an action potential would not be generated in the Na ion channel, the Ca ion channel, and so forth to transmit excitement for stimulating nerve terminals that are the pain sensing nerves of the skin.

[0154]Therefore, the inventors of the present application made a puncture device that could perform puncture similar to that by the automatic injection device 10 an...

working example 1

[0160]As working example 1, puncture was performed in the plantar regions of rats by using the puncture device 100.

[0161]The puncture speed of the puncture device 100 was set to 3 mm / s. The puncture depth was set to 3 mm. The stop time was set to two seconds. The withdrawal speed was set to 20 mm / s.

[0162]Furthermore, as the syringe needle 74, a syringe needle with a thickness of 27 G (27 G Neolus needle φ0.40×19 mm, made by Terumo Corporation) was used.

[0163]In addition, the distance between the tip of the syringe needle 74 before operation start and a puncture site was set to 3 mm. That is, a configuration in which the puncture device 100 made the syringe needle advance by 6 mm was employed.

[0164]Moreover, as the rats of the puncture subject, 7- to 8-week-old SD male rats were purchased from Charles River Laboratories Japan, Inc. and were used for the experiment after an acclimatization period of one week was set. The weights of the animals at the time of the experiment were 273 g ...

working example 2

[0181]Except for that the puncture speed was changed to 15 mm / s, the penetration resistance and the EMG response magnitude were obtained similarly to working example 1.

[0182]The resistance value at the timing when the puncture with the syringe needle 74 ended (puncture depth was 3 mm) (arrow z) is shown in FIG. 8(A) and the EMG response magnitude (Total Power) is shown in FIG. 8(B).

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Abstract

An object of the present invention is to provide an automatic injection device that allows setting of conditions of puncture according to the thickness of a syringe needle, the puncture depth, and so forth to reduce pain in the puncture and reduce the impact in the puncture to allow alleviation of anxiety and fear of a patient. An automatic injection device of the present invention has a syringe holder that holds a syringe attachably and detachably, a first drive unit that causes the syringe holder holding the syringe to advance to perform puncture by a syringe needle, and a control unit that controls the first drive unit to control the puncture speed.

Description

TECHNICAL FIELD[0001]The present invention relates to an automatic injection device for moving a syringe held in the main body at a high speed to automatically perform puncture / injection.BACKGROUND ART[0002]Presently, as medicaments, use of protein preparations such as molecular targeting drugs, vaccines, and hormonal agents typified by insulin rapidly increases, and a device capable of easy administration of these medicaments is required. These medicaments are a high-molecular protein or peptide and are not absorbed into a body through oral administration. Therefore, administration by a syringe needle into a hypodermis or blood vessel is necessary.[0003]Administration by a syringe needle, such as hypodermic, intravenous, and intramuscular administrations, is a general administration method presently. However, a drug solution is infused through puncture by the syringe needle and thus this method involves pain when the needle penetrates the skin. Therefore, in some cases, fear of the...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M5/158A61M5/46A61M5/172A61M5/145
CPCA61M5/158A61M5/1452A61M2005/1585A61M5/172A61M2205/103A61M5/46A61M5/20A61M5/482A61M2005/206A61M2005/31588A61M2205/50A61B5/4848A61B2503/40A61B2503/42A61M5/31546A61M5/326A61B5/389A61B5/395A61B5/4827
Inventor OKAMOTO, KAZUOAMI, NOZOMIISOZAKI, TADAKATSUKURIHARA, DAICHI
Owner TERUMO KK
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