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Methods and devices for providing information useful in the diagnosis of abnormalities of the gastrointestinal tract

a technology of gastrointestinal tract abnormality and information, applied in the field of medical diagnosis, can solve the problems of complex and expensive cameras, disadvantages and high cost of ingestible imaging devices

Inactive Publication Date: 2015-07-02
TEL HASHOMER MEDICAL RES INFRASTRUCTURE & SERVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent is about methods and devices for diagnosing gastrointestinal abnormalities by using light to determine the intensity of light reflected from the intestinal wall. This technology can provide information without the need for an image, making it easier to diagnose abnormalities. The device used for this method is an ingestible capsule with a light projector and a light-detector assembly. The technical effect of this invention is improved diagnosis of gastrointestinal abnormalities.

Problems solved by technology

Such ingestible imaging devices have disadvantages.
Ingestible imaging devices are expensive, requiring complex and expensive cameras and often requiring small moving parts such as lenses in order to acquire diagnostically-useful images.
Ingestible imaging devices have high power requirements for operating the camera and an illumination source bright enough to allow acquisition of the images.
The camera of such imaging devices is necessarily directed parallel to the lumen but has limited field of view of the intestinal wall where gastrointestinal abnormalities are located.
Furthermore, ingestible imaging devices produce large amounts of image (video) data.
As a result, data acquisition and transmission is not trivial, must be performed continuously and requires a significant amount of power.
The large amount of data cannot be reviewed automatically and instead requires a time-consuming review by a skilled health-care professional, a factor that raises the cost of using such devices.
Even the most highly skilled health-care professional is only able to identify relatively large abnormalities that are visible under the poor intraluminal lighting conditions so that small abnormalities and abnormalities that have certain colors often remain undetected.

Method used

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  • Methods and devices for providing information useful in the diagnosis of abnormalities of the gastrointestinal tract
  • Methods and devices for providing information useful in the diagnosis of abnormalities of the gastrointestinal tract
  • Methods and devices for providing information useful in the diagnosis of abnormalities of the gastrointestinal tract

Examples

Experimental program
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Effect test

example 1

Wavelength Dependence of Diffuse Reflection from Normal and Abnormal Tissue

[0202]The wavelength dependence of diffuse reflection from the intestinal abnormalities of blood and invasive adenocarcinoma relative to normal intestinal mucosa was examined in a manner simulating the use of an ingestible device as described herein.

[0203]Two freshly excised samples (about 20 cm by 40 cm) of human intestinal tissue were provided, one with a bleeding area and one having an invasive adenocarcinoma, as determined by a pathologist.

[0204]As an illuminator, a 0.6 mm diameter glass fiber was connected to an SE NET Model 1-150 fiber optic light source including a 150 Watt Quartz halogen lamp and the distal tip of the fiber contacted with an area of intestinal tissue. As a light-detection assembly, a 0.2 mm diameter glass fiber was connected to a StellarNet Green Fiberoptic spectrometer (StellarNet, Inc, Tampa, Fla., USA) and the distal tip contacted with the intestinal tissue, 0.2 mm from the illumin...

example 2

Wavelength Dependence of Diffuse Reflection from Normal and Abnormal Tissue

[0208]The wavelength dependence of diffuse reflection from various intestinal abnormalities related to invasive adenocarcinoma relative to normal intestinal mucosa were examined in a manner simulating the use of an ingestible device as described herein.

[0209]Fifty-four in vivo spectral measurements were performed during standard colonoscopy in patients having various abnormalities as determined by a physician (endoscopist) and confirmed by a pathologist.

[0210]As an illuminator, a standard light source (xenon arc lamp) of endoscopic system (Olympus CV180, Olympus, Japan) was used. Light was directed at intestinal tissue to illuminate the entire surface of the tissue. A light-detection assembly includes a 600g (0.6 mm) diameter glass fiber connected to a StellarNet Green Fiberoptic spectrometer (StellarNet, Inc, Tampa, Fla., USA) as described in Example 1. As the distal tip of the light detection glass fiber co...

example 3

Wavelength Dependence of Diffuse Reflection from Normal and Abnormal Tissue

[0214]The wavelength dependence of diffuse reflection from various intestinal abnormalities relative to normal intestinal mucosa was examined in a manner simulating the use of an ingestible device as described herein.

[0215]45 freshly excised samples (about 20 cm by 40 cm) of human intestinal tissue were provided, having various abnormalities as determined by a pathologist.

[0216]As an illuminator, a quartz halogen lamp with polarizing filter was directed at a sample of intestinal tissue to illuminate the entire surface of the tissue. A spectral camera (SD-300 from Applied Spectral Imaging, Migdal Haemek, Israel) with a polarizing filter oriented perpendicularly to the polarizing filter of the illuminator was used as a light-detection assembly with the objective lens positioned 10 cm from a tissue sample surface to acquire spectra using the polarized-gated method between 400 nm and 800 nm at increments of 1 nm ...

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Abstract

Disclosed are methods useful for providing information useful in the diagnosis of gastrointestinal abnormalities as well as ingestible devices useful for providing information useful in the diagnosis of gastrointestinal abnormalities.

Description

RELATED APPLICATION[0001]The present application gains priority from U.S. Provisional Patent Application No. 61 / 434,566 filed 20 Jan. 2011 and U.S. 61 / 440,932 filed 9 Feb. 2011. The present application is also related to PCT / IB2010 / 053539 having an international filing date of 4 Aug. 2010 that gains priority from U.S. Provisional Patent Application No. 61 / 231,350 filed 5 Aug. 2009, both which are included by reference as if fully set forth herein.FIELD AND BACKGROUND OF THE INVENTION[0002]The invention, in some embodiments, relates to the field of medical diagnosis, and more particularly but not exclusively, to methods and devices for providing information useful in the diagnosis of abnormalities of the gastrointestinal tract (gastrointestinal abnormalities).[0003]Ingestible imaging devices for inspecting the gastrointestinal tract are known, for example the Pillcam™ available from Given Imaging (Yokneam, Israel). Such capsule-shaped devices generally include an illumination source ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/00
CPCA61B5/6861A61B5/4255A61B5/0084A61B1/041A61B5/0059A61B5/42
Inventor KOSTENICH, GENADYORENSTEIN, ARIE
Owner TEL HASHOMER MEDICAL RES INFRASTRUCTURE & SERVICES