Disease progression parameters and uses thereof for evaluating multiple sclerosis

a disease progression and disease technology, applied in the field of disease progression parameters, can solve the problems of reduced ability to remyelinate, loss of trophic factors supporting neurons and axons, and damage to nerve fibers, so as to improve the response to worsening, improve the scoring accuracy and consistency, and increase sensitivity
US20150220693A1Inactive Publication Date: 2015-08-06BIOGEN MA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BIOGEN MA INC
Publication Date
2015-08-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods, systems and kits to detect and / or quantify disease progression in a subject having a progressive form of MS are disclosed.
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Description

RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Application No. 61 / 682,521, filed Aug. 13, 2012, the contents of which are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION

[0002] Multiple sclerosis (MS) is an inflammatory disease of the brain and spinal cord characterized by recurrent foci of inflammation that lead to destruction of the myelin sheath. In many areas, nerve fibers are also damaged. Inflammatory activity in MS patients tends to be highest in the initial phase of disease.

[0003] Emerging data demonstrate that irreversible axonal loss occurs early in the course of MS. Transected axons fail to regenerate in the central nervous system (CNS) and therefore, early treatment aimed at suppressing MS lesion formation is of paramount importance. As early as disease onset, axons are transected in lesions with active inflammation (Trapp et al. (1998) N Engl J Med 338: 278-285; Bjartmar et al. (2001) Curr Opin Neurol 14: 27...

Claims

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