Device for electrochemically releasing a composition in a controlled manner
a technology of electrochemical release and composition, which is applied in the direction of electrical circuits, manufacturing tools, and therapy, can solve the problems of ineffective diffusion of composition towards the zone to be treated, the active control of composition release, and the lack of efficiency of the system of u.s. pat. no. 4,585,652
Inactive Publication Date: 2015-08-27
SORIN CRM
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- Description
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- Application Information
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Benefits of technology
The invention is a device that can control the release of a composition from an electroactive polymer at a specific location in the body. This device allows for better control over the quantity and timing of the released composition. It uses electrical means to apply a controlled signal to the working electrode, resulting in a higher degree of precision compared to other techniques. The electroactive polymer can be recharged and the device is preferably implantable in a mammal body. The device can also stimulate nerves or living tissues when the composition is released. Overall, the invention provides a more efficient and controlled way to release compositions in the body.
Problems solved by technology
The active control of the release of a composition, in terms of time, quantity and accuracy of delivery, remains a big challenge.
Hence, the composition cannot efficiently diffuse towards a zone to be treated.
In other words, the system of U.S. Pat. No. 4,585,652 lacks efficiency.
Second, the pulses of the potential time square wave (of positive or negative polarity) have a rather long duration.
In the examples given in this patent, these pulses are applied between a time equal to or longer than 1 s. When applied to living tissues, such long voltage pulses can lead to undesirable activation of excitable tissues close to the electrode comprising the polymer.
Such a system does not allow one to have a good and precise control on the quantity of composition that is released.
In particular, due to typical inhomogeneous ionic concentration, this short-circuit will allow the release of the composition to go on according to an uncontrolled manner, when no release of the composition is normally wanted.
Method used
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Definitions
[0042]The term “composition” as used herein is a set composed of various substances whose quantities are controlled, preferably biocompatible substances.
[0043]The term “voltametric pulse” as used herein is defined as a pulse of given voltage and given duration between a working 30 and a reference 60 electrodes, resulting from a voltage pulse or current pulse actively applied between working 30 and counter 50 electrodes. The working electrode current is preferably determined in order to quantify the amount of charges exchanged.
[0044]The term “composition releasing sequence” as used herein has a first voltametric pulse 70, followed by a rest period 80 during which no current is able to flow through the working electrode (or corresponding to a zero current phase through the working electrode 30), followed by a second voltametric pulse 90 of opposite polarity, followed by a intermediate period 160 during which no current is able to flow through the working electrode (or corre...
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According to a first aspect, the invention relates to a device (10) for electrochemically releasing a composition and comprising: one working electrode (30) comprising an electroactive conjugated polymer (40) containing or doped with said composition, a counter electrode (50), and a reference electrode (60). The device (10) is characterized in that it comprises electrical means (95, 100; 320; 165, 180) connected to the working electrode (30) and to the counter electrode (50) for obtaining at said working electrode (30) at least one composition releasing sequence (65) with respect to said reference electrode (60), each composition releasing sequence (65) comprising: a first voltametric pulse (70), followed by a rest period (80) during which no current is able to flow through said working electrode (30), followed by a second voltametric pulse (90), followed by an intermediate period (160) during which no current is able to flow through said working electrode (30).
Description
FIELD OF THE INVENTION[0001]According to a first aspect, the invention relates to a device for a controlled electrochemical release of a composition. Preferably, this device is implantable. According to a second aspect, the invention relates to a method for a controlled electrochemical release of a composition.DESCRIPTION OF PRIOR ART[0002]The active control of the release of a composition, in terms of time, quantity and accuracy of delivery, remains a big challenge. For example in the case of medical applications, the strategy of substance local delivery is really promising in comparison with systemic drug taking. Therefore, controlled release of a composition or drug has become an important mode of treatment for various diseases. A release rate of such methods can be controlled mechanically for example, as it is the case in the U.S. Pat. No. 6,748,954. Alternatively, electrochemical methods can be used as explained for instance in the patents U.S. Pat. No. 5,422,246, U.S. Pat. No....
Claims
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Login to View More IPC IPC(8): A61N1/30
CPCA61N1/306A61N1/05A61N1/04A61N1/32
InventorDELBEKE, JEANDEMOUSTIER-CHAMPAGNE, SOPHIECALLEGARI, VINCENTLEPRINCE, LUCASGERARD, BENOIT
OwnerSORIN CRM