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Correction and optimization of wave reflection in blood vessels

a wave reflection and correction technology, applied in the field of wave optimization technology, can solve the problem that the inventor is not aware of any attempt to utilize reflective waves to lessen the workload on the patient's heart, and achieve the effect of reducing the hemodynamic load on the heart of a mammal

Inactive Publication Date: 2016-01-21
CALIFORNIA INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The device reduces the workload on the heart by creating constructive interactions between existing wave dynamics and reflective waves, increasing net forward flow and lowering vascular impedance, thereby improving cardiac output and reducing the risk of heart failure.

Problems solved by technology

While it is known in the art to use a ventricular assistance device (VAD) which includes an artificial pump to treat patients suffering from congestive heart failures, the inventors are not aware of any attempt at utilizing reflective waves to lessen the workload on the patient's heart.

Method used

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  • Correction and optimization of wave reflection in blood vessels
  • Correction and optimization of wave reflection in blood vessels
  • Correction and optimization of wave reflection in blood vessels

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[0042]Aortic wave dynamics depend on heart rate, aortic compliance / wall rigidity, and the locations of reflection sites (Supra, I. Avrahami et al. (2008); and A. Hickerson et al. (2005) Experiments in Fluids 38: 534-540). The inventors have demonstrated, in “Aortic Wave Dynamics and Its Influence on Left Ventricular Workload” (2011, in press at PLos), that aortic waves have an optimum condition at which the left ventricular (LV) workload is minimized. FIGS. 5A and 5B show that at any given aortic rigidity, there exists an optimum heart rate (HR) that minimizes the LV power requirement for a set amount of cardiac output. For example, for aortic rigidity value E1, the optimum HR is around 100. At that HR, the LV pulsatile power reaches a minimum value of around 50 mWatt in an three-dimensional axisymmetric aorta model based on physiological data from C. Caro et al. (1978, Oxford University Press) “The Mechanics of the Circulation.” Since the total LV power consists of the pulsatile po...

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Abstract

The present invention provides methods and modalities that can modify wave reflection in the vascular system in order to create constructive interactions between existing wave dynamics and new reflective waves for the purpose of lowering the workload on the heart and increasing cardiac output, providing a viable option for the prevention and treatment of many heart conditions and diseases.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of U.S. patent application Ser. No. 13 / 185,377, filed Jul. 18, 2011, which claims priority to U.S. Provisional Patent Appl. No. 61 / 364,981, filed Jul. 16, 2010, both of which applications are incorporated herein in their entirety for all purposes.FIELD OF THE INVENTION[0002]The invention relates generally to methods and devices that can treat symptoms and conditions in the vascular system as well as the field of wave optimization technology.BACKGROUND[0003]Congestive heart failure (CHF) has reached an epidemic proportion in the U.S. and worldwide with serious consequences in terms of human suffering and economic impact. In the U.S. alone, there are 60,000 patients dying each year with CHF as the underlying cause. Approximately 5,800,000 Americans have been diagnosed with this condition and this number is increasing every year. In the absence of myocardial infarction, hypertension is a primary risk factor o...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M60/161A61M60/289A61M60/484A61M60/486A61M60/515A61M60/523A61M60/531A61M60/538A61M60/562A61M60/585A61M60/861
CPCA61M1/122A61B5/02A61B2017/00022A61B2090/064A61M2205/0283A61B17/12013A61N1/3629A61M60/148A61M60/484A61M60/289A61M60/531A61M60/585A61M60/486A61M60/161A61M60/523A61M60/538A61M60/515A61M60/861
Inventor GHARIB, MORTEZAPAHLEVAN, NIEMA
Owner CALIFORNIA INST OF TECH