GDF-15 and/or Troponin T for Predicting Kidney Failure in Heart Surgery Patients

a technology of troponin t and gdf-15, which is applied in the field of laboratory diagnostics, can solve problems such as significant risk of complications and coronary bypass

Inactive Publication Date: 2016-04-21
ROCHE DIAGNOSTICS OPERATIONS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Coronary bypass surgery, however, is associated with a significant risk of complications.
Consequently, the technical problem underlying the present disclosure could be seen as the provision of means and methods for identifying individuals that have an elevated risk of acute kidney injury after a surgical procedure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Patients, Materials and Methods

[0089]A total of 126 patients undergoing coronary artery bypass graft (CABG) surgery were included in the study. There were 68 males and 58 females in the study group, which ranged in age from 52 to 81 years and had a median age of 68 years. Serum creatinine levels were normal in all patients. All patients were found to have two or more vessel disease as indicated by at least one stenosis exceeding 50% of the lumen. Patients were followed for 30 days with respect to mortality and development of acute kidney injury. Endpoints of the study were: acute kidney injury (AKI; creatinine increase at least 0.3 mg / dl within 3 days after surgery), new requirement for hemodialysis, or mortality (within 30 days after surgery). Blood was taken before surgery and immediately thereafter as well as at 1, 2, and 3 days after surgery. Samples were centrifuged for 30 minutes and stored at −20° C. until analyzed.

[0090]GDF-15, troponin T, and NT-proBNP were determined with ...

example 2

Individual Patient Cases

[0095]Case 1: a 62-year-old male, suffering from 3-vessel disease with multiple stenoses, underwent CABG. He had long-standing arterial hypertension, no diabetes mellitus or smoking history. His lipids were in the normal range. However, this patient had a history of obesity. The following results were obtained for this patient before and after surgery:

beforeafter1 day after2 days after3 days aftersurgerysurgerysurgerysurgerysurgeryCreatinine0.800.720.900.810.84[mg / dl]GDF-1517001800560029001900[pg / ml]TnT12.9316.0582.0416.0352.0[pg / ml]NT-proBNP380410142015301380[pg / ml]

[0096]The patient recovered from CABG without further complications, with no occurrence of AKI. Before surgery, the amounts of GDF-15 and NT-proBNP were below the reference amount that would indicate an increased risk of AKI post surgery (1717 pg / ml and 1119 pg / ml, respectively). In addition, the amount of troponin T indicated that an increased risk of AKI could be ruled out (TnT below 13.3 pg / ml)...

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Abstract

The present disclosure relates to the field of laboratory diagnostics. Specifically, means and methods are disclosed for determining a patient's risk of suffering from acute kidney injury after a surgical procedure based on the detection of GDF-15, troponin T and / or a natriuretic peptide.

Description

PRIORITY CLAIM[0001]This application is a continuation of U.S. application Ser. No. 13 / 525,330, filed Jun. 17, 2012, which is a continuation of International Application No. PCT / EP2010 / 070058, filed Dec. 17, 2010, which claims the benefit of European Patent Application No. 09179925.4, filed Dec. 18, 2009, the disclosures of each of which are explicitly incorporated by reference in their entirety.FIELD OF THE DISCLOSURE[0002]The present disclosure relates to the field of laboratory diagnostics.BACKGROUND OF THE DISCLOSURE[0003]GDF-15 is a member of the TGF beta family; it is synthesized as a 40 kD propeptide and undergoes cleavage of its N-terminal moiety to generate an active 30 kD disulfide-linked dimeric protein that is secreted. GDF-15 has been linked to heart failure and to cardiac reperfusion injury (Kempf et al., 2006, Cir. Res. 98(3): 351-60). GDF-15 has been shown to be induced in many tissues in response to various stresses.[0004]Troponin T is a part of the contractile appa...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/74G01N33/68
CPCG01N33/74G01N33/6893G01N2333/495G01N2800/347G01N2800/50G01N2800/52G01N2333/4712G01N33/6863G01N2333/52C07K14/4716
Inventor HORSCH, ANDREAZDUNEK, DIETMARHESS, GEORGE
Owner ROCHE DIAGNOSTICS OPERATIONS INC
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