Digital control of on-chip magnetic particle assay
a technology of magnetic particle and digital control, applied in the field of assay system, can solve the problems of inability to meet the cost structure necessary to compete in the current marketplace, the inability to readily integrate the volumetric detection of magnetic particles in a stand-alone device, and the inability of most ic-based immuno-assay implementations to date to operate stand-alone, etc., to facilitate early stage detection of diseases, facilitate use, and be inexpensive to produce and distribute.
Inactive Publication Date: 2016-05-19
IN DIAGNOSTICS INC
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Benefits of technology
The patent describes a way to use a porous material, like a membrane filter, to separate plasma from whole blood cells without needing to use complicated equipment or processes. The membrane filters are compact and inexpensive, which reduces costs and allows for standalone operation. They can also be used with magnetic particles to create a platform for rapid, accurate detection. Combining this technology with a small integrated circuit (IC) makes the detection process more cost-effective and user-friendly. The entire system, including the battery and display, can be made smaller than a thumb-drive.
Problems solved by technology
However, volumetric detection of magnetic particles cannot be readily integrated in a stand-alone device, so these implementations require an external device to measure the volume magnetization in the strip.
However, most IC-based immuno-assay implementations reported to date cannot operate stand-alone since they require either off-chip components for particle detection, or micro-fluidic actuation for particle manipulation and sample preparation.
Other implementations simply cannot reach the cost structures necessary to compete in the current marketplace.
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[0043]Biosensors that use non-magnetic or magnetic particle labeling to perform assays are disclosed. A particle can serve as an aid, or label, in detecting the presence or absence of a target analyte if the particle is attached to a chemical entity that reacts with the analyte, or analyte analogue, or analyte by-product. The reaction can be immunological, nucleic acid based, covalent, ionic, hydrogen bonding, van der Waals and other chemical reaction phenomena capable of promoting or inhibiting the labeled particle from binding to a surface.
[0044]Particles may be any spherical or arbitrarily shaped localized objects, from several nanometers to tens of microns in diameter, that modulate incoming light (e.g., reflect the light, refract the light, block or absorb the light, increase or decrease the intensity of the light, change the wavelength or spectral composition of the light). Particles may also be magnetic. Magnetic particles display diamagnetic, ferromagnetic, ferrimagnetic, pa...
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Abstract
An assay system and method for use in the field of chemical testing is disclosed. The assay system can be used for filtering whole blood for testing on an integrated circuit containing digital control functionality.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation of PCT International Application No. PCT / US2014 / 033607, filed Apr. 10, 2014, which claims priority to U.S. Provisional Application No. 61 / 825,464, filed May 20, 2013; and U.S. Provisional Application No. 61 / 891,319, filed Oct. 15, 2013, each of which are incorporated herein by reference in their entireties.BACKGROUND[0002]1. Technical Field[0003]An assay system and method for use in the field of chemical testing is disclosed. More particularly, the assay system can be used for filtering whole blood for testing on an integrated circuit containing digital control functionality.[0004]2. Summary of the Related Art[0005]Point-of-Care (POC) diagnostic medical devices facilitate early stage detection of diseases, enable more individually tailored therapies, and allow doctors to follow up with patients more easily to see if prescribed treatments are working. To ensure widespread adoption, these tools must...
Claims
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IPC IPC(8): G01N21/25B01L3/00G01N33/543
CPCG01N21/255G01N33/54326B01L3/561B01L2400/0406G01N2201/068B01L2300/0636B01L2200/0605G01N2201/061B01L2300/0838B01L3/502761B01L2200/0668B01L2200/148B01L2200/16B01L2300/0874B01L2400/043G01N21/82G01N27/745G16H50/20Y02A90/10B01L2300/023B01L2300/027B01L2300/12C12Q1/686G06F21/602G06K19/06028G06K19/06037
Inventor FLORESCU, OCTAVIANWONG, DANIELMARTIN, TRACIEYAMASAKI, DUANECROMER, REMY
Owner IN DIAGNOSTICS INC