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Compositions and methods for treatment of bone defects

a technology for bone defects and compositions, applied in the field of bone defects, can solve the problems restrict or even block the formation of new bone, osteoconductive scaffolds, etc., and achieve the effects of delayed or absent resorption, stable osteoconductive scaffolds, and adequate mechanical stability

Pending Publication Date: 2018-10-11
HETTWER HLDG APS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention consists of a kit-of-parts for bone reconstruction. It includes a composition made up of a carrier and a bioactive agent, and a matrix made of solid particles and / or scaffolds. The solid particles and / or scaffolds provide support and strength to the composition.

Problems solved by technology

Drawbacks of conventional bone graft substitutes include delayed or absent resorption, which may restrict or even block bone ingrowth and formation of new bone.
In addition, some bone graft substitutes are associated with unpredictable in situ maintenance of their solid structure, which has led to treatment cases where adequate mechanical stability of the bone reconstruction construct was not sufficiently maintained and a stable osteoconductive scaffold was not achieved.

Method used

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  • Compositions and methods for treatment of bone defects
  • Compositions and methods for treatment of bone defects
  • Compositions and methods for treatment of bone defects

Examples

Experimental program
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Effect test

example 1

Reconstruction of Metastatic Bone Defects with a Bisphosphonate Eluting Bone Graft Substitute

[0267]Six patients (5 f, 1 m, mean age 64 (range 37-81) who had undergone reconstruction of metastatic bone defects with implantation of a gentamycin eluting sulfate-apatite bone graft substitute (Cerament™|G, BONESUPPORT, Lund, Sweden) which was additionally loaded with zoledronic acid, were prospectively followed for a mean of 12 months (range 6-17). In all 5 female patients, the indication for treatment was a partially contained bone defect associated with incipient or actual pathologic fracture of the acetabulum (n=3) or proximal humerus (n=2) secondary to metastatic breast cancer. The only male patient had wide resection of a solitary lung cancer metastasis from the proximal femur.

[0268]Sequential imaging (X-ray / CT) demonstrated progressive consolidation of the inserted graft material without any evidence of persistent osteolysis or local recurrence. Rapid and homogeneous remodeling typ...

example 2

Early Clinical Experience with Local Bisphosphonate Delivery for Bone Defect Reconstruction in Aggressive Benign Bone Tumors

[0269]11 patients (9 f, 2 m, mean age 35 (range 18-62)) with aggressively behaving benign bone tumors (5 GCT, 4 ABC, 2 UBC) who underwent tumor resection with curettage, high speed burring and subsequent bone defect reconstruction utilizing a combination of a biocompatible carrier, e.g. gentamycin eluting bone graft substitute (Cerament™|G, BONESUPPORT, Lund, Sweden) and a biocompatible matrix, e.g. cancellous allograft, with serial imaging (X-ray / CT) were prospectively followed for a mean of 12 months (range 6-24).

[0270]Radiographic evidence of local bone formation and remodeling by far exceeded rates and amounts usually observed with either single component alone. Rapid and homogeneous remodeling typically started in areas with cancellous bone contact in the periphery of the defects but was not limited to the cavities only. Substantial periosteal bone formati...

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Abstract

The present invention relates to the field of treatment of bone defects. The invention provides a composition for treatment of bone defects as well as methods for treatment of such defects.

Description

FIELD OF INVENTION[0001]The present invention relates to the field of treatment of bone defects. The invention provides a composition for treatment of bone defects as well as methods for treatment of such defects.BACKGROUND OF INVENTION[0002]Bone defects represent a common orthopaedic problem and can be a significant challenge to treat. They can arise as a consequence of disturbances or failure of formation and / or differentiation (bone aplasias and dysplasias), trauma, destruction due to a pathological process (infection, inflammation, tumors and implant wear associated osteolysis) or a surgical intervention or any combination of these.[0003]The three principal factors beneficial for the treatment of any bone defect regardless of its etiology, namely osteoconductive, osteoinductive and osteogenetic properties have been known for decades. In 2007, Giannudis et al added to these another vitally important factor, mechanical stability, coining the “diamond concept” of bone defect recons...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/12A61L27/02A61L27/54
CPCA61L27/365A61L27/12A61L27/025A61L27/3608A61L27/54A61L2300/406A61L2430/02A61L2300/404
Inventor HETTWER, WERNER HERBERT
Owner HETTWER HLDG APS
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