Bioresponsive Particles

a technology of bioresponsive particles and bioactive particles, applied in the field of bioresponsive particles, can solve the problems of limiting the ability of the particles to reach the cellular microenvironment in sufficient quantities to adequately fight cancer, and the treatment is completely ineffectiv

Inactive Publication Date: 2019-12-05
BOARD OF RGT THE UNIV OF TEXAS SYST
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0030]the person is, has been or will be administered a prodrug, and the enzyme is

Problems solved by technology

These immune responses either render the treatment completely ineffective, particularly when children relapse, or worse, immediately threaten the life of the child, or both.
The second approach has particle size and enzyme loading limitations.
This relatively large size forces them to stay in blood speeding their removal by the liver and spleen, and limiting their ability to reach the cellular microenvironment in suf

Method used

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Embodiment Construction

[0036]We disclose a novel hybrid approach to shielding enzymes. We first modify the enzyme surface with silica precursors and then proceed to deposit silica to a desired thickness while retaining its biological activity. An advantage of this approach is that we can control final nanoparticle size and desired enzyme activity per particle by incorporating one or more or different enzyme molecules to optimize delivery and efficacy. Unlike passive trapping of enzymes in hollow silica spheres that utilize templates ≥100 nanometers, our nanoparticles can be made as small as 20-50 nanometer to achieve optimal delivery and enzyme activity. In an embodiment we exemplify the method with catalase as a model enzyme because it can be used to detect tissues in oxidative stress using ultrasound imaging, can be used as an anti-oxidant, and its activity is easily measured using commercial assay kits. In another embodiment example, we used our method to encapsulate catalase and also to encapsulate as...

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Abstract

Shielding enzymes are made by modifying the enzyme surface with silica precursors and then depositing silica to a desired thickness while retaining biological activity of the enzyme.

Description

[0001]Priority: This application claims priority to Ser No. 62 / 679,762, filed: Jun. 01, 2018.[0002]This invention was made with government support under Grant Number UL1TR001105 awarded by the National Institutes of Health (NIH). The government has certain rights in the invention.INTRODUCTION[0003]Acute lymphoblastic leukemia (ALL) is the most common childhood cancer accounting for more than 25 percent of all pediatric cancers in the U.S. Unfortunately, 30 percent of children have immune responses to one of the most effective treatments for ALL that is highly allergenic. These immune responses either render the treatment completely ineffective, particularly when children relapse, or worse, immediately threaten the life of the child, or both. Because this treatment is essential for permanently curing children of ALL, it is critical that novel strategies be devised to completely eliminate these immune reactions.[0004]In an aspect, our invention provides for incorporating this treatmen...

Claims

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Application Information

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IPC IPC(8): A61K38/44C12N11/14A61K49/22A61K38/50A61K38/51A61K38/48
CPCB82Y5/00C12Y305/01001A61K49/223C12N11/14A61K49/225C12Y304/17011A61K38/51C12Y111/01006A61K38/4813C12Y115/01001C12Y113/12005A61K38/50C12Y404/01011A61K38/446A61K38/44C12N9/0065C12N9/96A61K49/221C07K1/1077A61K49/222A61K51/088A61K51/1244
Inventor LUX, JACQUESMATTREY, ROBERT F.YANG, ANNIE
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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