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Systems and Methods for Magnetic Resonance Phantoms

a magnetic resonance and phantom technology, applied in the field of magnetic resonance phantom systems and methods, can solve the problems of increasing variability and often struggling medical imaging, and achieve the effect of improving the operation, quality, and/or consistency of performing a magnetic resonan

Active Publication Date: 2021-11-25
WISCONSIN ALUMNI RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides phantom systems and methods for improving magnetic resonance studies, including elastography sequences and diffusion weighted imaging. The phantom includes a sealed compartment containing a hydrogel made of a crosslinked acrylamide-based polymer and a solvent. The crosslinked acrylamide-based polymer is made up of at least 50% polymerized acrylamide monomer and less than 10% crosslinking agent. The technical effects are improved consistency and quality, leading to better outcomes in magnetic resonance imaging studies.

Problems solved by technology

However, medical imaging often struggles when looking to assess information across patients, or even longitudinally for a given patient.
Furthermore, increasing the complexity of the study, such as to include additional hardware systems that are coordinated with the MM system, such as is the case in magnetic resonance elastography (MRE), can further increase the variability caused by differences in systems, manufacturers, or even the technicians or clinicians involved in the studies.

Method used

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  • Systems and Methods for Magnetic Resonance Phantoms
  • Systems and Methods for Magnetic Resonance Phantoms
  • Systems and Methods for Magnetic Resonance Phantoms

Examples

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examples

[0054]The following examples are presented by way of illustration and are not meant to be limiting in any way.

[0055]MRE Phantom:

[0056]An MRE phantom with 5 compartments of varied mechanical stiffness was fabricated with polyacrylamide hydrogel. The hydrogel material base solution was created by dissolving two polymer components—acrylamide and bis-acrylamide (Fisher Scientific, Hampton, N.H., USA)—into de-ionized water. The stiffness of the hydrogel samples was varied by changing the percentage of polymer components dissolved in the water base. Gel percentages of each sample included in the phantom were 4%, 6%, 8%, and 10%. Cross-linking of the gel was initiated by the addition of Tetramethylethylenediamine (TEMED) and ammonium persulfate (Fisher Scientific, Hampton, N.H., USA).

[0057]Four hydrogel compartments were created by filling custom 3D-printed cylindrical molds with hydrogel of different stiffness properties. Portions of each sample material, along with additional samples of ...

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Abstract

Embodiments of the disclosure provide a magnetic resonance (MR) phantom including a housing, a base medium disposed within the housing, and one or more compartment extending through the base medium, the one or more compartment comprising a crosslinked acrylamide-based polymer. The MR phantoms may be used as calibration phantoms for magnetic resonance elastography sequences and diffusion weighted images.

Description

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH[0001]This invention was made with government support under DK117354 and EB025729 awarded by the National Institutes of Health. The government has certain rights in the invention.BACKGROUND[0002]Medical imaging is a fundamental resource in the modern practice of clinical medicine. The ability to acquire anatomical, physiological, and pathological information about the patient non-invasively makes medical imaging ubiquitous in many clinical applications. Furthermore, medical imaging can be used to direct and deliver therapeutic or surgical procedures.[0003]In all of these settings, medical imaging provides powerful resources for the practice of clinical medicine by providing the ability to secure patient-specific information. However, medical imaging often struggles when looking to assess information across patients, or even longitudinally for a given patient. This occurs because medical imaging systems reflect a great deal of variabili...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01R33/58G01R33/30
CPCG01R33/58A61B5/055G01R33/30G01R33/56341G01R33/56358A61B5/4244
Inventor ROLDÁN-ALZATE, ALEJANDRORUTKOWSKI, DAVIDARRIBAS, DIEGO HERNANDO
Owner WISCONSIN ALUMNI RES FOUND