Laser Optoacoustic Ultrasonic Imaging System (LOUIS) and Methods of Use

Abstract

Provided herein are the systems, methods, components for a three-dimensional tomography system. The system is a dual-modality imaging system that incorporates a laser ultrasonic system and a laser optoacoustic system. The dual-modality imaging system generates tomographic images of a volume of interest in a subject body based on speed of sound, ultrasound attenuation and / or ultrasound backscattering and for generating optoacoustic tomographic images of distribution of the optical absorption coefficient in the subject body based on absorbed optical energy density or various quantitative parameters derivable therefrom. Also provided is a method for increasing contrast, resolution and accuracy of quantitative information obtained within a subject utilizing the dual-modality imaging system. The method comprises producing an image of an outline boundary of a volume of interest and generating spatially or temporally coregistered images based on speed of sound and / or ultrasonic attenuation and on absorbed optical energy within the outlined volume.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This is a continuation under 35 U.S.C. § 120 of pending non-provisional application U.S. Ser. No. 13 / 748,498, filed Jan. 23, 2013, which claims benefit of priority under 35 U.S.C. § 119(e) of provisional application U.S. Ser. No. 61 / 605,276, filed Mar. 1, 2012, now abandoned and of provisional application U.S. Ser. No. 61 / 632,387, filed Jan. 23, 2012, now abandoned, all of which are hereby incorporated by reference.BACKGROUND OF THE INVENTIONField of the Invention[0002]The present invention relates to the field of biomedical imaging and discloses the designs and methods used for a tomographic system that can provide comprehensive medical information about a portion of the body under examination. More specifically, the present invention provides a Laser Optoacoustic Ultrasonic Imaging System (LOUIS) for three-dimensional tomography of a subject or portion or body part thereof.Description of the Related Art[0003]Imaging internal structures ...

AI Technical Summary

Benefits of technology

The present invention provides a method for improving the accuracy and resolution of quantitative information obtained from a subject using a laser ultrasound or laser optoacoustic imaging system. The method involves producing an image of the outline boundary of a volume of interest within the subject using the laser ultrasound or laser optoacoustic imaging system, and then using an algorithm to generate a spatially or temporally coregistered optoacoustic image based on absorbed optical energy and the speed of sound or ultrasonic attenuation within the outlined volume boundary. This improves the contrast and resolution of the obtained information.

Problems solved by technology

However, the prior art lacks a system that can provide comprehensive information about tissues, including anatomical structure (morphology) and molecular composition simultaneously with information about tissue normal or abnormal function.

However, these systems are not three-dimensional tomography systems and their design cannot be used for biomedical imaging.

However, the prior art lacks description of a design for 3D laser ultrasound tomography system capable of volumetric visualization of biomedical objects through algorithms of reconstruction tomography, such as filtered back-projection tomography and of the full set of properties of the layers of the materials for the most effective generation of ultrawide-band ultrasound with laser pulses.

However, the prior art lacks description of a 3D tomography system that combines laser ultrasonic and laser optoacoustic tomography in one imaging module, allows natural coregistration of volumetric images acquired and reconstructed using the two modalities and thereby provides the most comprehensive anatomical, functional and molecular information for the physician or biomedical researcher.

However, the proposed design was limited to a scanning system based on a single transducer that is focused into a point at some specific depth (19).

This design could only be used for one-dimensional depth profiling, potentially for two-dimensional imaging, even though the design is shown only for a single transducer, but not for three-dimensional tomography.

This design remains just an idea several years after the original publication likely because authors themselves realized a number of technical deficiencies limiting usefulness of this system in biomedical applications.

A major drawback of this design is that the array is focused into a line and it will take a long time to acquire complete 2D image of a slice, which is not practical.

Moreover, the main problem in the design is that it cannot be used for optoacoustic imaging as described because the laser pulse strikes a strongly absorbing polymer layer and there is no laser pulse delivery directly to the tissue surface.

Detection and treatment of breast cancer especially is lacking the needed technologies.

The current problems of breast cancer care are numerous (1-5), i.e., a large number (˜20%) of breast tumors are missed by x-ray mammography, especially in the dense breast of younger women, (2) about 75% of biopsies are unnecessary, cancers are missed due to insufficient contrast of ultrasound guided biopsy, and a lack of fast and safe functional imaging techniques to assess the effectiveness of anticancer chemotherapy and other therapies.

While prior art systems may provide a base for the design and development of a clinically viable laser optoacoustic ultrasonic imaging system (LOUIS) (19,20), Previously developed optoacoustic imaging systems and laser ultrasound monitoring systems have limited resolution and sensitivity, have limited field of view, have reduced accuracy of quantitative information, have artifacts associated with projection onto image plane of objects located out of the image plane, and have no capability to provide detailed information on distribution of speed of sound.

Particularly, the prior art is deficient in a tomographic system that combines laser ultrasound and laser optoacoustic tomography useful for many biomedical applications such as, but not limited to, cancer detection or screening, monitoring of anticancer therapies, detection and characterization of vascular diseases, monitoring drug distribution, distribution of nanoparticles or contrast agents and physiological and pathological processes.

Images