Derivatives of 10-methylene lipids, process for preparing such derivatives and use thereof

a technology of methylene lipids and derivatives, which is applied in the preparation of carboxylic compounds, biocide, organic chemistry, etc., can solve the problems of low production yield related to total lipid content, preventing further industrial use, and unable to achieve a wide range of purification methods suitable for industrial scale production at reasonable cos

Pending Publication Date: 2022-06-02
GINKGO BIOWORKS INC
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Problems solved by technology

Even if authors state that tuberculostearic acid is a main component of the phospholipids from Mycobacterium species, its low production yield related to total lipid content prevented further industrial use.
Although the production of 10-methylene biological precursor of tuberculostearic acid can now be envisaged at larger scale from genetically modified cells, stability of such precursor does not allow a broad range of purification methods which would be suitable for industrial scale production at reasonable cost.

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  • Derivatives of 10-methylene lipids, process for preparing such derivatives and use thereof
  • Derivatives of 10-methylene lipids, process for preparing such derivatives and use thereof
  • Derivatives of 10-methylene lipids, process for preparing such derivatives and use thereof

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[0087]The embodiments of the present invention will be better understood by looking at the different examples below, illustrated by the following figures showing preferred pathways and products preparation schemes and methods. On all the figures, R represents an alkyl group, for example chosen from a methyl, ethyl, propyl and isopropyl group.

[0088]FIG. 1 represents a pathway from 10-methylene-palmitic ester / acid to 10-bromomethyl-palmitic ester / acid and 10-aminomethyl-palmitic ester / acid (left side), and 10-methylene-stearic ester / acid to 10-bromomethyl-stearic ester / acid and 10-aminomethyl-stearic ester / acid (right side). R may represent an alkyl or hydrogen group.

[0089]FIG. 2 represents the polycondensation of 10-aminomethyl-stearic acid to a polyamide, directly with water elimination or via the formation of the corresponding 10-aminomethyl-stearic ester. In the figure, n represents the number of units of the polyamide. Also shown on bottom left is ring opening polymerization (ROP...

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Abstract

The present invention relates to derivatives of 10-methylene lipids, their preparation and their use.

Description

FIELD OF THE INVENTION[0001]The present invention relates to derivatives of 10-methylene lipids, their preparation and their use.BACKGROUND OF THE INVENTION[0002]Tuberculostearic acid (10-methylstearic acid) and corresponding 10-methylene biological precursor are known, see, e.g. Yuzuru Akamatsu and John Law, “Enzymatic synthesis of 10-methylene stearic acid and tuberculostearic acid”, Biochemical and Biophysiscal Research Communications, Vol. 33, Issue 1, 10th Oct. 1968, pages 172-176.[0003]Even if authors state that tuberculostearic acid is a main component of the phospholipids from Mycobacterium species, its low production yield related to total lipid content prevented further industrial use. Recently, Novogy, Inc. was able to insert and to express gene sequences responsible for methylation of fatty acids into Yarrowia lipolytica (Shaw et al., “Heterologous production of 10-methyl stearic acid”, WO2018 / 057607).[0004]Although the production of 10-methylene biological precursor of ...

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07C229/08C07C53/19C07C59/01C07C227/08C07C51/367C07C51/363C08G69/06C07D313/00C07D225/02A01N37/36
CPCC07C229/08C07C53/19C07C59/01C07C227/08C07C51/367A01P3/00C08G69/06C07D313/00C07D225/02A01N37/36C07C51/363C07C69/63C08L77/00C07C69/533C07C57/03C07C57/52C07C59/105
Inventor RABOIN, JEAN-CHRISTOPHESTRUB, HENRI
Owner GINKGO BIOWORKS INC
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