Amelioration of Dupuytren's disease

a dupuytren's disease and melioration technology, applied in the field of melioration of dupuytren's disease, can solve the problems of increasing the disruption of collagen, no long-term benefit, and immediate

Inactive Publication Date: 2007-12-18
ADVANCE BIOFACTURES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Additionally, case reports describing the use of allopurinol and methylhydrazine and steroids have shown some immedi

Method used

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Embodiment Construction

[0007]Collagenase is an enzyme that has the specific ability to digest collagen. It is derived commercially from fermentation by Clostridium histolyticum, and is purified by a chromatographic technique.

[0008]The potency assay of collagenase is based on the digestion of undenaturated collagen (from bovine tendon) at pH 7.2 and37 degrees C for 20-24 hours. The number of peptide bonds cleaved are measured by reaction with ninhydrin. Amino groups released by a trypsin digestion control are subtracted. One net ABC unit of collagenase will solubilize ninhydrin reactive material equivalent to 1.09 nanomoles of leucine per minute.

[0009]Sterilized lyophilized collagenase powder is available having a minimum assay of 50 ABC units per mg. The assay may range considerably above that from batch to batch, but is taken into account in determining the weight of powder to use with a pharmaceutically acceptable carrier, e.g. normal saline, in preparing a desired concentration for treatment.

[0010]The ...

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Abstract

The cords of Dupuytren's disease are injected with collagenase, the hand is immediately immobilized and maintained immobile for several hours. The cord becomes relaxed or ruptured, relieving the hand contracture of the disease.

Description

BACKGROUND[0001]Dupuytren's disease (Dupuytren's contracture) of the hand occurs mainly, though not only exclusively, in men. It is found more frequently in middle aged and elderly persons, in those of Northern European ancestry, and in those with certain chronic illnesses, e.g. diabetes, alcoholism and smoking. The cause is not known.[0002]The disease is characterized by thickening and contracture of the fascia (connective tissue) of the palm, usually progressing to flexion deformities and involvement of one or more fingers. This results from formation of longitudinal cords of indurated fibrous tissue in the palm and extending into the finger. A similar lesion sometimes occurs in the foot. No effective palliative treatment has been found; severe cases are treated by surgery (fasciotomy or fasciectomy).[0003]Currently, the most commonly performed therapy for involutional and for residual stages of Dupuytren's disease is surgical fasciectomy (i.e., removal). Several authors have prop...

Claims

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Application Information

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IPC IPC(8): A61K38/43A61K38/46A61K38/48C12N11/02
CPCA61K38/4886A61P21/00
Inventor WEGMAN, THOMAS L.
Owner ADVANCE BIOFACTURES
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