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Systems and methods for reversibly blocking nerve activity

Active Publication Date: 2015-10-06
CASE WESTERN RESERVE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a way to block nerve impulses using an implanted electrode to treat various conditions such as spasms, spinal cord injury, and pain. The method uses a specific waveform that causes the nerve membrane to become incapable of transmitting an action potential and is quickly reversible. This technique can selectively block larger nerve fibers while allowing sensory information to travel through unaffected nerve fibers. The results can be used for pain reduction and treatment of certain neurological disorders.

Problems solved by technology

Spinal cord injury can lead to uncontrolled muscle spasms.
Peripheral nerve injury can cause pain, such as neuroma pain.
Problems have been encountered, such as damage and destruction to the nerve, and the inability to achieve a differentiation of nerve blocking effects among large and small nerve fibers in a whole nerve.

Method used

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  • Systems and methods for reversibly blocking nerve activity
  • Systems and methods for reversibly blocking nerve activity
  • Systems and methods for reversibly blocking nerve activity

Examples

Experimental program
Comparison scheme
Effect test

example 1

Neuroma Pain

[0041]A system 10 such as shown in FIG. 1 can be used to block neuroma pain association with an amputated arm of leg. In this arrangement, one or more electrodes 22 are secured on, in, or near the neuroma. The pulse controller 14 can comprise a handheld, battery powered stimulator having an on-board microprocessor. The microprocessor is programed by a clinician to generate a continuous waveform that embodies features of the invention, having the desired amplitude, duration, and shape to block nerve impulses, in the region of the neuroma. The pulse controller 14 can be coupled to the electrode, e.g., by percutaneous leads, with one channel dedicated to, each electrode used. A control signal source 12 could comprise an on-off button on the stimulator, to allow the individual to suspend or continue the continuous application of the waveform, to block the neuroma pain. No other special control functions would be required.

example 2

Muscle Spasms Due to Spinal Cord Injury, Cerebral Palsy, or Tourett's Syndrome

[0042]A system 10 like that shown in FIG. 1 can be used to block muscle spasms due to, e.g., a spinal cord injury, cerebral palsy, or tourett's syndrome. In this arrangement, one or more electrodes 22 are secured on, in, or near the nerve or nerves affecting the muscle spasms. As in Example 1, the pulse controller 14 can comprise a handheld, battery powered stimulator having an on-board microprocessor. The microprocessor is programed by a clinician to generate a continuous waveform that embodies features of the invention, having the desired amplitude, duration, and shape to block nerve impulses in the region of the muscle spasms. As in Example 1, the pulse controller 14 can be coupled to the electrode, e.g., by percutaneous leads, with one channel dedicated to each electrode used. A control signal source 12 could comprise an on-off button on the stimulator, to allow the individual to suspend or continue th...

example 3

Block Uncoordinated Finger Flexure Spasms Due to Multiple Sclerosis or Stroke

[0044]A system 10 like that shown in FIG. 1 can be used to block finger flexure spasms due to, e.g., a multiple sclerosis or stroke. In this arrangement, one or more epimysial and intramuscular electrodes 22 are appropriately implanted by a surgeon in the patient's arm. The implanted electrodes 22 are positioned by the surgeon by conventional surgical techniques to block conduction of impulses to finger flexure muscles. As in Example 1, the pulse controller 14 can comprise a handheld, battery powered stimulator having an on-board microprocessor. The microprocessor is programed by a clinician to generate a continuous waveform that embodies features of the invention, having the desired amplitude, duration, and shape to provide a low level block of nerve impulses to the finger flexure muscles. A control signal source 12 could comprise an on-off button on the stimulator, to allow the individual to select the co...

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PUM

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Abstract

Systems and methods for blocking nerve impulses use an implanted electrode located on or around a nerve. A specific waveform is used that causes the nerve membrane to become incapable of transmitting an action potential. The membrane is only affected underneath the electrode, and the effect is immediately and completely reversible. The waveform has a low amplitude and can be charge balanced, with a high likelihood of being safe to the nerve for chronic conditions. It is possible to selectively block larger (motor) nerve fibers within a mixed nerve, while allowing sensory information to travel through unaffected nerve fibers.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a broadening reissue of Ser. No. 12 / 272,394, now U.S. Pat. No. 7,389,145, entitled “SYSTEMS AND METHODS FOR REVERSIBLY BLOCKING NERVE ACTIVITY,” issued on Jun. 17, 2008, by KILGORE et al. [0002]This application is a national stage filing under 35 U.S.C. 371 of International Application PCT / US02 / 04887, filed Feb. 20, 2002, which claims priority from U.S. application Ser. No. 60 / 269,832, filed Feb. 20, 2001, the specifications of each of which are incorporated by reference herein. International Application PCT / US02 / 04887 was published under PCT Article 21(2) in English.GOVERNMENT FUNDING[0003]This invention was made with government support under grant No. EB002091, awarded by the NIH-National Institute of Biomedical Imaging and Bioengineering. The government has certain rights in the invention.FIELD OF THE INVENTION[0004]This invention relates to systems and methods for selectively blocking nerve activity in animals, inc...

Claims

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Application Information

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IPC IPC(8): A61N1/34A61N1/36
CPCA61N1/36071A61N1/36164A61N1/36171A61N1/36178A61N1/3605
Inventor KILGORE, KEVIN L.GRILL, WARREN M.MCINTYRE, CAMERON C.MORTIMER, JOHN T.
Owner CASE WESTERN RESERVE UNIV
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