42 results about "Biomodulators" patented technology

Methods for producing nucleic acid fragment libraries that express highly diverse peptide domains, wherein the nucleic acid fragments are derived form microorganisms or eukaryotes with compact genomes. Also peptides derived form the libraries wherein the peptides are selected on the basis of their abilities to bind selected target proteins, including c-jun and antibodies raised against dust mite allergens.

The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step of: (i) producing a gene fragment expression library derived from defined nucleotide sequence fragments; and (ii) assaying the expression library for at least an amino acid sequence derived from step (i) for a biological activity wherein that activity is different from any activity the amino acid sequence may have in its native environment.

The present invention relates to methods based on the interactions of thrombin as a biological regulator. More specifically, the invention relates to the interactions of thrombin with regard to Notch signaling, Jagged1, PAR1, and cellular effects mediated thereby. The invention relates to the discovery that thrombin cleaves Jagged1 to produce non-membrane soluble Jagged1 (sJ1). The soluble Jagged1 protein can affect Notch signaling and, among other things, mediate the release of FGF-1 and / or IL-1α from a cell. The invention further relates to the role(s) of thrombin and signaling via Notch proteins and the effect on thrombosis, angiogenesis, and / or differentiation, among other processes. Moreover, the invention relates to discovery that thrombin, sJ1, and TRAP mediate, inter alia, rapid non-classical release of FGF-1, and proteins associated therewith (e.g., p40 Syn1 and S100A13, among others), and the effect growth and proliferation of a stem cell without loss of differentiation potential. Thus, the present invention relates to methods of clonally expanding a pluripotent stem cell while preserving the differentiation potential of the cell, a process termed “stamatogenesis.”

The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid.

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.

The present invention relates to the use of at least a non-peptidyl compound as a biological modulator of insulin activity or insulin-related activity, which compound possesses ionic and hydrophobic chemical moieties spatially located so as to mimic at least an ionic and hydrophobic amino acid residue of insulin, which amino acids are associated with the binding of insulin to its receptor.

The invention relates to a biological regulator with a function of increasing fruit setting percentages of fruit vegetables and a method for preparing the biological regulator. The biological regulator comprises, by weight, 6-10 parts of 2, 4-dichlorphenoxyacetic acid, 6-8 parts of diethylaminoethyl hexanoate DA-6, 7-10 parts of forchlorfenuron, 3-5 parts of sodium nitrophenolate, 0.5-1 part of falling preventive elements, 4-5 parts of gibberellin, 8-10 parts of benzylaminopurine, 3-5 parts of dispersing agent ethylene-vinyl acetate copolymers, 2-3 parts of emulsifiers OP-10, 4-6 parts of antifreezing agents ethylene glycol and 100-150 parts of absolute ethyl alcohol. The biological regulator and the method have the advantages that the biological regulator is wide in acting surface and canbe applied to multiple fields; photosynthesis, respiration and substance absorption and translocation of plants can be regulated and controlled, physiological procedures for signal transduction, stoma opening and closing, osmotic adjustment, transpiration and the like can be adjusted, and accordingly growth and development of the plants can be controlled; the biological regulator is low in usage,high in speed and benefit and little in residual toxicity, and only needs to be sprayed once for most fruit vegetables in each season according to set time; the biological regulator rarely can be affected by environments, the fruit setting percentages of the fruit vegetables can be increased by the biological regulator, use modes for the biological regulator are easy and convenient to operate, and the time and labor can be saved.

The invention discloses a method for increasing the seed production yield of hybrid rice 'Fengliangyou No.4'. According to the method, an improved variety 'Feng' 9311 is taken as a male parent and an improved variety 'Guangzhan' 63S is taken as a female parent, and the improved variety 'Feng' 9311 is combined with the improved variety 'Guangzhan' 63S for hybrid seed production to produce seeds of the hybrid rice 'Fengliangyou No.4'; the method specifically comprises the following steps: (1) carrying out seed breeding; (2) raising rice seedlings; (3) transplanting the rice seedlings; (4) carrying out field management including the processes of fertilizing, applying 'Tiaohuabao' (a farm chemical), preventing and controlling pest and disease damage and applying '920' (a farm chemical); (5) pollinating; and (6) harvesting. Through the measures of improving a cultivation technology, applying a bio-regulator, adjusting a flowering phase, preventing and controlling pests and diseases and the like, the acre yield of the seed production of the hybrid rice 'Fengliangyou No.4' is greatly increased and is increased to 300kg from 120kg, so that the large-area seed production popularization of the hybrid rice 'Fengliangyou No.4' is achieved; the method is suitable for popularizing the cultivation of the hybrid rice 'Fengliangyou No.4'.

Systems for multiplexed analysis of gene expression using coded RNA reporters. The coded RNA reporters are expressed from a library of reporter genes, with each reporter gene directing expression of a distinguishable coded RNA reporter. Each RNA reporter thus reports activity of a corresponding reporter gene. The distinguishable reporter RNA species allow otherwise similar reporter genes to be functionally linked to different effectors within a cell reporter library. Multiplexed analysis of reporter gene activity is carried out by measuring the level of each RNA reporter within the cell reporter library, thus providing an ability to analyze the effect of a biological modulator on many effectors.

The invention discloses a preparation method of high-hardness water-resistant modified potassium fulvic acid powder. The preparation method comprises the following steps of: with potassium fulvic acid dry powder as a main raw material, feeding the potassium fulvic acid dry powder into a sulfonating tower by a feeder through a sulfonating process, wherein the feeder, an air blower, the sulfonating tower and a bag packing machine are connected to form a production line; atomizing a sulfonating agent and feeding the atomized sulfonating agent into the sulfonating tower by the air blower; and carrying out sulfonating treatment for 2-5 seconds in the tower to prepare the high-hardness water-resistant modified potassium fulvic acid finished product, and conveying the finished product into the bag packing machine for bagging and packing, wherein the proportion of the sulfonating agent to the potassium fulvic acid dry powder is (1%-3%):100%, the sulfonating agent is sulfur trioxide, the fulvic acid content of the finished product is 46%-55%, the water solubility is 96%-98% and the condensation limit is 18-20. The finished product can be used as a leaf fertilizer, a drip fertilizer, a humic acid micro fertilizer, a plant biological regulator or a feed additive. Besides, the finished product prepared by the preparation method disclosed by the invention is high in physiological activity, good in water solubility and stability, extremely high in condensation limit, wide in application range, and easy to transport and store.

The present invention relates to methods based on the interactions of thrombin as a biological regulator. More specifically, the invention relates to the interactions of thrombin with regard to Notch signaling, Jagged1, PAR1, and cellular effects mediated thereby. The invention relates to the discovery that thrombin cleaves Jagged1 to produce non-membrane soluble Jagged1 (sJ1). The soluble Jagged1 protein can affect Notch signaling and, among other things, mediate the release of FGF-1 and / or IL-1α from a cell. The invention further relates to the role(s) of thrombin and signaling via Notch proteins and the effect on thrombosis, angiogenesis, and / or differentiation, among other processes. Moreover, the invention relates to discovery that thrombin, sJ1, and TRAP mediate, inter alia, rapid non-classical release of FGF-1, and proteins associated therewith (e.g., p40 Syn1 and S100A13, among others), and the effect growth and proliferation of a stem cell without loss of differentiation potential. Thus, the present invention relates to methods of clonally expanding a pluripotent stem cell while preserving the differentiation potential of the cell, a process termed “stamatogenesis.”

The present invention relates to a compounded chemical preparation for raising adverse resistance of vegetable, fruit tree and crops. Its formula composition includes biological regulating agent 10g, germicide (pesticide) 25-75 g, edible salt 50g, edible vinegar 100g and water 15000g. Besides, said invention also provides its application method.

The invention discloses a preparation method of a bioorganic fertilizer. The method comprises the following steps: 1, preparing a substrate: naturally solarizing or drying pig dung, carrying out ultraviolet lamp irradiation disinfection for 30-120min, and overturning the pig dung 2-3 times in the irritation process to prepare the fermentation substrate; 2, carrying out two stage fermentation: sterilizing the fermentation substrate at 121DEG C for 20-30min, cooling the sterilized substrate to room temperature, adding water, and uniformly stirring to prepare a solid fermentation medium, inoculating a lactobacillus strain liquid, carrying out anaerobic fermentation for 48h, inoculating a Candida utilis strain liquid, introducing aseptic air, and carrying out aerobic fermentation for 48-72h to obtain a fermentation product; 4, drying: drying the fermentation product at 55-60DEG C; and 5, proportioning: adding a biological regulator to the dried fermentation product according to a weight ratio of 100:(0.2-1) in order to prepare the bioorganic fertilizer, wherein the biological regulator is photosynthetic bacteria and azotobacteria. The bioorganic fertilizer prepared in the invention can greatly improve the output per 666.7m<2> of land of crops.

The invention provides a biological seed coating agent for controlling soybean phytophthora root rot, a preparing method thereof and a using method of the seed coating agent and belongs to the technical field of agricultural biotechnology. The seed coating agent comprises 20% by mass of streptomyces dorenlacusensis M1-4 inoculum, 10% by mass of a plant activator, 5% by mass of a biological conditioning agent, 10% by mass of a nutrition element solution and 10% by mass of an auxiliary agent, with the balance being water. The preparing method includes adding 1% of carboxymethylcellulose sodium and 10% of polyvinyl alcohol into water, heating to 80 DEG C, stirring for 20 min until film forming agents are fully dissolved, cooling to room temperature, adding 0.4% of rhodamine, 3% of glycerol and 0.5% of peregal O-25, and adding 20% of the actinomycete streptomyces M1-4 inoculum, 5% of the biological conditioning agent, 10% of the nutrition element solution, 10% of the plant activator and the water into the auxiliary agent according to mass percentages of components in the seed coating agent. The seed coating agent significantly inhibits soybean diseases and pests, can increase the root shoot ratio, can increase soybean stress resistance and can increase soybean quality and yields.

The invention discloses a method for increasing the seed production yield of dandelions, and belongs to the technical field of plant cultivation. The method comprises the steps of seed breeding, seedling growing land selecting, seedling growing, planting land selecting, transplanting, field management, harvesting and the like. Through the measures of improvement in a cultivating technology, an application of biological regulator, disease and pest prevention and the like, the seed production yield of dandelions is greatly increased, and is increased by about 40% compared with that of a traditional method, a dust collector is adopted for collecting dandelion seeds, cost is low, and efficiency is high.

The invention discloses a beauveria bassiana barrel mixed agent and a preparation method of the beauveria bassiana barrel mixed agent. The beauveria bassiana barrel mixed agent comprises the components in parts by weight: 10.0-20.0g of powder, 50.0ml of an assistant and 10,000-20,000ml of water; the powder comprises the components in parts by weight: 90.0-100.0g of beauveria bassiana high spore, 0-10.0g of filler, 0-2.0g of a high-temperature protective agent, 0-3.0g of a nutrition thickener, 0-0.5g of stable protective agent, 0-0.2g of antioxidant, 0-0.5g of a biological protective agent, 0-1.0g of an ultraviolet protective agent A and 0-0.5g of a biological regulating agent; the assistant comprises the components in parts by weight: 10.0g of a dispersing agent, 15.0-25.0g of an emulsification dispersing agent A, 15.0-25.0g of an emulsification dispersing agent B, 5.0g of an ultraviolet protective agent B and 30ml of water. According to the beauveria bassiana barrel mixed agent and the preparation method of the beauveria bassiana barrel mixed agent, the pesticide efficiency is guaranteed, the long shelf life and the high efficiency of the pesticide application operation can be realized, and the commercialization and industrialization of beauveria bassiana can be promoted.

The invention discloses a composite biomass pellet bacterial fertilizer. The composite biomass pellet bacterial fertilizer comprises an enzyme bacterium preparation, sludge of a monosodium glutamate plant, soybean hulls, soybean meal, potassium dihydrogen phosphate for feed, crop straws (fermented), edible bacterial sticks, wheat bran, sweet wormwood herb powder, cystine, brown algae, bentonite, humic acid, a bioregulator, phytase and an appropriate amount of stone dust and water. Through the way, the composite biomass pellet bacterial fertilizer disclosed by the invention is produced by taking the sludge of the monosodium glutamate plant as a culture medium and utilizing wastes. The product has the advantages of low production cost, convenience in manufacturing, a comprehensive effect, high efficiency and balance, as well as nutrition of an organic fertilizer and functions of the composite bacterial fertilizer, thereby having certain economic significance and social significance.

The invention discloses a fig planting rooting promoting fertilizer and a preparation method therefor. The fertilizer is prepared from the following raw materials: ochre powder, silkworm chrysalis powder, brewer's grains, diatomite, industrial starch, saturated lime water, an urease inhibitor, ammonium dihydrogen phosphate, urea, a growth regulator, a microbial agent, a flocculant and a proper amount of water. By virtue of liquid fermentation and use of the flocculant, a relatively pure fermented product is obtained, so that the biological regulator can be effectively protected; the urease inhibitor can be used for effectively promoting absorption of nitrogen by plants while nitrogen can be used for promoting growth of plant blades and synthesis of chlorophyll; phosphorus can be further used for promoting formation and growth of crop root systems in an early stage, so that the ability of crops for being adaptive to external environmental conditions is improved.

The invention discloses a soilless cultivation substrate for red ginger flower cultivation, which is composed of the following raw materials in parts by weight: 8-10 parts of Artemisia annua, 3-5 parts of honeysuckle, 4-6 parts of dandelion, 30-35 parts of bagasse, 5-8 parts of okara, 5-8 parts of urea, 1-3 parts of jasmonic acid, 1-3 parts of salicylic acid, 0.5-1 part of xanthan gum, 3-5 parts of orange peel and 50 parts of rice washing water. The preparation method of the red ginger flower cultivation substrate of the present invention mainly includes the steps of pulverizing traditional Chinese medicine, preparing nutrient solution, fermenting and mixing. According to the growth characteristics of the red ginger flower, the present invention enhances the effects of repelling and killing insects by adding Artemisia annua, honeysuckle and dandelion; adopts orange peel and various biological regulators to configure the nutrient solution, enriches the growth conditions of the red ginger flower. The required nutrients can promote plant growth; by adding bagasse and urea, the nutritional needs of red ginger flowers are met, the permeability and permeability of the substrate are enhanced, and the cultivation effect is good.

The invention relates to the technical field of agricultural planting, in particular to a biological regulator for soil improvement and a preparation method thereof. The regulator is prepared from lime, bentonite, polyvinyl akohol, polyacrylic acid, plant straw, animal dung, potassium fulvic acid, stellera chamaejasme, a flaccid knotweed herb, calamus, green bristlegrass herb, tobacco, mugwort and strains. A preparation method comprises the steps that the plant straw, the stellera chamaejasme, the flaccid knotweed herb, the calamus, the green bristlegrass herb, the tobacco and mugwort are weighed and smashed, the mixture is put in a fermenting tank, the animal waste, the plant ash, the potassium fulvic acid and the lime are added, and then the fermenting strains and water are added for natural fermentation; after fermentation is completed, the bentonite, the polyvinyl akohol and the polyacrylic acid are added, and even mixing is performed to obtain the regulator. The regulator can effectively regulate a soil nutrition structure, can also effectively kill injurious insects in soil and provides guarantee for healthy growth of stevia rebaudiana, and the preparation method of the regulator is simple and convenient to operate and has a good application value.

A set of small molecules ERα biomodulators that kill therapy-resistant ERα positive breast, ovarian, and endometrial cancer cells. These small molecules have increased therapeutic potential because of an increased ability to kill therapy-resistant breast cancer cells compared to BHPI and other conventional therapies (endocrine therapies, tamoxifen and fulvestrant / ICI). The new compounds do not only inhibit proliferation of the cancer cells but actually kills them, which prevents reactivation of tumors years later.

Bio-regulators from a group of quaternary ammonium moieties modify a gene expression in undesirable plants to inhibit growth and robustness and enhance the effectiveness of herbicides. Such bio-regulator may be applied to plants through seed treatments, root drenching, spraying and dusting, or to soil were desirable crops are planted or will be planted. Bio-regulators may be duel-acting; causing beneficial modification to gene expressions in desirable plants while modifying gene expression in undesirable plants, making them more susceptible to herbicides. Bio-regulators are Ester Compounds, BMIA Compounds or related salts of those compounds.

A wearable device for the quantification of regulatory substances produced in the body, such as analytes and hormones, is disclosed. The wearable device includes contact sensors formed on an outer portion of a casing of the wearable device, and those contact sensors are positioned to contact skin of a wearer of the device and configured to measure galvanic skin response and temperature. The wearable device also includes a microprocessor in the casing of the wearable device adapted to control programs and execute algorithms, a system memory in the casing of the wearable device adapted to store data, an entry port in the casing of the wearable device adapted to receive a biological-assay cartridge containing a biological sample, and a biological-assay reader placed inside the casing of the device and configured to read the biological sample.

The invention provides a diatomite calcinations agricultural infiltration disk which is used in conjunction with feed water piping in agricultural irrigation, wherein, 50-100 portions of diatomite, 50-100 portions of diatomite filter aid, 5-15 portions of organic bond, 5-15 portions of inorganic bond, 50-150 portions of water are taken as raw materials and then are made into porous composite material for agricultural irrigation after the process of mixing, molding, drying and calcining. The apertures in the calcined diatomite infiltration irrigation disk with a hollow structure which can be provided with one or more supporting points are between 0.1-1.0 micron and the range of the porosity thereof is 50-90 percent. The invention can perfectly solve the problems of uneven discharge flow of infiltration irrigation device and the blockage of seeping holes, thereby realizing the integrated and associated operation of irrigation and fertilization, irrigation and application as well as irrigation and bio-regulator. The invention has low technical cost, simple manufacturing technique, and long service life and can play an important role in agricultural irrigation.

The invention provides a method for the advanced treatment and recycling of petroleum and petrochemical wastewater and relates to the technical field of water treatment, in particular to the technical field of the advanced treatment and recycling of oil refining wastewater and oilfield produced wastewater. With an agitator adopted, anaerobic biological reaction, aerobic treatment are carried out on the petroleum and petrochemical wastewater in sequence, finally the wastewater with mud going through the aerobic treatment is filtered by an ultrafiltration membrane, the filtered water is recycle water. The method of the invention can shorten cultivation cycle at the initial stage of wastewater biochemistry, improve impact resistance capacity of the biochemical system in the process of operation, and adapt to wastewater which is biochemically difficult to degrade and suffers lack of nutrients; in addition, the method can strengthen activity of microorganism by biological modifier, sustain species group stability of micro-ecological flora and ensure long term, valid and stable operation of the whole system; and the treated recycle water features little change of water quality and low retention level of organism.

The invention discloses a compound microorganism selenium-rich fertilizer special for rice. The fertilizer is prepared from urea, monoammonium phosphate, ammonium sulfate, potassium sulfate, bentonite, strains, nano-powder, rooting powder, fertilizer efficiency increasing essence, an SAD-resistance inducer 1, a cell growing agent, multiplex trace elements, a biological regulator, medical stone powder, selenium powder, a biological water retaining agent, chlorine sodium nitrate, sodium naphthalene-1-acetate, ammonium molybdate, DA-6, KT-30, a water-soluble polymer called Guantian, prohexadione calcium, cryptoxanthin, KT-+benzene mycin, food residues, an HDDE-sustained release biological controlled release agent, chlormequat chloride, brassinolide and potassium nitrophenolate by weight. By means of the fertilizer, the absorption speed of crops is high, the selenium content of fruits is stable, the content of heavy metals and non-organic impurities is extremely low, regeneration of crops is fast, the growth vigor is good, the tillering quantity is large, stalks are thick and strong, the rate of blighted grains is small, the yellowing performance is good, crops have disease resistance, drought resistance, cold resistance and lodging resistance, and various diseases are prevented.

The invention provides methods and compositions for the treatment or prevention of animal disease whereby the compositions are biomodulators of plant physiological activity. Inventive methods include administration of one or more biomodulators to an animal such as human for the treatment of cell proliferation or differentiation diseases such as cancer.

The invention relates to a novel drug carrying and delivering system and particularly relate to a formula and a preparation method of an artificial chylomicron containing medicine carrying compound. The artificial chylomicron is prepared from the following main components: an animal oil, a vegetable oil, an oily medicine or an oil-soluble medicine, phospholipid which serves as an emulsifier, cholesterol or steroid which serves as a stabilizer, a shape control agent or a biological modifier, oleic acid or an oleate which serves a stabilizer or a co-emulsifier, fatty monoglyceride and fatty diglyceride which serve as co-emulsifiers, polyethylene glycol phospholipid derivatives (artificial chylomicron membrane protein substitutes) which serve as stabilizers and emulsifiers and are used for prolonging the half-life period of artificial chylomicron in blood, vitamin E which serves as an anti-oxidant; (8) a complex which serves as a controlling metal ion and glycerol or a carbohydrate for regulating the isotonicity of a medicinal preparation.