42 results about "Biomodulators" patented technology

The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step of: (i) producing a gene fragment expression library derived from defined nucleotide sequence fragments; and (ii) assaying the expression library for at least an amino acid sequence derived from step (i) for a biological activity wherein that activity is different from any activity the amino acid sequence may have in its native environment.

The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid.

The invention relates to a biological regulator with a function of increasing fruit setting percentages of fruit vegetables and a method for preparing the biological regulator. The biological regulator comprises, by weight, 6-10 parts of 2, 4-dichlorphenoxyacetic acid, 6-8 parts of diethylaminoethyl hexanoate DA-6, 7-10 parts of forchlorfenuron, 3-5 parts of sodium nitrophenolate, 0.5-1 part of falling preventive elements, 4-5 parts of gibberellin, 8-10 parts of benzylaminopurine, 3-5 parts of dispersing agent ethylene-vinyl acetate copolymers, 2-3 parts of emulsifiers OP-10, 4-6 parts of antifreezing agents ethylene glycol and 100-150 parts of absolute ethyl alcohol. The biological regulator and the method have the advantages that the biological regulator is wide in acting surface and canbe applied to multiple fields; photosynthesis, respiration and substance absorption and translocation of plants can be regulated and controlled, physiological procedures for signal transduction, stoma opening and closing, osmotic adjustment, transpiration and the like can be adjusted, and accordingly growth and development of the plants can be controlled; the biological regulator is low in usage,high in speed and benefit and little in residual toxicity, and only needs to be sprayed once for most fruit vegetables in each season according to set time; the biological regulator rarely can be affected by environments, the fruit setting percentages of the fruit vegetables can be increased by the biological regulator, use modes for the biological regulator are easy and convenient to operate, and the time and labor can be saved.

The present invention relates to methods based on the interactions of thrombin as a biological regulator. More specifically, the invention relates to the interactions of thrombin with regard to Notch signaling, Jagged1, PAR1, and cellular effects mediated thereby. The invention relates to the discovery that thrombin cleaves Jagged1 to produce non-membrane soluble Jagged1 (sJ1). The soluble Jagged1 protein can affect Notch signaling and, among other things, mediate the release of FGF-1 and / or IL-1α from a cell. The invention further relates to the role(s) of thrombin and signaling via Notch proteins and the effect on thrombosis, angiogenesis, and / or differentiation, among other processes. Moreover, the invention relates to discovery that thrombin, sJ1, and TRAP mediate, inter alia, rapid non-classical release of FGF-1, and proteins associated therewith (e.g., p40 Syn1 and S100A13, among others), and the effect growth and proliferation of a stem cell without loss of differentiation potential. Thus, the present invention relates to methods of clonally expanding a pluripotent stem cell while preserving the differentiation potential of the cell, a process termed “stamatogenesis.”

The present invention relates to a compounded chemical preparation for raising adverse resistance of vegetable, fruit tree and crops. Its formula composition includes biological regulating agent 10g, germicide (pesticide) 25-75 g, edible salt 50g, edible vinegar 100g and water 15000g. Besides, said invention also provides its application method.

The invention discloses a preparation method of a bioorganic fertilizer. The method comprises the following steps: 1, preparing a substrate: naturally solarizing or drying pig dung, carrying out ultraviolet lamp irradiation disinfection for 30-120min, and overturning the pig dung 2-3 times in the irritation process to prepare the fermentation substrate; 2, carrying out two stage fermentation: sterilizing the fermentation substrate at 121DEG C for 20-30min, cooling the sterilized substrate to room temperature, adding water, and uniformly stirring to prepare a solid fermentation medium, inoculating a lactobacillus strain liquid, carrying out anaerobic fermentation for 48h, inoculating a Candida utilis strain liquid, introducing aseptic air, and carrying out aerobic fermentation for 48-72h to obtain a fermentation product; 4, drying: drying the fermentation product at 55-60DEG C; and 5, proportioning: adding a biological regulator to the dried fermentation product according to a weight ratio of 100:(0.2-1) in order to prepare the bioorganic fertilizer, wherein the biological regulator is photosynthetic bacteria and azotobacteria. The bioorganic fertilizer prepared in the invention can greatly improve the output per 666.7m<2> of land of crops.

The invention discloses a composite biomass pellet bacterial fertilizer. The composite biomass pellet bacterial fertilizer comprises an enzyme bacterium preparation, sludge of a monosodium glutamate plant, soybean hulls, soybean meal, potassium dihydrogen phosphate for feed, crop straws (fermented), edible bacterial sticks, wheat bran, sweet wormwood herb powder, cystine, brown algae, bentonite, humic acid, a bioregulator, phytase and an appropriate amount of stone dust and water. Through the way, the composite biomass pellet bacterial fertilizer disclosed by the invention is produced by taking the sludge of the monosodium glutamate plant as a culture medium and utilizing wastes. The product has the advantages of low production cost, convenience in manufacturing, a comprehensive effect, high efficiency and balance, as well as nutrition of an organic fertilizer and functions of the composite bacterial fertilizer, thereby having certain economic significance and social significance.

The invention relates to the technical field of agricultural planting, in particular to a biological regulator for soil improvement and a preparation method thereof. The regulator is prepared from lime, bentonite, polyvinyl akohol, polyacrylic acid, plant straw, animal dung, potassium fulvic acid, stellera chamaejasme, a flaccid knotweed herb, calamus, green bristlegrass herb, tobacco, mugwort and strains. A preparation method comprises the steps that the plant straw, the stellera chamaejasme, the flaccid knotweed herb, the calamus, the green bristlegrass herb, the tobacco and mugwort are weighed and smashed, the mixture is put in a fermenting tank, the animal waste, the plant ash, the potassium fulvic acid and the lime are added, and then the fermenting strains and water are added for natural fermentation; after fermentation is completed, the bentonite, the polyvinyl akohol and the polyacrylic acid are added, and even mixing is performed to obtain the regulator. The regulator can effectively regulate a soil nutrition structure, can also effectively kill injurious insects in soil and provides guarantee for healthy growth of stevia rebaudiana, and the preparation method of the regulator is simple and convenient to operate and has a good application value.

Bio-regulators from a group of quaternary ammonium moieties modify a gene expression in undesirable plants to inhibit growth and robustness and enhance the effectiveness of herbicides. Such bio-regulator may be applied to plants through seed treatments, root drenching, spraying and dusting, or to soil were desirable crops are planted or will be planted. Bio-regulators may be duel-acting; causing beneficial modification to gene expressions in desirable plants while modifying gene expression in undesirable plants, making them more susceptible to herbicides. Bio-regulators are Ester Compounds, BMIA Compounds or related salts of those compounds.

Bio-regulators from a group of quaternary ammonium moieties modify a gene expression in a plant to induce enhanced growth and robustness. Such bio-regulator may be applied to seeds through coating or encapsulating, to plants through root drenching, spraying and dusting. Bio-regulators may be duel-acting; causing beneficial modification to gene expressions in desirable plants while modifying gene expression in undesirable plants, making them more susceptible to herbicides. Bio-regulators are Ester Compounds, BMIA Compounds or related salts, BMIA Compounds or related salts of those compounds.

The invention relates to a novel drug carrying and delivering system and particularly relate to a formula and a preparation method of an artificial chylomicron containing medicine carrying compound. The artificial chylomicron is prepared from the following main components: an animal oil, a vegetable oil, an oily medicine or an oil-soluble medicine, phospholipid which serves as an emulsifier, cholesterol or steroid which serves as a stabilizer, a shape control agent or a biological modifier, oleic acid or an oleate which serves a stabilizer or a co-emulsifier, fatty monoglyceride and fatty diglyceride which serve as co-emulsifiers, polyethylene glycol phospholipid derivatives (artificial chylomicron membrane protein substitutes) which serve as stabilizers and emulsifiers and are used for prolonging the half-life period of artificial chylomicron in blood, vitamin E which serves as an anti-oxidant; (8) a complex which serves as a controlling metal ion and glycerol or a carbohydrate for regulating the isotonicity of a medicinal preparation.