79 results about "Population structure" patented technology

The invention provides a system and methods for the determination of the pharmacogenomic phenotype of any individual or group of individuals, ideally classified to a discrete, specific and defined pharmacogenomic population(s) using machine learning and population structure. Specifically, the invention provides a system that integrates several subsystems, including (1) a system to classify an individual as to pharmacogenomic cohort status using properties of underlying structural elements of the human population based on differences in the variations of specific genes that encode proteins and enzymes involved in the absorption, distribution, metabolism and excretion (ADME) of drugs and xenobiotics, (2) the use of a pre-trained learning machine for classification of a set of electronic health records (EHRs) as to pharmacogenomic phenotype in lieu of genotype data contained in the set of EHRs, (3) a system for prediction of pharmacological risk within an inpatient setting using the system of the invention, (4) a method of drug discovery and development using pattern-matching of previous drugs based on pharmacogenomic phenotype population clusters, and (5) a method to build an optimal pharmacogenomics knowledge base through derivatives of private databases contained in pharmaceutical companies, biotechnology companies and academic research centers without the risk of exposing raw data contained in such databases. Embodiments include pharmacogenomic decision support for an individual patient in an inpatient setting, and optimization of clinical cohorts based on pharmacogenomic phenotype for clinical trials in drug development.

The invention relates to the technical field of movement positioning data analysis in a sense network environment, and discloses a movement position analysis system and method in the sense network environment for performing clustering analysis and knowledge discovery on positioning data by orienting positioning data acquired by a mobile device and combining with other additional information. The movement position analysis method in the sense network environment comprises the steps of: receiving positioning data points sent by one or more locatable devices; performing data correlation on the positioning data points and population structure characteristic data as well as user historical trajectory data; performing clustering analysis on the correlated positioning data points, aggregating users with similar characteristics into a group so as to obtain group structure characteristic data; exporting an aggregated result. According to the method, mobile users with similar characteristics can be aggregated to form a group based on the positioning data and other information, and the group information can be shown on a user terminal or a public display device in a friendly way.

The invention relates to a method for constructing a high-yielding cotton population structure of a jujube and cotton intercropping drip irrigation cotton field in Xinjiang. The method includes steps of creating a suitable population environment in the drip irrigation high-yielding cotton field; preparing seeds; sowing the seeds; irrigating; applying fertilizers; chemically regulating the cotton field; controlling diseases, insects and weeds; performing topping; and harvesting and the like. The method has the advantages that the high-yielding cotton population structure of the jujube and cotton intercropping drip irrigation cotton field in Xinjiang can be constructed; and as shown by investigation for a plurality of fields, specific indexes of the high-yielding population structure include that the maturity of selected cotton varieties is 5-8 days earlier than the maturity of local mono-cropping main cotton varieties, the period between a sowing stage and a boll opening stage is 148-156 days, cotton reaches the boll opening stage on 12-20 September under a jujube and cotton intercropping condition, the cotton assuredly reaches the boll opening stage on 12-20 September under the jujube and cotton intercropping condition, the maximum leaf area index is 3.9-4.3, the plant height is 69-77cm, the plant width is 51-58cm, the light interception rate of the cotton at a peak polling stage is higher than 80%, the fruit branch number is 8.6-9.2, the number of unit-plant bolls is 3.9-4.3 per plant, the actual number of harvesting plants is 15380-17450 per mu (net area), and the boll yield is 61581-71337 per mu.

The invention relates to high-quality dark green tea and a processing technique thereof. The processing technique comprises the steps of pile fermentation, tea steaming, fermentation inducer adding, tea leaves pressing, tea leaf fermentation, drying and the like; in the step of pile fermentation, raw dark green tea is added with fresh tea leaf homogenate with high enzyme activity to effectively promote transformation of tea leaf matrix and flavor substance during pile fermentation and provide beneficial growth matrix for eurotium cristatum and other beneficial microorganisms in the fermentation process; the high-efficiency fermentation inducer composed of eurotium cristatum and hansenula debaryomyces hansenii is added to improve the purity of the microbial population, improve the microbial population structure and enable the fermentation period to be shortened to be 3-5 days, the high-quality dark green tea has dense golden flowers and rich arohid flavor, the quality of fu brick tea is remarkably improved and the processing cost is reduced; the environment temperature and the environment humidity in the fermentation process are controlled optimally, the beneficial microorganism population growth is promoted and the quality and the flavor of finished tea are effectively improved.

The present invention relates to a soil conditioning agent using oyster shell as main material, and it is characterized by that it is formed from oyster shell powder, polyaspartate, chitosan or its derivative and biological total or partial powder or fermentation material, their weight percentages respectively are 50-70, 2-5, 1-3 and 25-45. The described biological total or partial powder or fermentation material include upland plant total or their root, stem, leaf, flower, fruit and shell powder or fermentation material and total or partial powder of marine biotas of fish, shrimp, shellfish and algae or fermentation material. Said invention can regulate soil microbial population structure, can increase number of beneficial bacteria, raise fertilizer utilization rate, raise yield of crops and improve quality of crops.

The invention relates to a method for preparing an enhanced liquid microbial organic fertilizer. The method comprises the following steps of: mixing rotten compost products and water in a volume ratio of 1:8-10 in an opened barrel container; inoculating microbial agents; fermenting the mixture under an intermittent aerobic environment at the room temperature of between 20 and 25 DEG C; and filtering the mixture with a 100-mesh screen to obtain the organic fertilizer. The method has the advantages that: the method takes the rotten compost products such as cow dung, chicken dung and rice strawsas raw materials; and the obtained liquid fertilizer contains mineral elements such as quick-acting and slow-acting carbon, nitrogen, phosphorus and potassium elements which are necessary to crop growth, and a great number of aerobic microorganisms and metabolic products thereof. In the process of liquid fermentation, endogenous bacillus subtilis bacteria which can be colonized in plants are inoculated, so that the organic fertilizer has the advantages of more specific functions, stronger target property and more stable effect. The organic fertilizer also has the advantages of simple fermentation process equipment, simple fermentation process, easy operation, capabilities of improving soil quality, balancing soil nutrients and enriching population structures of soil microorganisms after application, and effects of promoting growth and preventing diseases for crops.

The invention discloses a method for separating dominant rotifers and co-culturing the dominant rotifer and chlorella vulgaris in an O3/BAC (biological activated carbon) advanced treatment process, which comprises the following steps of: a. determining the rotifers in the O3/BAC advanced treatment process: researching population structures of planktonic animals in various process flows of waterplant ozone activated carbon advanced wastewater treatment, sampling and respectively quantitatively and qualitatively analyzing; b. separating the dominant rotifers in the O3/BAC advanced treatment process: acclimating in dark at room temperature over night, picking up health and lively adults by using a dropper for further culturing; c. culturing the chlorella vulgaris: grafting purified single chlorella vulgaris in a Blue-Green Medium culture solution; d. carrying out adaptability on the rotifers: directly grafting the rotifers with the initial grafting density of 10-30/L in the cultured chlorella vulgaris solution; e. co-culturing: co-culturing according to the initial grafting density of the rotifers; and f. subcultring: if the rotifers in a culturing system is dead, transiting the rotifers for subcultring. Co-culturing the dominant rotifers indoors for a longer time in the O3/BAC advanced treatment process is realized, and the density of the rotifers is maintained at 400-600 ind/ml. Particularly, experimental material is provided for safety control and risk assessment research of the rotifers in life drinking water.

The invention provides a compound biological agent for restoring contaminated soil, belongs to the technical field of soil restoration and particularly relates to the compound biological agent for restoring polycyclic aromatic hydrocarbon contaminated soil. The compound biological agent provided by the invention comprises a soil conditioner which can improve the permeability of the soil and increase the transmission quantity of oxygen in the soil, thereby rapidly establishing a healthy microbial population structure. The compound biological agent further comprises a mixture of different compound microorganism strains. The compound biological agent provided by the invention has the double effects of restoring a soil ecosystem and degrading polycyclic aromatic hydrocarbons.

The invention discloses a bean yoghourt fermenting agent with processing suitability as well as a preparation method and application thereof, and belongs to the field of bioengineering. The preparation method of the bean yoghourt fermenting agent with the processing suitability comprises the following steps: an exogenous microbial population is added into reconstituted milk, and the exogenous microbial population, the reconstituted milk and Kefir grains are mixed and fermented; after multi-generation domestication, a Kefir fermenting agent is reformed, so that the microbial population structure of the reformed Kefir fermenting agent is changed, and the reformed Kefir fermenting agent is used for fermenting bean milk so as to produce bean yoghourt; soybean isoflavone can be biologically converted, so that concentration of genistein and daidzein in the bean yoghourt is improved; the reformed Kefir grains are adopted to prepare the fermenting agent so as to ferment the beam milk, so that the Kefir bean yoghourt is smooth in taste and rich in nutrition, absorption and utilization of vegetable protein for a human body can be improved, and probiotics in the bean yoghourt is increased; the soybean isoflavone can be biologically converted, so that the concentration of the genistein and the daidzein in the bean yoghourt is improved, and the bioavailability of the soybean isoflavone is improved.

The invention relates to the technical field of crop planting agricultural methods, and discloses a construction method of a drip irrigation spring wheat super-high-yield population structure. The method comprises the following steps: preparing a spring wheat variety and making pre-sowing preparations; performing wide-narrow row configuration, wherein the widths of wide rows are 20 centimeters, the widths of narrow rows are 12.5 centimeters, and drip irrigation zones are paved between adjacent wide rows; sowing; performing field management from a seeding stage to a tillering stage, from a jointing stage to a booting stage, from a heading stage to a fertilization stage, from the fertilizing stage to a seed formation stage, and from a milk-ripe stage to a full ripening stage. The construction method provided by the invention is economical and practical; a drip irrigation technology is adopted, and dry-sowing and wet-emergence are adopted, so that the field emergence rate is 90-95 percent; the wide-narrow row configuration is adopted, so that the ventilation and light transmittance rates of a wheat field can be increased; the plant heights and the basic internode lengths of main stems can be controlled through chemical regulation and control at the tillering stage; from the heading stage to the milk-ripe stage, fertilization is performed along with water drops, and fertilizers are moved backwards, so that the function periods of leaves and root systems can be prolonged, the influence of fertilizer removal at the milk-ripe stage on the yield is avoided, and large-scale high yield and super high yield of drip irrigation spring wheat are ensured.

The invention discloses an image segmenting method based on a dynamic multi-population integrated differential evolution algorithm. According to the method, sub-populations are divided and redistributed by adopting an original population in the aspect of population structure planning so as to guarantee the diversity of a population evolution process and avoid a local optimum phenomenon; local search variation is combined with global search variation in the variation strategy so as to achieve a balance between an optimal threshold of population survey and accelerated convergence; and the shortcomings caused by fixed parameters of a standard differential evolution algorithm are effectively overcome through the parabolic dynamic incremental change of a cross probability factor. Compared withother evolutionary algorithms on a benchmark test set, the improved algorithm has the advantage that the optimization and convergence speed can be obviously and significantly improved; and the improved differential evolution algorithm has a significant effect in accuracy and speed when being applied to image segmentation.

The invention discloses a novel hydrophilic anti-pollution polyvinylidene fluoride flat membrane, and a preparation method and application thereof, and belongs to the fields of water treatment and environmental functional materials. A matrix of the flat membrane comprises nano titanium dioxide and graphene oxide, and the mass ratio of the graphene oxide to the nano titanium dioxide is 1:(1-5). Thepreparation method of the flat membrane comprises the following steps: 1) preparing a membrane casting solution, concretely adding graphene oxide powder and nano silicon dioxide into a dimethylacetamide solvent, carrying out ultrasonic dispersion to obtain a dispersion liquid, then adding polyvinylidene fluoride and a pore-foaming agent polyvinylpyrrolidone into the dispersion liquid, and carrying out heating and stirring for a reaction to prepare the membrane casting solution; and 2) preparing a finished product film. Filtration performance, hydrophilicity, mechanical strength and bacteriostasis performance of the flat membrane provided by the invnetion are excellent, the microbial population structure in a membrane bioreactor (MBR) cannot be influenced, growth of microorganisms cannot be inhibited, and popularization is facilitated.

The invention discloses a cabbage type rape grain weight-associated molecular marker and a preparation method and an application thereof. The preparation of the molecular marker comprises the following steps: 1) by the utilization of 91 unit points of SSR markers uniformly distributed on an oilseed rape genetic map, 576 varieties of oilseed rape from all around the world undergo genotype and population structure analysis and association analysis is carried out with the combination of thousand grain weight data character data; 2) 14 high-quality SSR markers are developed near the marker BrSF7-181 by the utilization of cabbage and oilseed rape whole genome sequence information so as to carry out association analysis once again, wherein BrSF6-2025 has the highest significance level; and 3) by the utilization of the molecular marker, grain weight extreme varieties in genetic resource populations are verified. The invention provides a new genetic marker for molecular breeding of rape grain weight and also provides useful information for map-based cloning of cabbage type rape grain weight genetic locus.

The invention discloses a chrysanthemum salt-tolerance associated molecular marker and an obtaining method and application thereof. The obtaining method comprises the steps that a, salt-tolerance identification is performed for two consecutive years; b, chrysanthemum variety population structure analysis is performed; c, chrysanthemum variety genetic relationship analysis is performed; d, the molecular marker closely associated with chrysanthemum salt-tolerance is determined. According to the obtaining method, genome-wide molecular marker scanning is performed on 159 cut-flower chrysanthemum varieties by utilizing the three molecular marker technologies of SRAP, SCoT and EST-SSR at the same time, the number of obtained dyed strips is large, the dyed strips are good in polymorphism and high in reproducibility, and the molecular marker which is closely associated with salt-tolerance can be obtained. Three marker loci detected through the obtaining method are remarkably associated with salt-tolerance of varieties and provide a certain reference for chrysanthemum salt-tolerance molecular marker-assisted selection.

The present invention relates to a darkening and stink river ecosystem reconstruction integration method, which comprises online water quality detection, exogenous pollutant control, endogenous pollutant control, biodiversity restoration, ecological sustainable construction, and a remote intelligent monitoring system, wherein the online water quality detection performs water quality detection on a target water body, the exogenous pollutant control reduce the entering of exogenous pollutants into the target water body, the endogenous pollutant control performs repairing treatment on the target water body, the biodiversity restoration adjusts the microbial flora structure, the fish population structure and density of the target water body, the ecological sustainable construction constructs riverside emerged plants by using an artificial ecological island, and the remote intelligent monitoring system performs the remote supervision and control on the operation condition of the treatment system. According to the present invention, the darkening and stink river ecosystem reconstruction integration method cannot cause secondary pollution to the water body, can promote the water body to restore the self-repair function, and can strengthen the self-purification ability of the water body.

The invention relates to a method for optimum design of gear reducers on the basis of a clustering multi-objective estimation of distribution algorithm, and aims at solving the problems that the local search ability of the existing multi-objective estimation of distribution algorithm is not sufficiently utilized in the multi-objective optimization problem solving process, abnormal solutions are directly discarded in the solving process, the population diversity is easy to lose and too much calculation overhead is used for constructing an optimum probability model. The method comprises the following steps of: firstly dividing a population into a plurality of local classes by utilizing an agglomerative hierarchical clustering algorithm; randomly selecting a unity from each local class to form a global class; and constructing a Gaussian model for each unity to approach a population structure and carrying out sampling to generate a new unity, wherein the mean value of the Gaussian model is the unity, and a covariance matrix is a covariance matrix of the local class where the unity is located or a covariance matrix of the global class. The method disclosed by the invention is used for the field of spaceflight.

The invention discloses a breeding method of female yaks in cold season in the alpine region and belongs to the technical field of breeding of the yaks. In the method, the pregnancy rate of the femaleyaks is greatly increased, the female yaks are strong physically, and the miscarriage prevention rate, weight of born calves and production performances of milk yield are greatly increased by optimizing a herd population structure, adopting special feed for supplementary feeding in the cold season, providing environment-suitable worm sheds and adopting measures of expelling worms, invigorating stomach and the like; meanwhile, recovery of the female yaks can be sped up, fat loss of the yaks in the cold season is reduced, and the short-term fattening goal is achieved; a traditional yak breedingmode is reformed, high yield, high quality and efficient development of the animal husbandry are realized, turnover of the herd population is quickened, and production performance of the yaks is improved.

The invention discloses a bioleaching strain breeding method for copper ore agitation leaching. The method comprises the following steps: preparing a certain amount of bioleaching strain population by enrichment culture of bioleaching strains; adaptively culturing under a condition that the concentration of ore pulp gradually increases to ensure that the bioleaching strain population can adapt to a biological wet leaching environment with high concentration of the ore pulp under agitation; adopting culture medium suitable for chemical industrial production in bulk to reduce the culture cost of the leaching strain population; and identifying the prepared leaching strain population by utilizing the microarray technology of analyzing the strain population structure so as to obtain the high-efficiency leaching strain combination suitable for copper ore agitation leaching.

The invention discloses a novel anti-flowering-cabbage-downy-mildew biofertilizer and a preparation method thereof. The biofertilizer comprises the following components in parts by mass: 20-50 parts of lophatherum gracile, 50-70 parts of chicken manure, 1-10 parts of biochar and 1-10 parts of bamboo cuttings. The novel biofertilizer is specially developed for the flowering cabbage downy mildew; and the lophatherum gracile and bamboo cuttings used as main components have favorable inhibiting actions on pathogenic fungi, and are beneficial to reducing the occurrence of the flowering cabbage downy mildew. According to the novel anti-flowering-cabbage-downy-mildew biofertilizer, the added composite microbial inoculant has the effects of resisting diseases and promoting growth, and especially, all strains in the composite microbes have favorable resistance to flowering cabbage downy mildew, thereby effectively preventing the flowering cabbage downy mildew, and reducing the consumption of chemical pesticides. The fertilizer has high microbe content, can improve the microbial population structure in soil, and further reduces the occurrence of other diseases and pests.

The invention relates to a population prediction method for optimizing a Leslie model based on a genetic thought, and the method comprises the steps: taking time and age as parameters, carrying out the discretization of the time at the same age interval, and building an initial model; introducing a genetic thought and combining with the initial model to calculate the proportion of the non-unisexual women and the proportion of the non-unisexual women of the male at a certain time period; calculating the wish fertility of the females at a certain time period or the total number of the next generation of females obtained after fertility, and further obtaining the total fertility rate; constructing a dynamic planning model in combination with the Leslie model; making reasonable population quantity, population structure, total growth rate and tending ratio prediction according to the dynamic planning model; on the basis of less data, and accurately predicting the future development trend ofthe population and the change trend of the population structure under a growth policy.

The invention provides a medium/trace element granular fertilizer and belongs to the technical field of medium/trace element fertilizers. The medium/trace element granular fertilizer comprises the following raw materials in parts by weight: 70-92 parts of oyster shell powder, 5-10 parts of calcined oyster shell powder, 10-40 parts of magnesium sulfate monohydrate and 0.5-6 parts of an alga activesubstance. The medium/trace element granular fertilizer provided by the invention is comprehensive in medium/trace element type, good in effectiveness, capable of replenishing medium/trace elements carried away by crops from soil in time and comprehensively, and thus has good effects that a healthy environment is provided for crops to grow, the nutrition is balanced, the yield of crops is increased and the quality is improved. In addition, the oyster shell powder in the medium/trace element granular fertilizer provided by the invention is of a micro hole structure, microbial population structures of soil can be regulated, the number of beneficial bacteria can be increased, meanwhile, plant root systems can be developed, plants can grow strongly, the crop resistance can be improved, and theyield can be increased. In addition, together with a basic fertilizer, the medium/trace element granular fertilizer provided by the invention can be used in modes of bottom application and throwing,and is convenient to use.