To provide a method for delivering a compound to the
skin of a subject.SOLUTION: A method for delivering a compound to the
skin of a subject includes topically applying an effective
dose of one or more biphasic lipid vesicles to the
skin of the subject, where the biphasic
lipid vesicle contains one or more infiltration accelerators including (i) the compound and (ii) one or more nonionic detergents having approximately 10 or less of hydrophilic-lipophilic balance (HLB), and the one or more nonionic detergents having approximately 10 or less of HLB contains dimonomethylether
oleyl ether,
sorbitan monopalmitate, or polyoxyethylene (4) dilaurate.SELECTED DRAWING: Figure 1A-1