The invention belongs to the technical field of chemicals and discloses a method for preparing a cyclopentane refrigerant. Efficient separation of cyclopentane from 2,2-dimethyl butane is achieved byusing an extraction distillation technique with acetonitrile as an extraction agent. The method for preparing the cyclopentane refrigerant comprises the following steps: by taking a C5 mixture as a raw material, carrying out light component desorption, heavy component desorption, extraction distillation and desorption; by taking acetonitrile as an extraction agent, feeding a material from the topof a heavy component desorption tower into the middle part of an extraction distillation tower; feeding the extraction agent into the upper part of the extraction distillation tower, collecting 2,2-dimethyl butane from the top of the tower, and desorbing an enriched solvent at the bottom of the tower in a desorption tower, thereby obtaining the cyclopentane refrigerant. By adopting the method forpreparing the cyclopentane refrigerant, the obtained cyclopentane has purity not less than 99%, and is low in water content. The extraction agent is good in stability, high in selectivity, low in solvent ratio, low in boiling point, simple in process procedure, high in operation controllability, low in energy consumption, high in product purity, possible in extraction agent circulation, small in pollution and applicable to industrial production. The method is applicable to preparation of high-quality cyclopentane, and is particularly applicable to preparation of cyclopentane refrigerants of environmental-friendly refrigerators.