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Preparation method and use of alpine yarrow herb ketoacid

A technology of artesinone acid and monomer is applied in the field of preparation and application of artesinone acid, and can solve the problems of poor recovery of liver disease, liver damage and the like

Inactive Publication Date: 2007-09-26
斯拉甫·艾白
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

In addition, many drugs must be oxidized, decomposed, and excreted in the liver, and some can directly cause liver damage, which is not conducive to the recovery of liver disease

Method used

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  • Preparation method and use of alpine yarrow herb ketoacid
  • Preparation method and use of alpine yarrow herb ketoacid
  • Preparation method and use of alpine yarrow herb ketoacid

Examples

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Embodiment

[0017] (1) The preparation method and application of Artemisinic acid, the preparation of Artemisinic acid by conventional chromatography and liquid phase combination method, firstly carry out raw material treatment: after crushing the whole Artemisia japonica, reflux extraction with 95% ethanol for 4 times, The time is 1-5h, 30min-4h, 15min-2h, 30min-5h, then the extracts are combined, concentrated under reduced pressure into a paste, extracted 3 times with ethyl acetate, the extract is concentrated and mixed on silica gel to 100-200 mesh Silica gel column, eluted with petroleum ether 30-60°C-ethyl acetate 3:1, V / V, and the eluted product was concentrated for later use; Standard preparation: Dissolve the chromatographic crude product in methanol solution, ultrasonic 30min, and use Purified by semi-preparative high performance liquid chromatography, collected components with a retention time of 18.5 min, concentrated them under reduced pressure at 60°C, and dried them in a cons...

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Abstract

The invention relates to a preparation method for bullatine keto acid combined with common chromatography and liquid phase, which comprises: smashing material to reflux extract with alcohol, mixing extracted liquid to concentrate into paste-shape and extract with ethyl acetate; mixing silicon gel of 100-200 items; eluting with ligarine- ethyl acetate; dissolving coarse product in carbinol solution, purifying with HPLC; collecting saving constituent to decompress and concentrate in constant temperature drying box. This product benefits in inhibiting hepatitis B.

Description

technical field [0001] The invention relates to a preparation method and a pharmaceutical application of schizo-artemisinic acid, in particular to the pharmaceutical application of inhibiting hepatitis B virus and protecting the liver. Background technique [0002] Viral hepatitis and liver injury are diseases that damage human health. Among them, viral hepatitis is a global infectious disease that seriously endangers human health. The prognosis of patients is poor. Most patients become chronic and may develop into liver cirrhosis. Liver damage caused by viral hepatitis is mainly mediated by the body's immune response. When the virus activates the body's immune system, it produces sensitized lymphocytes and specific antibodies, especially virus-specific cytotoxic T cells. They can not only react with the virus in the body to kill, but also cause liver damage due to the viral antigen on the surface of the virus-infected liver cells, leading to degenerati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C59/82C07C51/48A61K31/19A61P1/16A61P31/14
Inventor 斯拉甫·艾白哈木拉提·吾甫尔阿吉艾克拜尔·艾萨
Owner 斯拉甫·艾白
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