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Water soluble preparation of domperidone and production thereof

A domperidone, water-soluble technology, applied in sexual diseases, pharmaceutical formulations, organic active ingredients and other directions, can solve the problems of low bioavailability, drug accumulation, easy needle insertion, etc., and achieves high bioavailability, simple preparation method, and application wide range of effects

Inactive Publication Date: 2007-10-24
宋艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Domperidone is fat-soluble, insoluble in water, low in bioavailability, poor in efficacy, easy to plug the needle for injection, and easy to cause local drug accumulation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of Example 1 of the present invention is made of the following raw materials by weight:

[0017] Domperidone 30,

[0018] Glycine 5,

[0019] Citrate 10,

[0020] Ion-free distilled water 1000.

[0021] The preparation method of present embodiment 1 preparation is:

[0022] 1), ingredients in proportion;

[0023] 2) Add ion-free distilled water to glycine and structural acid, add domperidone after heating to dissolve, and stir and react at a constant temperature of 80°C for 40 minutes to form a transparent liquid water-soluble preparation.

Embodiment 2

[0025] Example 2 preparation of the present invention is made of the following raw materials by weight:

[0026] Domperidone 150,

[0027] Leucine 20,

[0028] Maleic acid 20,

[0029] Ion-free distilled water 1000.

[0030] The preparation method steps of present embodiment 2 preparations are as follows:

[0031] 1), ingredients in proportion;

[0032] 2) Add ion-free distilled water to leucine and maleic acid, heat to dissolve, add domperidone, stir and react at a constant temperature of 60°C for 60 minutes, and form a transparent liquid water-soluble preparation.

Embodiment 3

[0034] Domperidone 300,

[0035] Lysine 30,

[0036] Tartaric acid 30,

[0037] Ion-free distilled water 1000.

[0038] The preparation method of present embodiment 3 preparation comprises the steps:

[0039] 1), ingredients in proportion;

[0040] 2) Add ion-free distilled water to lysine and tartaric acid, heat to dissolve, add domperidone, stir and react at a constant temperature of 100°C for 60 minutes, and form a transparent liquid water-soluble preparation.

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PUM

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Abstract

A water-soluble domperidone for improving the genitality of animals is proportionally prepared from domperidone, amino acid, weak acid, and non-ionic distilled water. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a water-soluble preparation of domperidone and a preparation method thereof. Background technique: [0002] Domperidone is a dopamine receptor antagonist that can increase the sensitivity of gonadotropin-releasing hormone (GnRH) receptors and at the same time inhibit the negative feedback of sex steroid hormones (estrogen E. progesterone P. estrogen T). It is used to enhance the positive effect of (GnRH) in reproduction and promote reproduction. Domperidone is fat-soluble, insoluble in water, has low bioavailability, poor drug efficacy, easy to plug the needle for injection, and easily causes local drug accumulation. Invention content: [0003] The purpose of the present invention is to overcome the above disadvantages and provide a water-soluble preparation of domperidone that can improve the reproductive potential of animals and has a wide range of applications. Another object of the present invention is to provide a met...

Claims

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Application Information

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IPC IPC(8): A61K31/454A61K9/08A61P15/08
Inventor 宋艳
Owner 宋艳
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