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Blood filter material and process for preparing same

A technology of blood filtration and manufacturing method, which is applied in the field of blood filtration materials and its manufacture, can solve problems such as heterogeneous reaction of blood and decline in blood quality, and achieve excellent blood compatibility, shortened start-up time, and high blood compatibility Effect

Inactive Publication Date: 2007-11-07
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the polysaccharide-type coating modifier will cause a heterogeneous reaction in the blood, and the platelets will be activated, resulting in a decrease in blood quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] After the sericin on the cocoon surface was removed by the alkaline method, 29.6 grams of white silk protein obtained therein was put into 266.4 grams of 47% (percentage by weight) lithium bromide aqueous solution at 20° C., and the silk protein was dissolved after 22 hours. A silk fibroin / lithium bromide aqueous solution with a silk fibroin content of 10% is formed, diluted with water for 3 times, filtered, and passed through a dialysis bag to remove lithium bromide. Obtaining silk fibroin content is 1480 grams of the silk fibroin aqueous solution of 2% (percentage by weight).

[0026] Get the above-mentioned 450 grams of 2% (weight percent) silk fibroin aqueous solution and 4 grams of solid content (weight percent) as 25% medical grade polyurethane aqueous solution and stir for 5 minutes at a temperature of 20 ° C to obtain the silk fibroin used in the coating. / Polyurethane blending aqueous solution 454 grams.

[0027] At a temperature of 20°C, pour the above-mentio...

Embodiment 2

[0029] After the sericin on the surface of silkworm cocoons is removed by soap boiling, 10 grams of white silk protein obtained therein is put into 200 grams of 47% (percentage by weight) lithium bromide aqueous solution at 25° C., and the silk protein dissolves after 15 hours. , forming a silk fibroin / lithium bromide aqueous solution with a silk fibroin content of 5% (percentage by weight), adding water to dilute 2 times, filtering, and removing lithium bromide through a dialysis bag. Obtaining silk fibroin content is 625 grams of the silk fibroin aqueous solution of 1.6% (percentage by weight).

[0030]Get the above-mentioned 625 grams of 1.6% (weight percent) silk fibroin aqueous solution and 300 grams of solid content (weight percent) as 30% medical grade polyurethane aqueous solution and stir at 25 ℃ for 8 minutes to obtain the silk fibroin used for coating / Polyurethane blending aqueous solution 925 grams.

[0031] At 25°C, take the above silk fibroin / polyurethane blend...

Embodiment 3

[0033] After the sericin on the cocoon surface was removed by the alkaline method, 20 grams of white silk protein obtained therein was put into 250 grams of 50% (percentage by weight) lithium bromide aqueous solution at 30° C., and the silk protein was dissolved after 15 hours. A silk fibroin / lithium bromide aqueous solution with a silk fibroin content of 8% (percentage by weight) is formed, diluted 2.5 times with water, filtered, and the lithium bromide is removed through a dialysis bag. Obtaining silk fibroin content is 1430 grams of the silk fibroin aqueous solution of 1.4% (percentage by weight).

[0034] Get the above-mentioned 50 grams of 1.4% (weight percent) silk fibroin aqueous solution and 14 grams of solid content (weight percent) as 20% medical grade polyurethane aqueous solution and stir at a temperature of 30 ° C for 8 minutes to obtain the silk fibroin used in the coating. / Polyurethane blending aqueous solution 64 grams.

[0035] At a temperature of 30°C, pour...

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PUM

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Abstract

The invention relates to a blood filtering material and its preparation method. The material is formed from filtration substrate and surface modified layer, wherein the filtration substrate is macromolecular nonwoven material processed by using melt-blowing method with density of 10-1000g / cm2, mean pore size of 0.1-100 mu m, thickness of 0.01-50mm, fiber diameter of 0.01-50 mu m; surface modified layer is formed from fibroin protein and polyurethane blended aqueous solution in 90-10:10-90 by weight; Conventional coating method is adopted, comprising blending medical polyurethane aqueous solution and self-made fibroin protein, applying the above blend on the surface of filtration substrate, drying, bonding, and curing. In the invention, the price of raw materials is low, and the products are provided with excellent blood compatibility, wettability, permeability and high filter efficiency which can be used as blood filtering materials.

Description

Technical field: [0001] The present invention relates to a blood filter material and a manufacturing method thereof, in particular to a blood filter material and a manufacturing process thereof which use a silk fibroin / polyurethane blended aqueous solution as a coating agent for surface coating modification Background technique: [0002] Blood is one of the basic substances necessary to maintain human life activities. The components of blood include plasma and blood cells. Blood cells can be divided into red blood cells (6-9.5 μm), white blood cells (6-20 μm) and platelets (about 2 μm). Although blood type matching is considered in blood transfusion medicine, various transfusion reactions often occur due to transfusion of blood or blood components containing leukocytes, such as non-hemolytic febrile reaction, adult respiratory distress syndrome, platelet transfusion tolerance, etc.; In addition, viruses transmitted by blood transfusion, such as hepatitis B virus, hepatitis ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D39/16B01D39/08
Inventor 王洪靳向煜吴海波殷保璞金雍炜
Owner DONGHUA UNIV