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Medicine composition of refreshing solid dispersion and its preparation and preparing process

A technology of solid dispersion and Xingnaojing is applied to Xingnaojing solid dispersion pharmaceutical composition and preparation thereof. Defects in the extraction of active ingredients and preparation of Xingnaojing injection

Inactive Publication Date: 2008-07-16
托新权
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And there is certain defective in existing preparation technology (Ministry of Health's Chinese patent medicine preparation ministerial standard 17th subvolume), especially only adopt steam distillation to valuable medicine musk, turmeric, gardenia also just steam distillation, do not have Extracting active ingredients such as curcumin and geniposide has caused a great waste of medicinal materials, so the current Xingnaojing injection process needs to be improved and improved
The Chinese patent application number 200410097167.0 discloses a pharmaceutical composition for the treatment of diseases such as meningitis and hepatic coma. The 17th volume of the standard) was completed through drug modification, and there were also defects in the preparation process of Xingnaojing Injection. No new treatment method was proposed for the volatile medicinal materials musk and borneol in the composition, and the active ingredients curcumin and geniposide There is no extraction, no reliable technical guarantee for the retention of important active ingredients, and no quantitative indicators for the control of active ingredients

Method used

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  • Medicine composition of refreshing solid dispersion and its preparation and preparing process
  • Medicine composition of refreshing solid dispersion and its preparation and preparing process
  • Medicine composition of refreshing solid dispersion and its preparation and preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] prescription composition

[0050] Musk 3750mg, borneol 500mg, turmeric volatile oil 0.5ml, turmeric total curcumin 200mg, gardenia total glycosides 200mg, PEG6000 6975mg

[0051] preparation

[0052] In a closed device with a cooling cycle heating and heat preservation system, polyethylene glycol is heated and melted, and then the right gardenia glycosides, curcumin, turmeric volatile oil, musk paste, and borneol powder are added, and advanced high-shear Homogenization technology disperses each component evenly, and drips it at 80-90°C, and drips the medicine liquid kept at 80-90°C into the mixed cooling liquid, the dropping speed is 40-80 drops / min, and the cooling liquid is The mixture of simethicone and liquid paraffin, the ratio of the two is (0~4):(10~6), using gradient cooling, the uppermost 15 cm to 20 cm is controlled at 0 ° C to 5 ° C, and the middle section is 0 ° C ~-5°C, the end 20cm is controlled at -5°C~-10°C, the drop distance (the distance from the dri...

Embodiment 2

[0054] prescription composition

[0055] Musk 3750mg, borneol 500mg, turmeric volatile oil 1.0ml, turmeric total curcumin 250mg, gardenia total glycosides 250mg, PEG6000 7502mg

[0056] preparation

[0057] In a closed device with a cooling cycle heating and heat preservation system, polyethylene glycol is heated and melted, and then the right gardenia glycosides, curcumin, turmeric volatile oil, musk paste, and borneol powder are added, and advanced high-shear Homogenization technology disperses each component evenly, and drips it at 80-90°C, and drips the medicine liquid kept at 80-90°C into the mixed cooling liquid, the dropping speed is 40-80 drops / min, and the cooling liquid is The mixture of simethicone and liquid paraffin, the ratio of the two is (0~4):(10~6), using gradient cooling, the uppermost 15 cm to 20 cm is controlled at 0 ° C to 5 ° C, and the middle section is 0 ° C ~-5°C, the end 20cm is controlled at -5°C~-10°C, the drop distance (the distance from the dri...

Embodiment 4

[0059] prescription

[0060] Musk 7500mg, borneol 1000mg, turmeric volatile oil 1.5ml, turmeric total curcumin 250mg, gardenia total glycosides 300mg, polyoxyethylene monostearate 800mg, PEG20050mg, PEG6000 1730mg

[0061] preparation

[0062] In a closed device with a cooling cycle heating and heat preservation system, after polyethylene glycol and polyoxyethylene monostearate are heated and melted, add gardenia total glycosides, curcumin, turmeric volatile oil, and musk paste as claimed in claim 2 borneol powder, the advanced high-shear homogenization technology is used to forcibly disperse the components evenly, and the dripping system is kept at 80-90°C. 40-80 drops / min, the cooling liquid is liquid paraffin, using gradient cooling, the uppermost 15 cm to 20 cm is controlled at 0 ° C to 5 ° C, the middle section is 0 ° C to -5 ° C, and the end 20 cm is controlled at -5 ℃~-15℃, drop distance (distance from dripper to coolant page is 5-7 cm), average pill weight 25-30mg, w...

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PUM

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Abstract

The present invention relates to dispersed solid medicine composition, named as Xingnaojing, for treating infantile externally caused fever heat, infantile viral encephalitis fever heat, infantile supurative tonsillitis, senile cerebral vascular dementia and cerebral apoplexy in recovering stage. The solid medicine composition consists of musk, borneol, volatile curcuma root oil, total curcuma root curcumin and total cape jasmine glycoside, and is prepared into dripping pill, suppository, capsule, tablet, granule or other forms. The preparation process has separate extraction of the active components curcumin and total cape jasmine glycoside, high shearing technology and sealed circular apparatus for well maintenance of active components and quantitative indexes for the control of active components so as to ensure the stable quality and curative effect of the product.

Description

technical field [0001] The invention relates to a pharmaceutical composition of Xingnaojing solid dispersion and its preparation, and at the same time, the invention also relates to a preparation method of the pharmaceutical composition of Xingnaojing solid dispersion, which belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] Xinnaojing Injection is one of the commonly used Chinese patent medicines for clinical first aid determined by the Ministry of Health. Intravenous injections have achieved satisfactory results in the treatment of acute children with upper respiratory tract infection, high fever, viral encephalitis, children with suppurative tonsillitis, senile cerebrovascular dementia, and cerebral apoplexy, but the injections are inconvenient to use and may easily lead to allergies Response, and when the patient is unconscious, it can be administered through buccal or oral administration routes, and satisfactory curative effect ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/744A61K35/55A61K31/045A61K9/00A61K9/02A61K9/16A61K9/20A61K9/48A61P29/00A61P11/04A61P25/28A61P9/10
Inventor 托新权魏玉平
Owner 托新权
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