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Angelica and south date soft capsule and preparation method thereof

The technology of soft capsule and angelica is applied in the field of angelica nanzao soft capsule and its preparation, which can solve problems such as unfavorable taking of diabetic patients, stability of preparation quality, adverse effects of long-term storage, reduction of effective components, etc., and achieves the production process. Improve rationality, quality and efficacy assurance, and the effect of reducing dosage

Inactive Publication Date: 2009-04-01
CHONGQING PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the addition of a large amount of sucrose, the dosage is large, 10-20 grams each time, and it is inconvenient to take, especially unfavorable for diabetics.
The volatile oil in angelica has analgesic effect. According to the traditional preparation method and dosage form, the volatile oil components are not collected and dissipated, and the effective components are reduced, which affects its analgesic effect and curative effect
In addition, the extracts of angelica, jujube and Polygonum multiflorum have strong hygroscopicity, which has a major adverse effect on the quality stability and long-term storage of the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Angelica, jujube, and Polygonum multiflorum are fed according to the best formula.

[0042] 1. Take 1500 grams of Angelica sinensis, crush it into coarse powder, add 10 times the amount of water to decoct for 6 hours, and distill and collect volatile oil at the same time. After that, filter the decoction, and the filtrate is 60 0 C~90 0 Concentrate under reduced pressure at C to the medicinal material: when the concentrated solution = 1:1 (w / w), add an equal amount of ethanol to precipitate, filter, and obtain the filtrate for later use; add 8 times the amount of 70% ethanol to the dregs, reflux for 2 hours, and filter The dregs were added with 6 times the amount of 70% ethanol, refluxed for 1 hour, and filtered to obtain the filtrate. Each filtrate was combined, 60 0 C~90 0 C recovers ethanol under reduced pressure, concentrates into a thick paste for subsequent use.

[0043] 2. Take 700 grams of Chinese jujube and 175 grams of Polygonum multiflorum crushed into co...

Embodiment 2

[0047] Angelica, jujube, and Polygonum multiflorum are selected according to the best formula.

[0048] 1. Take 1500 grams of Angelica sinensis, crush it into a coarse powder, add 8 times the amount of 70% ethanol, soak it twice at room temperature for 24 hours each time, combine the soaking liquid, filter, and concentrate the filtrate into a thick paste.

[0049]2. Take 700 grams of Chinese jujube and 175 grams of Polygonum multiflorum crushed into coarse powder, add 10 times the amount of water to decoct for 2 hours, and filter to obtain the filtrate; add 8 times the amount of water to the dregs and decoct for 2 hours, filter, and use the filtrate twice Combined and concentrated under reduced pressure until medicinal material: concentrated solution = 1:1 (w / w), add an equal amount of ethanol to precipitate, filter, and the filtrate is at 60 0 C~90 0 C decompression reclaims ethanol, concentrates into thick paste (50 0 C, 1.20±0.5 g / ml) for later use.

[0050] Combine the ...

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PUM

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Abstract

The invention relates to an angelica and south date soft capsule and preparation method, wherein the capsule is prepared from (by weight ratio) Chinese angelica root 1200-1800g, Chinese date 560-840g and fleece-flower root 140-210g through mixing with vegetable oil and suspension adjuvant, and pressing into soft capsules.

Description

Technical field: [0001] The invention relates to a medicine and a preparation method thereof, in particular to an angelica nanzao soft capsule and a preparation method thereof. Background technique: [0002] Danggui Nanzao Granules is a variety of traditional Chinese medicine preparations recorded in the "Drug Standards of the Ministry of Health of the People's Republic of China", and the number is WS 3 -2314-97. [0003] Danggui Nanzao Granule is a commonly used medicine in gynecology, which has the effects of nourishing blood, promoting blood circulation, regulating menstruation and relieving pain. For blood deficiency, irregular menstruation, dysmenorrhea, headache, vomiting, insomnia, hypochondriac pain and habitual constipation caused by menstrual syndrome. [0004] For a long time, this prescription has always been in the form of granules. The traditional preparation method of this prescription is: soaking Angelica sinensis twice with 70% ethanol for 24 hours each ti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61K36/704A61K36/232A61K9/48A61P15/00
Inventor 唐文彦文慧英
Owner CHONGQING PHARMA RES INST
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