Isoliquirtigenin pessary for treating chronic cervicitis and method of preparing the same

A technology of chronic cervicitis and isoliquiritigenin, applied in the directions of suppository delivery, sexual diseases, drug combination, etc., can solve the problems of inconvenient daily life of patients, affecting adverse reactions, long healing time, etc., achieving no sequelae, good effect, and production. The effect of simple and easy process

Inactive Publication Date: 2010-07-21
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, various physical treatments are often used clinically, such as freezing, electric ironing, laser, infrared rays, etc., to destroy the columnar epithelium on the erosive surface of the cervix, make it necrotic and fall off, and be covered by new squamous epithelium, but there are postoperative bleeding and infection. , long healing time, the possibility of infertility caused by cervical stenosis, and many adverse reactions to vaginal delivery, and it also brings a lot of inconvenience to the daily life of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] Embodiments of the present invention will be described below, but the content of the present invention is not limited thereto at all.

[0029]

Isoliquiritigenin

matrix

stabilizer

buffer

β-cyclodextrin

Example 1

0.02％

90％

Sucrose 6%

Phosphate 3.48%

Beta-Cyclodextrin 0.5%

Example 2

0.04％

92％

Glucose 2.16%

Citrate 4%

Beta-cyclodextrin 1.8%

[0030]

Isoliquiritigenin

matrix

stabilizer

buffer

β-cyclodextrin

Example 3

0.08％

88％

Trehalose 8%

Acetate 3.07%

Beta-Cyclodextrin 0.85%

Example 4

0.10％

94％

Glucose 3%

Citric acid 2.36%

Beta-cyclodextrin 0.54%

Example 5

0.30％

91％

Lactose 7%

Glutaric acid 1.14%

Beta-cyclodextrin 0.56%

Example 6

0.90％

91％

Mannitol 4.18%

Citric acid 2.1%

Beta-cyclodextrin 1.82%

Example 7

...

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PUM

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Abstract

The invention discloses an isoliquiritigenin vaginal suppository used to treat chronic cervicitis and the preparation method. Isoliquiritigenin is used as an effective component to prepare vaginal suppository. The vaginal suppository contains isoliquirtigenin, medium, stabilizer, buffer, Beta-cyclodextrin, etc, which are proportioned according to a certain proportion. The formula of the inventionis reasonable, the use is convenient, and the drug combination prepared in the method has good effects of anti-inflammation, analgesia, anti-ulcer and promoting cervical epithelium restoration. And the preparation method of vaginal suppository has the advantages of simple operation, good efficacy and low side effects, etc.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to an isoliquiritigenin vaginal suppository for treating chronic cervicitis, and also relates to a preparation method of the isoliquiritigenin vaginal suppository. Background technique [0002] Chronic cervicitis (cervical erosion) is a chronic inflammatory injury disease of the cervix. There are many pathogenic factors, including viral and bacterial infections, chemical stimulation and mechanical damage. Cervical erosion can be true erosion, pseudo erosion. In chronic cervicitis, the process of cervical erosion and cervical healing is repeated, making chronic cervicitis a kind of refractory inflammation, and its mechanism is still unclear. At present, various physical treatments are often used clinically, such as freezing, electric ironing, laser, infrared rays, etc., to destroy the columnar epithelium on the erosive surface of the cervix, make it necrotic and fall off, and be covered by ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61K9/02A61K47/40A61K47/42A61P15/00
Inventor 杨静周倩朱玲新周茜余伟乐江陈刚刘洋
Owner WUHAN UNIV
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