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Medicine for treating cardiocerebral vascular disease and preparing method thereof

A technology for treating cardiovascular and cerebrovascular diseases and drugs, which can be applied to cardiovascular system diseases, drug combinations, and medical formulas, etc., and can solve the problem of only focusing on the collection of Sanqi, wasting medicinal plant resources, and insufficient development and utilization of the stems and leaves of Panax notoginseng And other issues

Inactive Publication Date: 2009-04-08
YUNNAN INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main production area of ​​Panax notoginseng is in Wenshan, Yunnan, and there are thousands of tons of Panax notoginseng stems and leaves every year. However, drug farmers generally only pay attention to the collection of Panax notoginseng, and neglect the stems and leaves of Panax notoginseng. valuable medicinal plant resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Get weight percent as 35% ginsenoside Rb 3 , 22% ginsenoside Rc, and the rest of the pharmaceutical excipients are prepared into capsules according to the conventional capsule manufacturing process.

[0032] The ginsenoside Rb 3 , Ginsenoside Rc is prepared by the following process:

[0033] Grind the stems and leaves of Panax notoginseng, reflux or cold soak them with 50-70% ethanol for 2-3 times, each time for 1-3 hours, filter, take the filtrate and concentrate it into an extract, add 2 times the weight of water, and precipitate Chlorophyll, filtered, put the filtrate on a 101 macroporous adsorption resin column, washed with water until colorless, eluted with ethanol gradient, collected 50-70% ethanol eluate, decolorized on a neutral alumina column, concentrated to no ethanol, added 2 Extract with twice the amount of n-butanol, decolorize with activated carbon whose weight is 2% of the n-butanol extract, concentrate and recover n-butanol, add acetone to crystallize...

Embodiment 2

[0035] Take the percentage by weight as 2% ginsenoside Rb 3 , 1% ginsenoside Rc, and the rest of the pharmaceutical excipients, according to the conventional granule manufacturing process to prepare granules.

[0036] The ginsenoside Rb 3 , Ginsenoside Rc is prepared by the above process.

Embodiment 3

[0038] Take weight percent as 30% ginsenoside Rb 3 , 20% Ginsenoside Rc, 8% Ginsenoside Rb 1 , the rest of the pharmaceutical excipients are made into tablets according to the conventional tablet manufacturing process.

[0039] The ginsenoside Rb 3 , Ginsenoside Rc, Ginsenoside Rb 1 Commercially available.

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PUM

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Abstract

The present invention relates to a kind of medicine prepared with effective components extracted from natural plant medicine materials and for treating cardiac and cerebral vascular diseases and its preparation process. The medicine consists of gensenoside Rb3 in 1-60 wt% and gensenoside Rc in 1-40 wt%, as well as medicinal supplementary material. The preparation process includes crushing and ethanol extracting ginseng stem and leaf to obtain extractum; adding water to deposit chlorophyll, filtering, and water washing in macroporous resin column to no color; gradient elution with ethanol to gather eluent, decolorizing in alumina column, and concentrating to no ethanol; extraction through adding acetone to crystallize and gathering crystal product; and adding medicine supplementary material.

Description

technical field [0001] The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases made from effective medicinal ingredients extracted from natural plant medicinal materials and a preparation method thereof. Background technique [0002] The stems and leaves of Panax notoginseng are the stems and leaves of the Araliaceae plant Panax notoginseng (Burk.) F.H.Chen. The main production area of ​​Panax notoginseng is in Wenshan, Yunnan, and there are thousands of tons of Panax notoginseng stems and leaves every year. However, drug farmers generally only pay attention to the collection of Panax notoginseng, and neglect the stems and leaves of Panax notoginseng. valuable medicinal plant resources. In recent years, scholars at home and abroad have conducted extensive research on Panax notoginseng, and found that the stems and leaves of Panax notoginseng contain a large amount of protopanaxadiol saponins, mainly ginsenoside Rb 1 , Rb 2 , Rb 3 , Rc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P9/10
Inventor 王作祥杨和金包广雷
Owner YUNNAN INST OF MATERIA MEDICA
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