Method and apparatus for enhanced nano-spectroscopic scanning

A nano-lens technology, applied in the field of nano-spectroscopy, which can solve the problem of not revealing or proposing, not proposing parallel readout of multiple samples, etc.

Inactive Publication Date: 2009-04-08
VP HLDG LLC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This patent does not disclose or suggest a method for using electromagnetic gap modes to increase the spectral resolution that can be used to analyze a single chemical structure, such as a DNA base, nor does it suggest a system capable of parallel readout of multiple samples, such as stretched DNA strings

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  • Method and apparatus for enhanced nano-spectroscopic scanning

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Embodiment Construction

[0037] I. Definition

[0038] The following terms have the following meanings, unless otherwise stated, "plasmon resonance metal" includes any metal, such as gold, silver or aluminum, which can support surface electromagnetic modes - surface plasmon polarization (SPP), i.e. photons and plasmons Coupling modes of bulk oscillators.

[0039] A "chemical group" in a sample may include a subunit or part of a subunit in a polymer, such as a nucleic acid group, or a chemically substituted molecular group, such as a hydroxyl, amine, alkyl, acid or aldehyde group. These chemical groups are characterized by characteristic enhanced Raman spectral signatures or characteristics.

[0040] "Gap mode" refers to electromagnetic conventional modes or electromagnetic eigenmodes that are placed near a metal surface by an external electromagnetic field located in the gap between two or more plasmon resonant particles (less than 40nm), especially when the plasmon resonance is excited on the meta...

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Abstract

Apparatus and method for examining the identity of chemical groups in a sample are disclosed. The apparatus has a substrate having a plasmon resonant surface on which the sample is supported, a source of a beam of light, and a lens assembly having a tip region and a nanolens composed of one or more plasmon resonance particles (PRPs) on the tip region. The PRPs are arranged to produce near-field electromagnetic gap modes in a space between the nanolens and a confronting detection region on the substrate surface when the gap between the nanolens and substrate is 30 nm or less. A focusing mechanism in the apparatus operates to move the lens assembly toward and away from the substrate surface, with a gap of less than 30 nm, to produce electromagnetic gap modes that enhance the Raman spectroscopy signals produced by the sample in the detection region. The apparatus and method are useful, for example, in identifying successive bases in a single DNA strand, for direct DNA sequencing.

Description

technical field [0001] The invention relates to the field of nanometer-spectral scanning, in particular to a method and device capable of performing spectral identification on single molecules or single chemical groups attached to substrates. Background technique [0002] The following references are provided as background in part to the present invention and / or to provide ways in which certain aspects of the invention might be used. These materials are incorporated herein by reference. [0003] G. R. Brewer, Electron-Beam Technology in Microelectronic Fabrication, Academic Press, NY, (1980). [0004] "The evolution of Dip-Pen Nanolithography" by David Ginger et al., Angew. Chem. Int. Ed., v.43, p.30-45, (2004). [0005] S. Hayashi, "Spectroscophy of Gap Modes in Meta Paricle-Surface Systems", Tpoics Appl Phys 81: 71-95 (2001). [0006] "Ultrasensitive Chemical Analyzes by Raman Spectroscophy" by I-K. Kneipp et al., Chem. Rev., 1999, Vol.99, p.2957-2975, see p.271. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01J3/44G01N21/65G01Q60/18
CPCG01N21/658G02B5/204B82Y20/00G01N2021/656B82Y15/00G01J3/44
Inventor V·波波尼恩
Owner VP HLDG LLC
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