IgY production for preventing oral cavity disease and tooth paste based on it

Abstract

The invention relates to a preparation method of egg yolk immunoglobulin for preventing and curing mouth diseases, and a safe toothpaste with the egg yolk immunoglobulin as main material. When preparing the IgY, according to a main pathogen causing the decayed tooth, periodontal disease and halitosis, types of main pathogenic bacteria are cultured in a conventional method. A complex antigen is made with the cultured strains and injected to laying poultries (including hens, ducks, and turkeys and so on). And then needed IgY is made by the yolks of immune eggs laid by the poultries. When making the toothpaste with the IgY, the toothpaste comprises 0.01-10.0% egg yolk immunoglobulin, vesicant and other components. The IgY activity is maintained and the effect is strengthened by adopting gentle vesicant, film microcapsule, sandwich type or interlayer type toothpaste tube and oral mucosa adsorbent. The prepared toothpaste without harmful chemicals has great effect on preventing and curing decayed tooth, periodontal disease and halitosis, and can be swallowed.

Description

technical field [0001] The invention relates to a preparation method of IgY (Immunoglobulin of Yolk, egg yolk immunoglobulin) for preventing and treating various oral diseases, and an immune safe toothpaste which uses the IgY as a main raw material and is used for preventing and treating oral diseases. Background technique [0002] Although the formulations of various toothpastes are different, they usually contain sodium dodecyl sulfonate (SDS), sodium lauryl sarcosinate, lauryl glycol amide, sodium polyacrylate, etc. Chemical substances that can cause damage to human health should be avoided as much as possible when brushing teeth with these toothpastes. However, studies have shown that when adults brush their teeth, 15-20% of each dose will be swallowed by mistake; and when children brush their teeth, about 40% of each dose will be swallowed by mistake. Long-term use of toothpaste containing the above-mentioned harmful substances is bound to endanger health, especially f...

AI Technical Summary

Problems solved by technology

[0005] (2) According to the follow-up observation of children using fluoride toothpaste for 2 consecutive months, due to the great difference in the amount of toothpaste used by children and the frequent occurrence of accidental swallowing of toothpaste, some children's intake of fluoride is higher than the standard for fluoride supply fluorine, which is very harmful to the health of children (especially children living in high-fluorine areas and fluorine-friendly areas);

[0006] (3) Long-term application of fluoride will cause cariogenic bacteria to mutate and produce fluorine-resistant strains. This strain is not only resistant to fluoride, but also has stronger cariogenic ability, resulting in aggravated dental caries

[0007] In addition, most of the popular toothpastes on the market that have the effect of anti-periodontal disease or eliminating bad breath contain broad-spectrum chemical bactericides. Since these chemical bactericides will also kill the beneficial bacteria in the oral cavity, it is bound to damage the oral cavity. The ecological balance of flora in

Just brushing your teeth will be effective for a short time, but after a few hours, the pathogenic bacteria will multiply again; and regular use of this kind of toothpaste containing broad-spectrum chemical fungicides will make the pathogenic bacteria in the oral cavity develop drug resistance, which will last for a long time , the condition worsened

[0008] In order to prepare IgY, one of the methods in the prior art is to use organic solvents, such as caprylic acid, alcohol, acetone, chloroform, etc., this method has a certain impact on the activity of IgY, and there will be chemical substance residues, which will affect the environment and health; method The second is to prepare by precipitation method, such as polyethylene glycol, dextran sulfate, etc., the disadvantage is that the yield is low, and there is also the problem of organic chemical residues; the third method is the water dilution method. The advantages are simple process, high yield, low cost, especially without any chemical pollution, and good safety, but there are shortcomings of incomplete lipid removal

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