Medicine composition containing cefateram cyclodextrin capsule and its preparing method

Abstract

A composite medicine with high solubility, stability and activity and low hemolytic irritation contains cefteram ester and the pharmacologically acceptable dextrin chosen from beta-cyclodextrin and its derivatives. Its preparing process is also disclosed.

Description

Pharmaceutical composition containing cefdteren pivoxil cyclodextrin inclusion complex and preparation method thereof technical field The invention relates to a pharmaceutical composition containing cephalosporin antibiotic cyclodextrin inclusion complex and a preparation method thereof. Background technique Cefdteren pivoxil, English name: Cefteram Pivoxil, synonym: Cefdteren neopentyl pivoxil, trade name: Tomiron, chemical name (+)-(6R, 7R)-7-[(z)-2 -(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-[(5-methyl-2H-tetrazol-2-yl)-methyl]-8-oxo -5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid pivaloyloxymethyl ester, molecular formula C22H27N9O7S2, molecular weight 593.63. This product is a solid insoluble in water, melting point: about 110°C, good photothermal stability in solid state, unstable in solution, and decomposes rapidly when encountering acid and alkali. This product is the third-generation oral cephalosporin, which is the prodrug of cefdteren modified by...

AI Technical Summary

Problems solved by technology

Therefore, the use of cyclodextrins to improve the pharmaceutical suitability of cefditoren pivoxil is difficult and unpredictable

Images