Medicine composition containing cefateram cyclodextrin capsule and its preparing method
A technology of cyclodextrin inclusion compound and cefditoren axetil, which is applied in the field of pharmaceutical composition containing cefditoren axetil cyclodextrin inclusion compound and its preparation, and can solve problems such as difficulty in the pharmaceutical adaptability of cefditoren axetil , to achieve the effect of improving oral bioavailability, easy dissolution and good stability
Inactive Publication Date: 2010-11-24
海南和德通医药科技信息咨询有限公司
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Problems solved by technology
Therefore, the use of cyclodextrins to improve the pharmaceutical suitability of cefditoren pivoxil is difficult and unpredictable
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Abstract
A composite medicine with high solubility, stability and activity and low hemolytic irritation contains cefteram ester and the pharmacologically acceptable dextrin chosen from beta-cyclodextrin and its derivatives. Its preparing process is also disclosed.
Description
Pharmaceutical composition containing cefdteren pivoxil cyclodextrin inclusion complex and preparation method thereof technical field The invention relates to a pharmaceutical composition containing cephalosporin antibiotic cyclodextrin inclusion complex and a preparation method thereof. Background technique Cefdteren pivoxil, English name: Cefteram Pivoxil, synonym: Cefdteren neopentyl pivoxil, trade name: Tomiron, chemical name (+)-(6R, 7R)-7-[(z)-2 -(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-[(5-methyl-2H-tetrazol-2-yl)-methyl]-8-oxo -5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid pivaloyloxymethyl ester, molecular formula C22H27N9O7S2, molecular weight 593.63. This product is a solid insoluble in water, melting point: about 110°C, good photothermal stability in solid state, unstable in solution, and decomposes rapidly when encountering acid and alkali. This product is the third-generation oral cephalosporin, which is the prodrug of cefdteren modified by...
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IPC IPC(8): A61K31/546A61K47/40A61P31/04
Inventor 任勇高剑锋孙海松韩彬彬吴玲孙晓东
Owner 海南和德通医药科技信息咨询有限公司
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