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Plant extract with hypotensive effect and its preparing process and use

A plant extract and extract technology, applied in the direction of medical preparations containing active ingredients, plant raw materials, plant/algae/fungus/moss components, etc., can solve the problem of no antihypertensive effect, achieve good drug effect, The effect of good blood pressure application effect

Inactive Publication Date: 2007-08-08
欧阳冬生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the lignans and iridoids of Eucommia ulmoides are extracted separately, whether they all have a good antihypertensive effect or do not have an antihypertensive effect, there is no relevant research and explanation in the prior art

Method used

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  • Plant extract with hypotensive effect and its preparing process and use
  • Plant extract with hypotensive effect and its preparing process and use
  • Plant extract with hypotensive effect and its preparing process and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Take 2Kg of bark of Eucommia ulmoides (with the outer skin removed), extract twice with 8L of 65% ethanol under reflux, each time for 1h, filter, combine the two extracts and concentrate to 800ml. Mix and load the sample with D101 macroporous resin (column volume of macroporous resin is 3 L), wash with water for 3 times of column volume, continue to wash with 1% ammonia water for 3 times of column volume, and then wash with water until neutral. Elute with 20% ethanol for 2 column volumes and 45% ethanol for 2.5 column volumes. The 45% ethanol eluate was concentrated to 600ml. The eluate was concentrated and dried to a powder. Using pinoresinol diglucoside as a control, the content of lignans in the extract was 85% as detected by ultraviolet light, and the content of pinoresinol diglucoside as detected by HPLC was 12.5%.

Embodiment 2

[0088] Take 20kg of Eucommia ulmoides bark (with the outer skin removed), add 8 times and 6 times the amount of 80% ethanol successively for reflux extraction for 1.5h and 1h, combine the extracts, filter, concentrate the medicinal solution to about 20L, and pass through the HPD100 macroporous adsorption resin column, Wash 1 times the column volume with water, collect the washing solution, concentrate; elute with 20% ethanol, concentrate; then elute with 50% ethanol for 3 times the column volume, collect the 50% ethanol eluate, concentrate, freeze-dry to obtain the extract material powder. Using pinoresinol diglucoside as a control, the content of lignans in the extract was 69% as detected by ultraviolet light, and the content of pinoresinol diglucoside as detected by HPLC was 7.5%.

Embodiment 3

[0090]After the bark of Eucommia ulmoides was crushed, 9 L of 60% ethanol was added to reflux for extraction for 1 h, filtered, and the filter residue was extracted with 7 L of 60% ethanol for 1 h, filtered, the two extracts were combined, and concentrated until there was no alcohol smell to obtain a concentrated solution of about 3 L. The concentrated solution was passed through the AB-8 macroporous adsorption resin column, firstly eluted with 5L of water, then 7L of 60% ethanol, collected the 60% ethanol eluate, concentrated to 150ml, slowly added to 450ml of water, filtered, concentrated, A dry solid powder was obtained. Using pinoresinol diglucoside as a control, the content of lignans in the extract was 51% by ultraviolet detection, and 3.5% by HPLC.

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Abstract

The invention relates to a method for preparing the vegetable extractive with blood pressure reduction function, which contains lignans at 30-90mass% of total weight as the effective component, while said extractive can be used to prepare the food, drug or health product used to prevent and treat high blood pressure and relative complication.

Description

technical field [0001] The invention relates to a plant extract and its preparation method and application. The extract is extracted and separated from Eucommia ulmoides, a plant of Eucommia genus Eucommia, and is used for treating or preventing hypertension and its complications. Background technique [0002] Eucommia ulmoides (Duzhong, Eucommia ulmoides Oliv) belongs to Eucommia ulmoides. It is a rare and precious medicinal material unique to China. Its skin is used as medicine. It has the effects of nourishing liver and kidney, strengthening bones and bones, and anti-abortion. It can be used clinically for the treatment of hypertension. People have been expecting to find the main antihypertensive substances in Eucommia in order to develop new drugs with better curative effect and fewer adverse reactions. So far, more than 70 kinds of monomers have been isolated and extracted from Eucommia ulmoides, mainly including lignans, phenylpropanoids, iridoids, flavonoids, etc. Li...

Claims

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Application Information

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IPC IPC(8): A61K36/46A61K9/00A61P9/12A61K129/00
Inventor 欧阳冬生周应军吴卫华阳国平严谨罗丽芳吴孔松姜德建杨天伦李元建
Owner 欧阳冬生
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