Supercritical extraction process of water extracted and alcohol deposited safflower residue

A water extraction, alcohol precipitation, and supercritical technology, which is used in pharmaceutical formulations, medical preparations containing active ingredients, and plant raw materials to achieve the effect of increasing comprehensive economic value.

Inactive Publication Date: 2007-08-22
SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no method to use supercritical extraction technology to further efficiently utilize the effective components of the drug in the water-extracted alcohol-precipitated drug residue

Method used

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  • Supercritical extraction process of water extracted and alcohol deposited safflower residue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Take 100 grams of safflower residue extracted by water and alcohol, grind to 0.15mm-1mm, dry at a low temperature below 60°C, place it in the extraction tank 5 and seal it. Open the gas tank 1, the carbon dioxide reaches the extraction tank 5 through the condensation tank 2 and the high-pressure pump 3, and conducts the first extraction at 8MPa and 60°C. The extract enters the primary separation tank 7, and performs primary separation at 8MPa and 12°C to obtain safflower wax. Carbon dioxide continues to enter the secondary separation tank 8, 6MPa, 45 ℃ secondary separation of safflower volatile oil. After separation, the clean carbon dioxide fluid is condensed by the condenser and recycled in the device. After 2 hours of dynamic operation, 1.7 grams of safflower volatile oil and 0.06 g of vegetable wax were obtained from the separation tank. Increase the pressure to 25mpa, and carry out the second extraction of the raffinate of the safflower water-extracted...

Embodiment 2

[0018] Example 2: Take 100 grams of safflower water extraction and alcohol precipitation residue, grind to 0.15mm-1mm, dry at a low temperature below 60°C, put it in the extraction tank 5 and seal it. Open the gas tank 1, the carbon dioxide reaches the extraction tank 5 through the condensation tank 2 and the high-pressure pump 3, and conducts the first extraction at 10MPa and 45°C. The extract enters the primary separation tank 7, and performs primary separation at 9MPa and 8°C to obtain safflower wax. The carbon dioxide continues to enter the secondary separation tank 8, and the safflower volatile oil is separated in the secondary separation at 1MPa and 20°C. After separation, the clean carbon dioxide fluid is condensed by the condenser and recycled in the device. After 6 hours of dynamic operation, 2.4 grams of safflower volatile oil and 0.08 g of vegetable wax were obtained from the separation tank. Increase the pressure to 28mpa, and carry out the second extraction on t...

Embodiment 3

[0019] Example 3: Take 100 grams of safflower residue extracted by water and alcohol, crush to 0.15mm-1mm, dry at a low temperature below 60°C, put it in the extraction tank 5 and seal it. Open the gas tank 1, the carbon dioxide reaches the extraction tank 5 through the condensation tank 2 and the high-pressure pump 3, and conducts the first extraction at 12MPa and 35°C. The extract enters the primary separation tank 7, and performs primary separation at 10MPa and 12°C to obtain safflower wax. Carbon dioxide continues to enter the secondary separation tank 8, 4MPa, 30 ℃ secondary separation of safflower volatile oil. After separation, the clean carbon dioxide fluid is condensed by the condenser and recycled in the device. After 6 hours of dynamic operation, 3.5 grams of safflower volatile oil and 0.08 g of vegetable wax were obtained from the separation tank. Increase the pressure to 32mpa, and carry out the second extraction on the safflower water-extracted alcohol-precipit...

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Abstract

The supercritical extraction process of water extracted and alcohol deposited safflower residue includes low temperature drying the safflower residue at 60 deg.c; the first supercritical CO2 extracting at 8-12 MPa and 35-60 deg.c, the first separation at 8-10 MPa and 0-12 deg.c to obtain vegetable wax and the second separation at 1-6 MPa and 20-45 deg.c to obtain volatile safflower oil; the second extracting at 22-32 MPa and 35-60 deg.c, and separation at 2-6 MPa and 20-40 deg.c to obtain macromolecular non-polar matter. The present invention utilizes the non-polar matter in safflower effectively, realizes the initial separation of different kinds of matter and raises the comprehensive economic value of safflower processing.

Description

technical field [0001] The invention belongs to the use of supercritical CO 2 The invention discloses a method for extracting volatile oil and macromolecular non-polar substances contained in safflower water-extracted and alcohol-precipitated medicinal residues. Background technique [0002] Safflower is the tubular flower of Compositae—annual herbaceous plant safflower (Carthamus tinctorius L.), which is planted in a large area in Xinjiang, Sichuan and other places in my country, and is rich in resources. Studies have shown that safflower preparations such as safflower injection or oral liquid can be used to treat uterine congestion, cardiovascular, thrombosis and other diseases, as well as analgesic and anti-inflammatory agents, and have been widely used clinically. [0003] In the process of producing safflower injection or oral liquid, the process of water extraction and alcohol precipitation is mainly used, resulting in a large amount of drug residues. On the one hand...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286
Inventor 毕继诚韩小金张荣王江泉
Owner SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
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