Supersonic microvesicle target positioning controlled-release/gene device and target transferring method

Abstract

An ultrasonic microvesicle apparatus for directional location and release control of medicine or gene is composed of an ultrasonic triggering-therapeutic unit, a driver unit, an ultrasonic monitor unit, and a computer control unit consisting of host, display, image acquisition card, etc. A method for combining the microvesicle contrast medium with medicine or gene and using ultrasonic wave for target transfer is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and in particular relates to an ultrasonic microbubble targeted positioning and controlled release drug / gene and effect evaluation device and a method for combining microbubble contrast agent and drug / gene with ultrasound to realize targeted transfer. Background technique [0002] Drug / gene delivery is a key technology to fully exert the biological effects of the drug / gene itself. At present, the common drug / gene delivery carriers are viral and non-viral, such as direct drug / gene injection, liposome-mediated, receptor-mediated, particle bombardment technology, electroporation, etc. [0003] Although the existing viral vectors in gene transfer technology have a high gene transfection rate, there are problems such as safety and the body's immune response to the virus; non-viral vectors such as plasmids are safe, but the transfection rate is low. Proteins, peptides, and chemotherape...

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Problems solved by technology

[0003]In the gene transfer technology, although the existing virus carrier has a high gene transfection rate, there are problems such as safety and the body's immune response to the virus; and other non-viral vectors, although safe, but the transfection rate is low

Proteins, peptides, and chemotherapeutic drugs, like gene drugs, have the disadvantages of poor targeting by intravenous injection, and the amount of drugs / genes reaching specific tissues is small and inefficient; local injection of drugs / genes has a limited scope of application and Invasive and other issues

At present, there are many unresolved problems in the field of drug / gene delivery technology, especially the lack of safe, effective, tissue-specific and targeted drug / gene delivery systems

[0004]As a new drug / gene delivery tool, microbubble contrast agent combines specific drugs / genes with microbubble contrast agent and injects them through peripheral blood vessels. Ultrasound is used to destroy gene-carrying microbubbles, so that microbubbles can be released in specific tissues. This new drug / gene delivery method has the advantages of non-invasive, efficient, easy to operate, good targeting, safety and good repeatability. However, there is still a lack of special devices for ultrasound targeted positioning and controlled release of drugs / genes, especially devices that integrate positioning, monitoring, diagnosis and treatment

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