Unlock instant, AI-driven research and patent intelligence for your innovation.

Hydrochlorothiazide grain and sugar-coat producing technique of compound luobuma tablets

A technology of hydrochlorothiazide and apocynum, applied in the field of pharmaceuticals, can solve problems such as unstable content of compound apocynum tablets I, and achieve the effect of stable quality

Inactive Publication Date: 2007-09-19
SHANGHAI SINE WANXIANG PHARMA
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to overcome above-mentioned weak point, provide a kind of new technological method, to solve the content unstable problem of Compound Apocynum Tablets I in the storage period

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0037] prescription:

[0038] Hydrochlorothiazide 20g

[0039] Dextrin 20g

[0040] Lactose 60g

[0041] 50% ethanol 20g

[0042] a. Mix hydrochlorothiazide, dextrin, and lactose evenly, and grind them into powder with a 100-mesh pulverizer.

[0043] b. With 50% ethanol solution.

[0044] c. Mix the mixed powder in step a in a three-phase wet granulator for 3 minutes, add the solution in step b, and stir to make granules;

[0045] Step d.c The wet particles are dried in a boiling dryer, and the material temperature reaches 50-65°C, and then dried.

[0046] The dry granules in step e.d are sieved with a layered sieve to take particles between 30 and 80 mesh, and the particles that do not pass through 30 mesh are crushed by a crusher without a sieve plate, and then continue to be sieved with a layered sieve to take particles between 30 and 80 mesh, and repeat the above process;

[0047] f. Through 80-mesh fine powder, granulate again in a three-phase wet granulator with p...

example 2

[0049] prescription:

[0050] Hydrochlorothiazide 20g

[0051] Starch 70g

[0052] Hypromellose 8g

[0053] Starch (made into 12% pulp) 2g

[0054] a. Mix hydrochlorothiazide and starch evenly, and grind them into powder with a 100-mesh pulverizer.

[0055] b. 2g starch is made into 12% starch slurry.

[0056] c. Mix the mixed powder in step a in a three-phase wet granulator for 3 minutes, add the starch slurry in step b, and stir to form granules;

[0057] The operation method of d, e, f step is the same as example (1).

example 3

[0058] Example 3 (supplementary operation method)

[0059] prescription:

[0060] Hydrochlorothiazide 20g

[0061] Starch 38g

[0062] Sucrose powder 40g

[0063] Povidone 2g

[0064] 65% ethanol 15g

[0065] Example prescription (3) granulation method is the same as (1), only dextrin and lactose are replaced with starch and sucrose powder, 50% ethanol solution is changed to 65% ethanol, and polysaccharide is added in the mixed powder of c step Vitone acts as a binder.

[0066] Coating prescription:

[0067] Hydrochlorothiazide Granules (30~80) mesh 40.0Kg

[0068] Copovidone 6~10Kg (make into 5-15% aqueous solution)

[0069] Coating operation:

[0070] g. Put the hydrochlorothiazide granules in the boiling coating machine and turn on the machine to heat up.

[0071] h. Dissolving copovidone in water to prepare a 10% aqueous solution for subsequent use.

[0072] i. When the temperature of the granules in the boiling coating machine reaches 44°C, start to spray the l...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a granulating and coating process of hydrochlorothiazide in compound kendir leaves tablets I. By isolating and coating to the hydrochlorothiazide of the invention, contact with the other raw materials and accessories is blocked. The process of the invention can make the compound kendir leaves tablets I maintain content and quality stable in storage period, which are applicable to commercial process.

Description

Technical field: [0001] The invention belongs to the field of medicines, and in particular relates to a granulation and coating process of hydrochlorothiazide in compound apocynum tablets I. Background technique: [0002] Compound apocynum tablet I mainly consists of apocynum, wild chrysanthemum, Fangji dry extract and hydrochlorothiazide as active ingredients. When the detection of the active ingredient hydrochlorothiazide in the quality standard was changed from identification to quantitative detection, the quantitative detection of the reserved samples found that the content of hydrochlorothiazide decreased during the storage period, and continued to decline with the prolongation of the retention time. Failed. The application of differential analysis results showed that hydrochlorothiazide interacted with some raw materials and excipients in Compound Apocynum Tablets I, and the stability was poor, which seriously affected the quality of Compound Apocynum Tablets I. Inv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/549A61K9/20
Inventor 吴福荣
Owner SHANGHAI SINE WANXIANG PHARMA