Microemulsion and sub-micron emulsion process and compositions
A composition and submicron technology, applied in the field of microemulsion and submicron emulsion, can solve the problems of reducing the ease of microemulsion
Active Publication Date: 2011-06-22
STIEFEL RESEARCH AUSTRALIA PTY LTD
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
In the case of poorly soluble pharmaceutical actives, the need for additives such as propylene glycol that can aid in penetration is evident, but conversely, reduce the ease of preparation of microemulsions
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1A
[0151]
[0152] Cyclomethicone
[0153] potassium citrate
[0154] Examples 1 and 1A show a surfactant cetearyl ether-20: sorbitan monolaurate: cetyl alcohol ratio of 6.5:1.5:20 where propylene glycol is added to a single stage of the composition. in the water phase. The product is isolated for use, has very low redispersibility in the tank, and requires constant mixing in operation, which is expensive in large-scale production.
Embodiment 2
[0156]
[0157] the second part
[0158] Example 2 shows a surfactant ratio of cetearyl ether-20: sorbitan monolaurate: cetyl alcohol of 4.5:4.5:1.0.
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Abstract
A process for the preparation of an oil in water (O / W) microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient includes the steps of a) mixing a first part including an oil phase containing one or more lipophilic surfactants, and a second part including water and at least one hydrophilic surfactant to achieve homogeneity, b) heating the mix of step a) to a phase assembly temperature in the range of 40 - 99 DEG C with continuous mixing to obtain a microemulsion or sub-micron emulsion, c) allowing said microemulsion or sub-micron emulsion to cool, and d) adding a third part to said microemulsion or sub-micron emulsion at a temperature between 2 DEG C and said phase assembly temperature, the third part including at least one component selected from the group consisting of non-surfactant amphiphilic type compound, surfactant and water with the proviso that when the third part includes water, and also includes a non-surfactant amphiphilic type compound and / or surfactant.
Description
technical field [0001] The present invention relates to a method of formulating microemulsions and submicron emulsions for cosmetic and therapeutic applications in the field of dermatology. In particular, it relates to methods of formulating stable microemulsions and submicron emulsions comprising components known to be degradable in the physical state of the formulation. The present invention also relates to cosmetic and therapeutic microemulsion and submicron emulsion compositions resulting from these methods. The present invention includes cosmetic and therapeutic methods of treatment using microemulsions and submicron emulsions, as the use of compositions resulting from said formulations in appropriate treatments. Background technique [0002] The size of the particle is critical to its ability to cross the skin barrier and release the pharmaceutically active ingredient for the treatment of the local or systemic condition of the patient concerned. As the particles beco...
Claims
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IPC IPC(8): A61K9/107A61K9/10A61Q19/00B01F3/08B01F3/20B01F3/22A61P17/00B01F23/70B01F23/80
Inventor 马里亚·格拉齐耶拉·拉尔姆罗纳德·哈丁迈克尔·约翰斯顿普雷玛·维贾雅库马菲比·孙艾伯特·佐尔科·艾布拉姆
Owner STIEFEL RESEARCH AUSTRALIA PTY LTD