Fiber-modified adenoviral vectors for enhanced transduction of tumor cells

A tumor cell and adenovirus technology, applied in the field of adenovirus vectors, can solve the problem of low efficiency of primary tumor cells
CN101068933AInactive Publication Date: 2007-11-07细胞基因系统有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
细胞基因系统有限公司
Publication Date
2007-11-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

Adenoviral vectors which effectively transduce primary tumor cells are provided. The adenoviral vectors comprise a chimeric adenovirus fiber protein which includes at least a portion of a Subgroup C adenovirus fiber shaft and at least a portion of a Subgroup B adenovirus or serotype 37 adenovirus head, wherein the head region binds CD46.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of US Provisional Patent Application No. 60 / 604,009, filed August 25, 2004, which is incorporated herein by reference in its entirety. Technical field:

[0003] The present invention relates to adenoviral vectors comprising chimeric fibrin and exhibiting enhanced transduction of tumor cells, especially primary tumor cells, compared to non-chimeric adenoviral vectors. Background technique:

[0004] Gene therapy is used as a means of delivering exogenous nucleotide sequences to cells and is the basis for some of the most novel and promising disease-fighting tools. This approach is extremely useful in the treatment of not only cancer but many other diseases including cystic fibrosis, anemia, hemophilia, diabetes, Huntington's disease, AIDS, abnormally high serum cholesterol, certain immunodeficiencies, and many forms of cancer. big prospects. Gene therapy typically relies on delivery ...

Claims

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