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Medicinal composition for preventing tumor

A composition and anti-tumor technology applied in the field of medicine

Inactive Publication Date: 2007-11-21
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are no anti-tumor drugs prepared by using ginseng or total ginsenosides, Poria cocos or Poria cocos polysaccharides and Sophora flavescens or total alkaloids / Hedyotis diffusa or Hedyotis diffusa extracts to interact and form compatible prescriptions. see the report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0169] The preparation of embodiment 1 total ginseng saponins

[0170] Preparation process of total ginseng saponins:

[0171] Take the ginseng medicinal material, crush it into a coarse powder, add ethanol to reflux and extract twice, add 10 times the amount of ethanol each time, extract for 3 hours, combine the extracts, refrigerate, filter, recover the ethanol from the filtrate and concentrate to a thick paste, add water to an appropriate amount ( Make each 1ml equivalent to 1g of the original medicinal material), stir well, refrigerate, filter, add water-saturated n-butanol to the filtrate to extract 3 times, each time add 1 times the amount of water-saturated n-butanol, combine the n-butanol liquid, and evaporate to dryness in a water bath Then add appropriate amount of water to dissolve, add to the treated macroporous resin column, first elute with 2 to 3 times column volume of water, then 2 times column volume of 20% ethanol, discard the water washing solution and 20% ...

Embodiment 2

[0185] Embodiment 2 Preparation of Poria cocos polysaccharide

[0186] The preparation technology of Poria cocos polysaccharide:

[0187] Take Poria cocos medicinal material, crush it into coarse powder, add 4 to 6 times the amount of water, reflux extraction three times, the extraction time is 3 hours, 2 hours, 1 hour respectively, combine the three extracts, filter, and concentrate the filtrate under reduced pressure to relative When the density is 1.0-1.1, add ethanol until the alcohol content is 60%, let stand, refrigerate overnight, filter, collect the precipitate, add 2 times the amount of water to boil to dissolve, filter out the insoluble matter while it is hot, let the filtrate cool, add ethanol Make the alcohol content to 80%, refrigerate and stand for 24 hours, filter, and wash the precipitate repeatedly with 70% ethanol, acetone and ether for several times. Add 1 times the amount of water to dissolve, add 0.1% activated carbon to decolorize, filter with a 5000 ult...

Embodiment 3

[0197] Embodiment 3 preparation of total alkaloids of matrine

[0198] The preparation method of total alkaloids of matrine

[0199] Take Sophora flavescens, crush it into coarse powder, percolate with 0.2% hydrochloric acid until there is no alkaloid reaction, collect the percolation liquid, and pass it through the treated strong acid cationic resin. After the exchange, wash the resin with water to neutral ,dry. Alkaline the resin with concentrated ammonia water, put it into a Soxhlet extractor and extract it with chloroform continuously under reflux until there is no alkaloid reaction in the extract. The chloroform extract was dehydrated with anhydrous sodium sulfate, and the chloroform was recovered under reduced pressure to obtain a thick paste.

[0200] Identification experiment of total alkaloids of matrine

[0201] (1) Take about 10 mg of this product, add 10 ml of 1% hydrochloric acid solution to dissolve, filter, and divide the filtrate into three test tubes, add b...

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Abstract

The invention is concerned with the method of preparation of the compound medicine for anti-tumor, and it contents: ginseng, Tuckahoe, radix sophorae flavescentis and / or oldenlandia diffusa; or ginsenoside, Tuckahoe polysaccharide, radix sophorae flavescentis with total alkali and / or oldenlandia diffusa extract to make the kind of potion is acceptable for phamarcy.

Description

1. Technical field [0001] The present invention relates to an anti-tumor pharmaceutical composition mainly made of ginseng or total ginsenosides, Poria cocos or Poria cocos polysaccharide and Sophora flavescens or total alkaloids / Hedyotis diffusa or Hedyotis diffusa extract and its The preparation method belongs to the technical field of medicine. 2. Background technology [0002] Tumors, especially malignant tumors (cancers), are a class of diseases that seriously threaten human life and health, and the mortality rate is extremely high. According to statistical data, about 1 million cancer patients are newly discovered in my country every year, and cancer kills about 6 million people every year in the world, and puts 10 million people on the verge of death. It has become the number one killer of human beings. A tumor is a developing or mature normal cell in the human body. Under the long-term action of certain adverse factors, a certain cell group, a new organism formed by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P35/00
Inventor 黄振华
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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