Compounds and their use for treating somatic mutation-related diseases

A compound, hydrate technology, applied in the treatment or prevention of diseases related to mRNA nonsense mutation, inhibiting premature translation termination related to mRNA nonsense mutation, can solve the problem of no public application of clitocine, no report of development of clitocine analogs or Derivatives etc.
CN101076703AInactive Publication Date: 2007-11-21PTC THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
PTC THERAPEUTICS INC
Publication Date
2007-11-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
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Description

[0001] related application

[0002] This application claims priority and the benefit of US Application 60 / 617,653, filed October 13, 2004, and US Application 60 / 624,170, filed November 3, 2004, under 35 U.S.C. §119. US Application 60 / 624,170, filed November 3, 2004, is hereby incorporated by reference in its entirety. Pursuant to 35 U.S.C. §119, this application claims U.S. Application 60 / 617,655, filed October 13, 2004, U.S. Application 60 / 617,634, filed October 13, 2004, U.S. Application, filed October 13, 2004 60 / 617,633, priority and benefit of US Application 60 / 617,670, filed October 13, 2004, which are hereby incorporated by reference in their entirety. This application also incorporates by reference the entire contents of International Patent Applications filed on October 13, 2005, entitled "Compounds for Nonsense Suppression, and Method for Their Use" and Attorney Docket Nos. identified as 19025.040, 19025.041, 19025.043, and 19025.044. technical field

[0003] The p...

Claims

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