Unlock instant, AI-driven research and patent intelligence for your innovation.

Compound red sage root freezing-dried powder injection containing tanshinol and its preparation method

A technology of freeze-dried powder injection and compound salvia miltiorrhiza, applied in the field of medicine, can solve the problems of inconvenience to carry, slow onset of effect, large dosage and the like

Inactive Publication Date: 2011-11-30
TIANJIN TASLY ZHIJIAO PHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing Chinese patent medicines are mainly decoctions and compound pills, which have the disadvantages of large dosage, inconvenient carrying, and slow onset of action.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound red sage root freezing-dried powder injection containing tanshinol and its preparation method
  • Compound red sage root freezing-dried powder injection containing tanshinol and its preparation method
  • Compound red sage root freezing-dried powder injection containing tanshinol and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] a. Take 1000g of salvia miltiorrhiza, 850g of notoginseng, and 5g of borneol for later use;

[0169] b. The above Danshen and Panax notoginseng were extracted twice with water, each time for 1 hour, the extracts were combined and concentrated to obtain the Danshen extract and Sanqi extract; the borneol was dissolved with an appropriate amount of ethanol, and clathrated with β-cyclodextrin;

[0170] Dissolve Danshen extract and Panax notoginseng extract in appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, freeze-dry , that is.

[0171] Measure the content of Danshensu in the freeze-dried powder injection according to high performance liquid chromatography (Appendix VI D of Chinese Pharmacopoeia 2005 edition);

[0172] Chromatographic conditions and system suitability test: use octadecylsilane bonded silica gel as filler; Acetoni...

Embodiment 2

[0177] a. Take 4000g of salvia miltiorrhiza, 260g of notoginseng, and 50g of borneol for later use;

[0178] b. The above Danshen and Panax notoginseng were extracted with ethanol respectively to obtain Danshen extract and Sanqi extract; borneol was dissolved with an appropriate amount of ethanol and clathrated with β-cyclodextrin;

[0179] Dissolve Danshen extract and Panax notoginseng extract in appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, freeze-dry , that is.

[0180] Measure content according to embodiment 1 method, this product contains salvia miltiorrhiza with Danshensu (C 9 h 10 o 5 ), the content is 5.25-38.75mg / g freeze-dried powder solids.

Embodiment 3

[0182] a. Take 1200g of salvia miltiorrhiza, 300g of notoginseng and 6g of borneol for later use;

[0183] b. The above Danshen and Panax notoginseng were extracted with water respectively, alcohol precipitation was carried out three times, the extracts were combined and concentrated to obtain the Danshen extract and the Sanqi extract;

[0184] Dissolve Danshen extract and Panax notoginseng extract in appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, freeze-dry , that is.

[0185] Measure content according to embodiment 1 method, this product contains salvia miltiorrhiza with Danshensu (C 9 h 10 o 5 ), the content is 2.25-24.15mg / g freeze-dried powder solids.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
Login to View More

Abstract

The invention provides a compound red sage root freeze dried powder injection containing Danshensu and its preparing process, wherein the injection comprises red sage root, notoginseng and borneol. The preparing process consists of extracting root of red rooted saliva and pseudo-ginseng to obtain red sage root extract and pseudo-ginseng extract, dissolving baras camphor with right amount of ethanol, coating with beta-cyclodextrin, charging injection for water into red sage root extract, notoginseng or red sage root and notoginseng extracts for dissolving, boiling, cooling down, filtering, mixing filtrate with baras camphor beta-CD inclusion solution, charging mannitol, adding right amount of water for injection, adjusting pH, and finally freeze-drying. In the freeze dried injection, Calculated by the total amount of ginseng saponin Rg1 (C27H32O16), ginseng saponin Rb1 and notoginseng saponin R1, the total content of notoginseng active constituent is 12.5-50.0mg / g freeze-dried powder solid.

Description

technical field [0001] The invention belongs to the field of medicine, and more specifically relates to a compound salvia miltiorrhiza freeze-dried powder injection made from traditional Chinese medicines. Background technique [0002] In most western countries, the death of cardiovascular disease accounts for about half of the total number of deaths, among which coronary heart disease takes the first place, accounting for more than 50% of the number of cardiovascular deaths. As an Asian country, coronary heart disease is not as common in China as in European and American countries, but it has increased in recent years. According to the vital statistics released by the Ministry of Health, in 1957 urban residents died of cardiovascular and cerebrovascular diseases accounted for 12.0% of the total, which rose to 16.6% in 1989, and the ranking of the cause of death rose from the 5th and 7th to the 2nd and 3rd. It can be seen that the incidence of coronary heart disease is incr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/19A61P9/10G01N30/02G01N33/15A61K31/045
Inventor 叶正良李永强郑永锋周桂荣
Owner TIANJIN TASLY ZHIJIAO PHARMA