Application of flax root extract in preparing medicine for preventing and treating hepatitis

A technology of root extract, flax, applied in the field of application in the preparation of drugs for the prevention and/or treatment of hepatitis

Inactive Publication Date: 2007-12-19
龙井民康生物制品厂 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the literature records that flax root can also be used medicinally, the actual situation of comprehensive utilization of flax is still to

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 flax root extract

[0036] 200 kg of flax (Linum usitatissimum L.) roots were extracted three times with 85% ethanol under reflux, the extracts were combined, and the ethanol was recovered under reduced pressure to obtain a crude extract.

[0037] The crude extract was dissolved in water, then extracted three times with ethyl acetate of the same volume as water, and the ethyl acetate portion was discarded.

[0038] The aqueous layer was extracted three times with the same volume of n-butanol; the n-butanol layers were combined.

[0039] The n-butanol extract was first extracted three times with the same volume of 5% aqueous sodium bicarbonate solution, and then extracted with water until neutral.

[0040] Recover the solvent under reduced pressure to obtain the n-butanol extract, which is the flax root extract.

Embodiment 2

[0041] Embodiment 2, flax root extract acute toxicity study

[0042] (1) Test animals

[0043] ICR mice, male, weighing 18-22 grams, provided by Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: SCDK (Beijing) 2002-0003

[0044] (2) Test drugs

[0045] Flax root extract, yellow-white powder, stored in the dark at 2-5°C, provided by Professor Qin Hailin of our institute, suspended in 0.5% CMC-Na when used.

[0046] (3) Test method

[0047] Ten mice were orally administered flax root extract at a concentration of 250 mg / ml, and each mouse was administered with a volume of 0.8 ml (ie the highest concentration and maximum volume). Within 7 days after administration, the signs and death of the mice were observed.

[0048] (4) Test results

[0049] After oral administration of flax root extract in mice, the signs did not change significantly. No deaths occurred.

[0050] (5 Conclusion

[0051] Oral administration of flax root extract 10g / kg to mice ...

experiment example 3

[0053] Experimental example 3, the effect of flax root extract on ConA-induced acute liver injury in mice

[0054] (1) Test animals

[0055] ICR mice, male, weighing 18-22 grams, provided by Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: SCDK (Beijing) 2002-0003

[0056] (2) Test drugs

[0057] Flax root extract, yellow-white powder, stored in the dark at 2-5°C, provided by Professor Qin Hailin of our institute, suspended in 0.5% CMC-Na when used.

[0058] (3) Positive control drug

[0059] Bicyclol, white powder, provided by Peking Union Medical College Pharmaceutical Factory, batch number 20030801, suspended with 0.5% CMC-Na when used.

[0060] 4.ConA

[0061] ConA was purchased from Sigma Corporation.

[0062] (4) Test method

[0063] The animals were randomly divided into 6 groups, 7 animals in each group, which were normal control group, ConA model group, flax root extract high-dose administration group, flax root extract medium-dose adm...

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PUM

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Abstract

The present invention discloses one kind of flax root extract, and its preparation process, medicine composition and application in preparing medicine for preventing and treating hepatitis.

Description

technical field [0001] The present invention relates to an extract of flax root, a preparation method of the extract, a pharmaceutical composition containing the extract and an application of the extract in preparing medicines for preventing and / or treating hepatitis. Background technique [0002] Flax (Linum usitatissimum L.) is a plant of the genus Linaceae, which is widely distributed all over the country. The plant is an annual herb with smooth stems and a plant height of 0.75-1.20m. There are branches at the top, which are umbrella-shaped; the cross-section of the stem is round and gray-green; the flax leaves are gray-green, alternate, with linear lanceolate edges, dense leaves, flat surface, 2-3.5cm long, 22cm wide ~4cm, the base of the leaf gradually narrows, blue-green; flowers are scattered on the top of the pedicel, the pedicel is erect, 2-7mm long, in racemes or open cymes; sepals are 5, narrow and long or long ovate, 5-7mm long , entire, without nectary glands,...

Claims

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Application Information

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IPC IPC(8): A61K36/55A61P1/16A61K125/00
Inventor 秦海林母海成李志宏张霞
Owner 龙井民康生物制品厂
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