External composition for skin

A composition for external use, a technology for skin, applied in the directions of skin care preparations, cosmetic preparations, cosmetics, etc., and can solve problems such as unknown

Active Publication Date: 2008-01-02
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on adding retinol or its derivatives to a composition in which urea is added at a high concentration of 10% by weight or more relative to the compositi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 7-16

[0182] Preparation examples are listed below. It should be noted that, when the unit is not specified, the addition amounts in the following examples all represent % by weight.

[0183] Table 4

[0184]

g / 100g

Example 7

(ointment)

Example 8

(gel-like)

Example 9

(lotion form)

urea

10

10

20

Retinyl acetate*1

0.01

0.10

-

Retinyl palmitate*1

-

-

0.3

d1-alpha-tocopherol

-

-

2.0

Delta-tocopherol

0.5

1.0

-

Sodium edetate

0.01

0.03

0.1

Butylated hydroxytoluene

0.05

0.01

0.1

white vaseline

20

-

1

liquid paraffin

10

-

2

Paraffin

10

-

-

1,3-Butanediol

2

20

2

ethanol

-

10

-

cet...

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PUM

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Abstract

The invention provides a skin external preparations, with excellent use feeling, stability and security even containing urea of high concentration. The retinol and/or its derivative is added in the skin external preparations containing 10 to 25 weight% of urea to increase the use feeling and stability, moisture-retention and security. Furthermore, the tocopherol and//or its derivative is added in the skin external preparations to more markedly give play to the said effects.

Description

technical field [0001] The present invention relates to a composition for external use on skin which is excellent in usability, stability, moisture retention and safety. More specifically, the present invention relates to compositions for external use on the skin containing urea and retinol and / or derivatives thereof. Background technique [0002] Urea is a component widely used in external skin compositions as a moisturizing agent, a penetration aid, a rough skin improving agent, a skin softening agent, a cell activating agent, and the like. In order to use urea to produce significant moisturizing effect and skin softening effect, it is necessary to add a relatively high concentration of urea to the composition for external use on the skin. However, in a composition in which urea is added at a high concentration of 10% by weight or more, urea tends to be precipitated, and the original pharmacological action of urea is weakened, and the usability during application is impai...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/89A61K8/02A61Q19/00A61K8/40
Inventor 平山良之佐藤范和桑原亚希子
Owner ROHTO PHARM CO LTD
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