18F-FDG automatization synthetic method and device

Abstract

Disclosed is an 18F-FDG automatic synthesis method and equipment, relating to prepare the 18F-FDG through a nucleophilic reaction. In the invention, a vessel for reaction solution is communicated with a reaction vessel through a valve and a pipe. Under the control of a stepping motor, the reaction solution can be put into the reaction vessel in batch according to the need. The reaction vessel is communicated with plurality sets of product collecting devices through the pipe and a valve with one inlet and a plurality of outlets with which the product in the reaction vessel can be moved into the collecting devices. With the above-mentioned method, when the nucleophilic reaction is processed and the sealed reaction vessel is between 100 DEG C to 120 DEG C, the water removal and the nucleophilic reaction can be processed in one heating device. The equipment can realize one time charge and multiple synthesis. The method simplifies the heating device. The invention is mainly used in one-time charge and batch production of the radiopharmaceuticals.

Description

technical field [0001] The present invention relates to a radiopharmaceutical 2-fluoro-18 generation-2 deoxy-β-D-glucose ( 18 F-FDG) automated synthesis method and equipment, especially related to the preparation by nucleophilic reaction 18 Methods and apparatus for F-FDG. Background technique [0002] 18 F-FDG is widely used in the diagnosis of malignant tumors, the measurement of glucose metabolism in the myocardium and brain, etc. At present, the widely used international 18 The F-FDG synthesis method is based on the principle of selective stereonucleophilic reaction reported by Hamacher K in 1986 to synthesize β-D-2-fluorodeoxyglucose. With the clinical 18 The demand for F-FDG is increasing, and researchers have mainly carried out research from two aspects: (1) Improving the efficiency of a single synthesis. A single high-efficiency synthesis not only improves 18 The output of F-FDG also saves the production 18 Cost of F-FDG. but due to 18 The half-life of F is...

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Problems solved by technology

However, the existing operation of transferring the reaction solution into the reaction container generally adopts the pneumatic / negative pressure method, and it is still impossible to achieve a controllable transfer of the reaction solution.

[0003] In addition, as mentioned above, the existing synthetic methods all use the principle of nucleophilic reaction, the process of this reaction needs to remove water by heating, and then complete the nucleophilic reaction under heating conditions

However, since water removal must be above 100°C, and the boiling point of acetonitrile, the reagent required for the reaction, is 81°C, the intermediate product 18 The boiling point of FDG is 82°C, so this different heating temperature puts higher requirements on the heating device

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