18F-FDG automatization synthetic method and device

A 18F-FDG, automatic synthesis technology, applied in chemical instruments and methods, organic chemistry, sugar derivatives, etc., can solve the problem of inability to realize controllable pipetting of reaction solution, and achieve the effect of reducing space occupation and cost

Inactive Publication Date: 2008-01-16
张锦明 +1
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Problems solved by technology

However, the existing operation of transferring the reaction solution into the reaction container generally adopts the pneumatic/negative pressure method, and it is still impossible to achieve a controllable transfer of the reaction solution.
[0003] In addition, as mentioned above, the existing synthetic methods all use the principle of nucleophilic reaction, the process of this reactio

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  • 18F-FDG automatization synthetic method and device

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[0021] A sort of 18 The automatic synthesis equipment of F-FDG is as shown in the accompanying drawing. Wherein, the container 4 that holds K2.2.2 solution is connected with transfer bottle 1, the container 5 that holds anhydrous acetonitrile is connected with transfer bottle 2, the container 6 that holds trifluoromannose anhydrous acetonitrile solution is connected with transfer bottle 3 connected. The container 4 for the K2.2.2 acetonitrile solution containing potassium carbonate, the container 5 for anhydrous acetonitrile, and the container 6 for the anhydrous acetonitrile solution of mannose trifluoride are collectively referred to as containers for the reaction solution. The transfer bottles 1, 2, and 3 are respectively connected to the reaction vessel 9 through the two-position six-way valve V0, the three-inlet-one-outlet valves V1, V2, V3 and corresponding pipelines, and are all connected to the nitrogen storage device. An inlet end of the valve V0 communicates with t...

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Abstract

Disclosed is an 18F-FDG automatic synthesis method and equipment, relating to prepare the 18F-FDG through a nucleophilic reaction. In the invention, a vessel for reaction solution is communicated with a reaction vessel through a valve and a pipe. Under the control of a stepping motor, the reaction solution can be put into the reaction vessel in batch according to the need. The reaction vessel is communicated with plurality sets of product collecting devices through the pipe and a valve with one inlet and a plurality of outlets with which the product in the reaction vessel can be moved into the collecting devices. With the above-mentioned method, when the nucleophilic reaction is processed and the sealed reaction vessel is between 100 DEG C to 120 DEG C, the water removal and the nucleophilic reaction can be processed in one heating device. The equipment can realize one time charge and multiple synthesis. The method simplifies the heating device. The invention is mainly used in one-time charge and batch production of the radiopharmaceuticals.

Description

technical field [0001] The present invention relates to a radiopharmaceutical 2-fluoro-18 generation-2 deoxy-β-D-glucose ( 18 F-FDG) automated synthesis method and equipment, especially related to the preparation by nucleophilic reaction 18 Methods and apparatus for F-FDG. Background technique [0002] 18 F-FDG is widely used in the diagnosis of malignant tumors, the measurement of glucose metabolism in the myocardium and brain, etc. At present, the widely used international 18 The F-FDG synthesis method is based on the principle of selective stereonucleophilic reaction reported by Hamacher K in 1986 to synthesize β-D-2-fluorodeoxyglucose. With the clinical 18 The demand for F-FDG is increasing, and researchers have mainly carried out research from two aspects: (1) Improving the efficiency of a single synthesis. A single high-efficiency synthesis not only improves 18 The output of F-FDG also saves the production 18 Cost of F-FDG. but due to 18 The half-life of F is...

Claims

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Application Information

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IPC IPC(8): C07H5/02A61K51/04A61K101/02
Inventor 张锦明田嘉禾于生民周彤
Owner 张锦明
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