Dexamethasone sodium phosphate injection

A technology of dexamethasone sodium phosphate and injection, which is applied in the direction of drug delivery, organic active ingredients, and medical preparations containing active ingredients, etc. It can solve the problems of large potential harm to the human body and large cumulative volume, and achieve production cost reduction, The effect of stable product quality and saving production cost

Active Publication Date: 2010-10-06
TIANJIN PHARMA GROUP XINZHENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In the production process of dexamethasone sodium phosphate injection, the concentration generally adopted by manufacturers is about 30% (volume ratio; that is, 3000ml of medicinal propylene glycol needs to be added for every 10,000ml of dexamethasone sodium phosphate liquid medicine prepared) , although a single bottle contains a small amount of medicinal propylene glycol (the general specifications of dexamethasone sodium phosphate injection are 1ml:2mg, 1ml:5mg), but long-term use, the cumulative amount is still large, and the potential harm to the human body is relatively large

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, dexamethasone sodium phosphate injection, is made up of the phosphate buffer saline, dexamethasone sodium phosphate and injection water of the medicinal propylene glycol of 4% by volume ratio, 0.3% PH8.0, dexamethasone sodium phosphate content 2mg per ml injection.

Embodiment 2

[0021] Embodiment 2. In this embodiment, the content of dexamethasone sodium phosphate is 5 mg per ml of injection, and the others are the same as in Embodiment 1.

Embodiment 3

[0022] Embodiment 3, dexamethasone sodium phosphate injection, is made up of the phosphate buffer saline, dexamethasone sodium phosphate and water for injection of the medicinal propylene glycol of 5% by volume ratio, 0.4% PH8.0, dexamethasone sodium phosphate content 2mg per ml injection.

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PUM

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Abstract

Dexamethasone sodium phosphate injection comprises the medicinal propanediol with the volume ratio of 4 percent to 6 percent, the phosphate buffer of 0.3 percent to 0.5 percent with the PH value of 8.0, the dexamethasone sodium phosphate and the injection water. Content of the dexamethasone sodium phosphate is 2mg to 5 mg per ml. The application is safe and the cost is low in the present invention.

Description

technical field [0001] The invention belongs to the technical field of medical preparations, in particular to a dexamethasone sodium phosphate injection. Background technique [0002] Dexamethasone sodium phosphate, chemical name 16α-methyl-11β,17α,21-trihydroxy-9α-flupregna-1,4-diene-3,20-dione-21-phosphate disodium salt , is an adrenal cortex hormone drug with anti-inflammatory, anti-allergic, anti-rheumatic, and immunosuppressive effects. The mechanism of action is: (1) Anti-inflammatory effect: it can reduce and prevent the response of tissues to inflammation, thereby reducing the manifestation of inflammation. It can inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators. (2) Immunosuppressive effects: including preventing or inhibiting cell-mediated immune responses, delayed allergic r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P37/08A61P37/06A61K31/573A61P29/00A61K9/08
Inventor 周遂成陈智锋
Owner TIANJIN PHARMA GROUP XINZHENG
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