Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Transdermal paster containing bulleyaconitine A and its preparation method

A technology of aconitin and transdermal patch, which is applied in the field of transdermal patch of aconitin and its preparation, can solve the problems of high skin irritation and poor stability, and achieve safety and ease of use Effect

Inactive Publication Date: 2008-02-13
KPC PHARM INC
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of the preparation in this patent are as follows: the irritation to the skin is still relatively large when the drug is used; the patch contains a penetration enhancer, and the aconitin will be adsorbed on the backing, resulting in poor stability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Transdermal paster containing bulleyaconitine A and its preparation method
  • Transdermal paster containing bulleyaconitine A and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The transdermal patch described in this embodiment is a drug storage (adhesive skeleton type) patch, which consists of a backing layer, a protective layer and a drug-containing adhesive skeleton three-layer structure, and the materials used in each layer are as follows:

[0023] Backing layer: Polyurethane film

[0024] Protective layer: PTFE film

[0025] Drug storage (drug-containing adhesive matrix):

[0026] Drug storage prescription (100 stickers):

[0027] Silicone PSA 16g

[0028] Aconitin 0.4g

[0029] Preparation process: Take the prescribed amount of aconitin and silicone pressure-sensitive adhesive, add appropriate amount of ethyl acetate to dissolve, adjust to a suitable consistency, apply on the protective layer, control the thickness of the coating, dry, and cover the back Lining, cut to the appropriate shape and size. Control patch area is 10cm 2 , Each patch contains 4mg of medicine.

[0030] The time lag of the aconitin patch described in this em...

Embodiment 2

[0032] The transdermal patch described in this example is an adhesive skeleton patch, consisting of a three-layer structure of a backing layer, a protective layer, and a drug-containing adhesive skeleton. The materials used in each layer are as follows:

[0033] Backing layer: non-woven fabric

[0034] Protective layer: PTFE film

[0035] Drug-containing adhesive matrix:

[0036] Adhesive frame prescription (100 stickers):

[0037] Silicone pressure sensitive adhesive 10g

[0038] Aconitin 0.6g

[0039] Preparation process: Take the prescribed amount of aconitin and silicone pressure-sensitive adhesive, add an appropriate amount of ethyl acetate to dissolve, adjust to a suitable consistency, coat on the protective layer, control the thickness of the coating, dry, and cover the back Lining, cut to proper shape. Control patch area is 10cm 2 , Each patch contains 6mg of medicine.

[0040] The time lag of the aconitin patch described in this embodiment is 10.5h, and the tra...

Embodiment 3

[0042] The transdermal patch described in this example is an adhesive skeleton patch, consisting of a three-layer structure of a backing layer, a protective layer, and a drug-containing adhesive skeleton. The materials used in each layer are as follows:

[0043] Backing layer: non-woven fabric

[0044] Protective layer: anti-stick paper

[0045] Drug-containing adhesive matrix:

[0046] Adhesive frame prescription (100 stickers):

[0047] Polyacrylate pressure sensitive adhesive 20g

[0048] Aconitin 1.5g

[0049] Preparation process: Take the prescribed amount of aconitin and polyacrylate pressure-sensitive adhesive, add appropriate amount of ethyl acetate to dissolve, adjust to a suitable consistency, coat on the protective layer, control the thickness of the coating, dry, and cover Backing layer, cut to appropriate shape. Control patch area is 10cm 2 , Each patch contains 15mg of medicine.

[0050] The time lag of the aconitin patch described in this embodiment is 7....

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides an external patch for improving pain and inflammation, which particularly relates to a transdermal patch containing the bulleyacinitine A and the corresponding production method.

Description

technical field [0001] The invention relates to a transdermal patch of aconitin with analgesic and anti-inflammatory effects and a preparation method thereof. Background technique [0002] Most diseases and physical injuries are accompanied by pain and inflammation. Among various types of pain, chronic pain due to malignant and inflammatory diseases is excruciating due to its long duration. Many diseases such as cancer and arthritis can cause chronic pain and inflammation, which make the patient gradually debilitated. [0003] Because aconitine alkaloids generally have the effect of improving pain and anti-inflammation, pharmaceutical workers have developed compounds with relatively strong activity and small side effects as drugs according to the activity of specific aconitine drugs and the magnitude of side effects. , grass-aconitine is a typical example. [0004] Publication number is that the Chinese patent of CN1450883A has announced " transdermal delivery system of a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/445A61M37/00A61P29/00
Inventor 翁伟宇张伟徐惠南黄照昌杨兆祥张建芳
Owner KPC PHARM INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com