Preparation method for octacosanol

A technology of stearyl alcohol and stearyloxy, applied in the field of organic synthesis, can solve the problems of poor atom economy and low efficiency, and achieve the effects of low toxicity, simple process and abundant sources

Inactive Publication Date: 2008-02-13
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new compound called octacosaic acid can be made by reacting two different chemicals together at once (one after another). It's less expensive compared to other methods like synthesis but it still produces good results without causing harmful side products that may affect human health if consumed over time.

Problems solved by technology

The technical problem addressed in this patented text relates to obtaining high concentrations of an active ingredient called olecocoa extract from naturally occurring plants like caffeine tree roots that can be easily separated for further analysis without losing valuable flavorings during processing steps.

Method used

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  • Preparation method for octacosanol
  • Preparation method for octacosanol
  • Preparation method for octacosanol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Step 1: Preparation of 10-bromo-n-decyl alcohol (2)

[0033] Add 1,10-decanediol (1) (11.6g, 67mmol) and toluene (200mL) into a 500mL three-necked flask equipped with a water separator, flow condenser and constant pressure dropping funnel, and use The oil bath was heated to reflux. After the solid was dissolved, 40% HBr (16.3 mL, 80 mmol) was slowly added dropwise from the dropping funnel, and the water generated by the reaction was separated from the water separator. After the conversion of (1) is complete, cool to room temperature and transfer to a separatory funnel, wash with saturated sodium bicarbonate (100mL), (100mL) and saturated sodium chloride (100mL) successively, dry over anhydrous sodium sulfate, and filter The toluene was distilled off under reduced pressure, and the crude product was subjected to flash column chromatography or distillation under reduced pressure to obtain 10-bromo-n-decanol (2) (14.3 g, 90%) as an oily liquid. IR (film, cm -1 )v max : ...

Embodiment 2

[0043] Similar to Example 1, the difference is that the solvent used in step 2 is dichloromethane, and the amount of p-toluenesulfonic acid is 0.2 molar multiples of (2).

Embodiment 3

[0045] Similar to Example 1, the difference is that the solvent used in step 4 is anhydrous ether, and the concentration of 2-(10-bromo-n-decyloxy)-tetrahydropyran (3) in anhydrous ether is 0.2mol / L, the temperature of the coupling reaction is -40°C, the amount of cuprous iodide is 0.45 mole multiple of (3), and the reaction time after adding octadecylsulfonate (6, R=Ts) is 2h.

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Abstract

The present invention discloses a preparation method for 1-Octacosanol, which relates to a preparation method for an advanced alcohol, in particular to the preparation method for 1-Octacosanol; the method belongs to the organic synthesized region. The utility mode provides a preparation method for 1-Octacosanol, which has the advantages of abundant raw resource, simple technical, high purity and extracting ratio as well as easy to be produced with large-scale. The method can prepare 2 12-11- 2 1 1 Decyl alcohol (2), and can prepare 2-(3, 3-triethoxypropane)-4-aminotetrahydropyran (3), and the method can prepare Ph esters Phenyl C10-18-alkylsulfonate (6), and can prepare Octacosane 2- nbspgrama-Octalactone-4-aminotetrahydropyran (7) and can prepare 1-Octacosanol (8). The material is easy to be obtained with simple technical, high chemical absorbing ratio and high product purity; the method is easy to be industrial and is not polluting to the environment.

Description

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Claims

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Application Information

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Owner XIAMEN UNIV
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