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Traditional Chinese medicine for treating chronic hepatitis B and its preparation process

A chronic hepatitis B, composition technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as unsatisfactory effect and easy drug resistance

Inactive Publication Date: 2008-03-26
北京星昊嘉宇医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the antiviral drugs used to treat hepatitis B at home and abroad mainly include interferon and lamivudine, but the effect is not very satisfactory, and drug resistance is easy to develop

Method used

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  • Traditional Chinese medicine for treating chronic hepatitis B and its preparation process
  • Traditional Chinese medicine for treating chronic hepatitis B and its preparation process
  • Traditional Chinese medicine for treating chronic hepatitis B and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) Weighing 200g of Phyllostachys phylloxera, 800g of Gallbladder Folium;

[0061] (2) The raw material is pulverized, and 8 times the amount of deionized water is added to reflux extraction for 4 times, each time for 0.5 hours, filtered, and the filtrates are combined;

[0062] (3) Concentrate the filtrate under reduced pressure at 70°C to a thick paste, add 5% ethanol in an amount of 2mL / g thick paste, reflux for 0.5 hours, let cool at room temperature, transfer to a cold place for 12 hours at low temperature, filter or Centrifuge, take the filtrate or supernatant, and concentrate under reduced pressure at 70°C until there is no alcohol smell, so that the relative density of the concentrated solution is 1.05 to obtain a concentrated solution;

[0063] (4) Put the concentrated solution on the Diaion HP-20 type macroporous adsorption resin column, wash it with water until the color of the eluent becomes light, then use 45% ethanol to elute until the reaction of the elu...

Embodiment 2

[0066] (1) Weighing 800g of Phyllostachys phylloxera, 200g of Gallbladder Folium;

[0067] (2) The raw material was pulverized, and 16 times the amount of 60% ethanol was added to extract and reflux for 1 time, reflux for 3 hours, and filter to obtain the filtrate;

[0068] (3) Concentrate the filtrate under reduced pressure at 40°C to a thick paste, add 15% ethanol in an amount of 4mL / g thick paste, reflux for 1 hour, let cool at room temperature, transfer to a cold place for 36 hours at low temperature, filter or Centrifuge, take the filtrate or supernatant, and concentrate under reduced pressure at 40°C until there is no alcohol smell, so that the relative density of the concentrated solution is 1.30 to obtain a concentrated solution;

[0069] (4) The concentrated solution is extracted with n-butanol saturated with water, the amount of n-butanol is 0.5 times that of the concentrated medicinal solution, and the number of extractions is 6 times. The n-butanol extracts are com...

Embodiment 3

[0072] (1) Take by weighing 500g of Phyllostachys phylloxera, 500g of Gallbladder Folium;

[0073] (2) The raw material is pulverized, and 12 times the amount of 30% ethanol is added to reflux extraction twice, each time for 2 hours, filtered, and the filtrates are combined;

[0074] (3) Concentrate the filtrate under reduced pressure at 60°C to a thick paste, add 10% ethanol in an amount of 3mL / g thick paste, reflux for 45min, let cool at room temperature, transfer to a cold place for 24 hours at low temperature, filter or centrifuge , take the filtrate or supernatant, and concentrate under reduced pressure at 60°C until there is no alcohol smell, so that the relative density of the concentrated solution is 1.20 to obtain a concentrated solution;

[0075] (4) Put the concentrated solution on the AB-8 type macroporous adsorption resin column, wash it with water until the color of the eluent becomes light, and then use 75% ethanol for elution, until the reaction of the eluent f...

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Abstract

The present invention discloses a Chinese medicine composition for curing chronic hepatitis B and its preparation method. It is made up by using Chinese medicinal materials of phyllanthus, pretty swertia and agrimony through a certain preparation process. Said Chinese medicine composition can be made into various oral preparations.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a raw material drug composition composed of Phyllostachys phylloxera and any one selected from A. , the composition is mainly used for treating chronic hepatitis B. Background technique [0002] At present, about 2 billion people in the world have been attacked by hepatitis B virus (HBV), and 350 million of them have developed chronic HBV infection. Chronic hepatitis B can develop into liver cirrhosis and liver cancer, and about 1 million people worldwide die from HBV infection-related diseases every year. my country is a high-incidence area of ​​hepatitis B, about 50% of people have been infected with HBV, and chronic HBV carriers account for 9.75% of the national population. At present, the antiviral drugs used to treat hepatitis B at home and abroad mainl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61P1/16A61P31/20
Inventor 张树祥熊国裕方文建崔娜娜
Owner 北京星昊嘉宇医药科技有限公司
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