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Usage of purplish plastocyanin as insulin sensitization agent as well as its preparation

An insulin sensitizer and violetine technology, which is applied to the application of violetine in the preparation of insulin sensitizers, and the field of preparations in which violetine is an active ingredient

Inactive Publication Date: 2008-04-09
GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent number applied by the applicant is ZL03117188.5, and the Chinese invention patent titled "Viocyanin Compound, Its Preparation Method and Its Use" discloses that violacyanin can be used in the preparation and prevention of hepatitis B, diabetes, and anti-diabetes. Application in oxidizing medicines or health products, or as a coloring agent, but the insulin-sensitizing effect of violatin, especially the insulin-sensitizing effect that can improve liver and kidney lesions at the same time, has not been reported

Method used

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  • Usage of purplish plastocyanin as insulin sensitization agent as well as its preparation
  • Usage of purplish plastocyanin as insulin sensitization agent as well as its preparation
  • Usage of purplish plastocyanin as insulin sensitization agent as well as its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of violacein

[0016] Get Peristrophe baphia (Spreng.) Bremek. [Peristrophe roxbueghiana (schult) Bremek]) fresh branches and leaves 2kg, place in the round-bottomed flask of 10L rotary evaporator, rush into and boil for 3 minutes quickly (excluding dissolved oxygen) boiling water 8L, placed in 86 ℃ water bath. Rotate the flask to make the temperature uniform, and the boiling water directly contacts the indigo material at room temperature (22° C.), so that the material is heated to 80° C. within 2 minutes. The mixed material was kept at 86°C for 90 minutes, the extract was poured out, and the residue was taken out; 5 L of water was added to the residue, boiled for extraction for 10 minutes, and filtered. Combine the above two extracts to obtain 13.2L extract (T001);

[0017] Add formic acid to the above extract (T001) to adjust the pH to pH 5.0, put it on an Amberlite XAD-16 macroporous adsorption resin column (1000 g), wash it with 10 L ...

Embodiment 2

[0027] Example 2: Preparation of an insulin sensitizer with violacein as an active ingredient

[0028] Weigh 5 grams of violacyanin prepared by the method described in Example 1, without adding any auxiliary materials, and bottle it.

Embodiment 3

[0029] Example 3: Preparation of Violet Cyanine Capsules with Violet Cyanine as Active Ingredient

[0030] Violet blue pigment capsules include: capsule core and capsule shell. The capsule core contains 13% of violacein and 87% of starch by weight percentage. Dry the starch, pass it through a No. 7 sieve, weigh 20 grams for later use; take 3 grams of Violet Blue and 20 grams of dry starch, mix evenly, pass through a No. 7 sieve twice, and put them into capsules. Make 100 capsules in total, each containing 30mg violacein.

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Abstract

The invention discloses the usage and the formulation of Zilanine used as insulin sensitizing agent, in particular, the usage of the Zilanine of the invention is an application in preparing the insulin sensitizing agent which can improve pathological change of liver, and the application in preparing the insulin sensitizing agent which can improve pathological change of kidney; the formulation of the Zilanine used as the insulin sensitizing agent of the invention is the insulin sensitizing agent which can improve the pathological change of the liver and is prepared with the Zilanine as an effective ingredient, and the insulin sensitizing agent which can improve the pathological change of the kidney and can be prepared with the Zilanine as the effective ingredient.

Description

(1) Technical field: [0001] The present invention relates to a new application of violacyanin, specifically the application of violacyanin in the preparation of insulin sensitizers; the present invention also relates to a preparation with violacyanin as an active ingredient. (two) background technology: [0002] In the past 20 years, scientific research has found that type II diabetes, high blood pressure, obesity, non-alcoholic fatty liver, and cardiovascular and cerebrovascular thrombotic diseases belong to metabolic syndrome, and their common basis is insulin resistance. Metabolic syndrome is also known as insulin resistance syndrome. [0003] With the change of environment and lifestyle, the incidence of metabolic syndrome is high and the growth trend is rapid. For example, type II diabetes, the current incidence rate is 30% higher than that of 4 years ago. There are 246 million patients in the world, and there are 40 million in my country. Overweight adults in my count...

Claims

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Application Information

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IPC IPC(8): A61K31/395A61P3/10A61P5/50
Inventor 谢运昌蒋小华何成新文永新李娟
Owner GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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