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Application of active component of cape jasmine for treating senile dementia

An effective part and geriatric technology, applied in the field of application of the effective part of gardenia in the treatment of senile dementia, can solve the problems that there are no research reports on the effect of gardenia on senile dementia

Inactive Publication Date: 2008-04-23
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gardenia is rich in natural resources, and no reports of toxicity have been seen. So far, we have not seen research reports on the effect of Gardenia on senile dementia

Method used

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  • Application of active component of cape jasmine for treating senile dementia
  • Application of active component of cape jasmine for treating senile dementia
  • Application of active component of cape jasmine for treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Gardenia 1 kg 70% ethanol reflux extraction 3 times, each time 1 hour, combined extracts, concentrated extracts under reduced pressure to no alcohol smell, combined concentrates were filtered and diluted 10 times, slowly passed through pre-treated 2kg macropores Resin column, the medicinal solution is all washed with distilled water after passing through the macroporous resin column, and then eluted with 5% ethanol to remove impurities, then eluted with 20% ethanol for 5 times the column volume, collected the eluate, evaporated to dryness under reduced pressure, The effective fraction with a geniposide content of more than 50% is obtained.

Embodiment 2

[0034] Add 1 kg of Gardenia jasminoides and add 10 times the amount of 55% ethanol to soak for 24 hours, then percolate, combine the percolation liquid, concentrate the extract under reduced pressure until it has no alcohol smell, degrease with petroleum ether, extract with n-butanol, and evaporate to dryness under reduced pressure to obtain The content of geniposide is more than 50% in effective parts.

[0035] Pharmacological experiment

experiment example 1

[0036] Experimental example 1. The effect of the test product gardenia on the memory ability of mice with memory acquisition impairment induced by cycloheximide

[0037] Objective: To observe the effect of the active parts of Gardenia jasminoides on the memory ability of animals with memory acquisition impairment.

[0038] Materials and methods

[0039] Test product: effective parts of Gardenia jasminoides, yellow powder, dissolved in double distilled water.

[0040]Reagent: cycloheximide, sigma company, lot number: 091K11001.

[0041] Donepezer (Aricept), manufactured by PFIZER PGM in France, repackaged by Eisai (China) Pharmaceutical Co., Ltd., batch number: 4221903.

[0042] Animals: Kunming mice, male, weighing 20-24 grams. Provided by the Institute of Animals, Academy of Medical Sciences, certificate number: SCXK (Beijing) 2004-0001

[0043] instrument:.

[0044] Steps: Mice were randomly divided into six groups: normal control group, model group, donepazil (0.75mg / k...

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PUM

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Abstract

The present invention discloses an effective component extracted from gardenia fruit, it contains (by wt%) at least 50% of gardenoside. Said invention also discloses preparation method of said effective component, medicine composition containing said effective component and application of said effective component in preparation of medicine for preventing and / or curing senile dementia.

Description

technical field [0001] The present invention relates to the effective part extracted from gardenia, the preparation method of the effective part, the pharmaceutical composition containing the effective part, and the use of the effective part and its pharmaceutical composition as medicine, especially in the preparation of preventive and / or the application in the treatment of senile dementia medicine. Background technique [0002] Senile dementia is a common and frequently-occurring disease that endangers the physical and mental health of the elderly. At present, the prevalence of senile dementia in people over 65 years old is about 10% in the world, and it can reach 47% over 85 years old. In developed countries, this disease ranks fourth in the cause of death, second only to heart disease. Cancer and stroke. The prevalence of senile dementia in my country is slightly lower than that in developed countries, but with the development of my country's economy and culture, life ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61P25/28C07H17/04C07H1/08
Inventor 张东明朱海波杨敬芝渠凯张岭
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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