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Synthesis of ferulic acid monoglyceride by quadratic universal rotational regression and response surface method combined with enzyme

A technology of ferulic acid monoglyceride and response surface method, which is applied in the field of enzymatic synthesis of ferulic acid monoglyceride, can solve the problems of reducing selectivity, reducing the yield of ferulic acid monoglyceride, etc., so as to avoid blindness. Effect

Inactive Publication Date: 2008-06-18
DONGHUA UNIV
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Problems solved by technology

The current preparation method is mainly based on the transesterification reaction of ferulic acid ester and triacylglyceride, but in the preparation process, in addition to ferulic acid monoglyceride, there is also a large amount of ferulic acid diglyceride , reducing the yield of monoglyceride ferulic acid and reducing the selectivity of the reaction

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  • Synthesis of ferulic acid monoglyceride by quadratic universal rotational regression and response surface method combined with enzyme
  • Synthesis of ferulic acid monoglyceride by quadratic universal rotational regression and response surface method combined with enzyme

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Embodiment 1

[0023] 1. Selection of ternary medium for reaction system

[0024] According to its LgaP value, (P value is the partition coefficient ratio of solvent in n-octanol and water, and the larger the LgP, the stronger the hydrophobicity of the solvent), select three kinds of solvents from the middle, middle and low areas respectively. Toluene (LgP=1.5), tert-butanol (LgP=2), cyclohexane (LgP=3.5) constitute the ternary system of the reaction medium.

[0025] 2. Establish the objective function

[0026] Y=β 1 x 1 +β 2 x 2 +β 3 x 3 +β 1 beta 2 x 1 x 2 +β 1 beta 3 x 1 x 3 +β 2 beta 3 x 2 x 3

[0027] where Y is the response value, i.e. variable (regioselectivity), β 1 , β 2 , β 3 , β 1 beta 2 , β 1 beta 3 , β 2 beta 3 are the interaction coefficients of each independent variable, X 1 、X 2 、X 3 They represent tert-butanol, toluene and cyclohexane respectively, and the total amount of reaction medium is 3ml.

[0028] 3. Analyze the objective function accor...

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Abstract

The invention relates to a method that quadratic general revolving regression and response surface methodology combined with enzymatic reaction to synthesize ferulic monoglyceride. The steps include: (1) selecting three reaction medium solvent according to the solvent polarity; (2) designing different proportions of the reaction media of the three solvent and establishing objective functions according to the quadratic general revolving regression; (3) analyzing the objective functions through the response surface methodology to obtain fourteen reaction media combinations with different proportions; (4) implementing the enzymatic reaction in the different media combinations; (5) comparing the conversion rate of the transesterification reaction and the selective predictive value with the actual measured value and detecting the analysis results. The method can systematically, rapidly and effectively prepare the ferulic monoglyceride and greatly improve the selectivity of the reaction while improving the yield.

Description

technical field [0001] The invention belongs to the field of enzymatic synthesis of ferulic acid monoglyceride, in particular to the enzymatic synthesis of ferulic acid monoglyceride by the combination of secondary general rotation regression and response surface method. Background technique [0002] As an important variety of polyol-type nonionic surfactants, monoglyceride has the characteristics of emulsification, antistatic, lubrication, etc., and has the advantages of safety, nutrition, and good processing adaptability, so it is widely used in food, medicine, and cosmetics. field. In recent years, with the increase of people's requirements for functional substances, the study of endowing monoglycerides with more physiological activities has attracted widespread attention. [0003] Ferulic acid is a kind of phenolic acid derivatives with various physiological activities existing in plants. However, its short carbon chain limits its application in other fields. Combinin...

Claims

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Application Information

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IPC IPC(8): C12P7/62
Inventor 朱利民郑妍权静蒋波
Owner DONGHUA UNIV
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