25 results about "Solvent polarity" patented technology

The invention discloses a method for detecting sweet-scented osmanthus aroma components in sweet-scented osmanthus wine, which comprises the following steps: diluting a wine sample, adding salt until the wine sample is saturated, and then carrying out liquid-liquid micro-extraction by using a mixed solvent of absolute ether and ethyl acetate in a specific ratio, the volume fraction of the ethyl acetate being 3-5%; after oscillation, ultrasonic-assisted extraction and centrifugal separation, an organic phase is taken for dehydration, a gas chromatograph-mass spectrometer is used for analysis, and an internal standard method is adopted for quantification. By optimizing the polarity of the solvent, various aroma components (such as leaf alcohol, linalool oxide, linalool, ionone, tea aroma spirane and the like) from strong polarity to weak polarity can be effectively covered, and balanced and efficient extraction under a single extraction step is realized. The method is easy and convenient to operate, high in recovery rate, good in reproducibility and suitable for quality evaluation and production process control of the osmanthus fragrans wine.

The invention relates to the technical field of analytical chemistry detection, and discloses a method and a system for detecting thioctic acid in urine of people based on chromatography-mass spectrometry. The method comprises the following steps: adding a redox buffer system and a metal chelating system into a urine sample, and stabilizing the redox state of lipoic acid under a low-temperature condition; adding a stable isotope internal standard substance into the pretreated sample, and separating and enriching different oxidation-reduction-state compounds based on solvent polarity difference by adopting a liquid-liquid extraction technology; carrying out gradient elution separation by adopting ammonia water system liquid chromatography; simultaneously detecting oxidized lipoic acid and reduced lipoic acid in a tandem mass spectrum multi-reaction monitoring mode; and calculating an oxidation-reduction state concentration ratio by adopting a matrix effect correction algorithm to obtain a metabolic state evaluation index. The technical problem that the detection result is unstable due to the fact that the lipoic acid is in oxidation-reduction state dynamic balance in urine is solved, and the accuracy and comparability of lipoic acid metabolism state evaluation are improved.

This invention discloses a lipid composition, stock solution, preparation method, preparation system, and application for preparing broad-spectrum solvent-compatible liposomes. The lipid composition consists of HSPC, cholesterol, octadecylamine, and vitamin E polyethylene glycol succinate in specific proportions; it is dissolved in an aqueous organic solvent (such as ethanol) to form a lipid stock solution; the preparation system employs a three-channel intelligent control pump; in the preparation method, the above-mentioned lipid stock solution, an aqueous phase containing the target components (which can be pure water to 40% organic solvent-water solution), and a blank aqueous phase are injected into a microfluidic chip to generate a liposome dispersion, which is then purified. This invention overcomes the limitation of solvent polarity on liposome preparation, enabling the stable preparation of high-quality liposomes in a wide range of solvent systems. Experiments have shown that this liposome significantly enhances the stability and transdermal permeability of the encapsulated components, providing a universal, precise, and low-cost delivery platform for encapsulating various active ingredients.

This invention discloses an optically transparent, high-toughness PMMA composite and its preparation method, wherein PMMA-... is prepared in a mass ratio of 1:(60~100):(0.2~0.5):(0.1~0.4). b PCholMA block copolymer, PMMA powder, antioxidant, and nucleating agent are dispersed in a polar solvent, heated, and then cooled to obtain the final product. This invention prepares a PMMA composite containing columnar micelles of block copolymer via a one-step method. By adjusting the solvent polarity, columnar micelles of different lengths can be obtained. The toughness of PMMA composites containing micelles of different lengths is significantly improved. Furthermore, the toughened PMMA retains high transparency. In addition, while significantly improving the mechanical properties of PMMA such as toughness and impact strength, it does not significantly affect the thermal stability, refractive index, Vicat softening point, and glass transition temperature of PMMA, thus broadening the application range of PMMA.

The invention discloses environment-sensitive switch fluorescent nucleosides as well as a preparation method and application thereof, and belongs to the technical field of molecular biology. The environment-sensitive switch fluorescent nucleoside comprises 12 2-amino-2 '-deoxyadenosine substituted by aromatic vinyl at C-8 sites and 7 2'-deoxyisoguanosine derivatives substituted by aryl vinyl at C-8 sites. Through the designed synthesis method, the aromatic vinyl modified environment-sensitive switch fluorescent nucleosides can be obtained with high yield. All the new compounds have fluorescence characteristics and show different degrees of sensitivity to solvent polarity. Wherein the compound 4f and the compound 4e both show high fluorescence quantum efficiency in a non-polar solvent and a polar solvent; the compound 5a and the compound 5b have remarkable fluorescence quantum efficiency in a non-polar solvent, and are expected to be used as switching type fluorescence probes. The compound 5a can be further processed and linked into a deoxyoligonucleotide chain to realize on and off of fluorescence, and the fluorescent nucleosides are suitable for the fields of nucleic acid labeling, fluorescent probes, biomedicine and the like.

The present application relates to the technical field of traditional Chinese medicine extraction and separation, and particularly relates to a method for extracting glycyrrhizin from glycyrrhizin crude product and an extract containing glycyrrhizin prepared by the method. The method comprises the following steps: mixing solvents, adjusting pH value, controlling difference in solvent polarity of an extraction system, controlling extraction temperature, layering, vacuum concentration and spray drying to obtain glycyrrhizin finished product. The present application realizes efficient extraction and enrichment of glycyrrhizin by using purified water, ethyl acetate and n-heptane to form a composite extraction system based on the difference in solvent polarity.

The invention belongs to the field of organic fluorescent materials, and discloses a multifunctional luminescent molecule with excited state intramolecular proton transfer (ESIPT) and aggregation-induced fluorescence emission effects and a preparation method thereof. According to the invention, 2-hydroxybenzothiazole (HBT) is introduced to positions 2 and 7 of a carbazole skeleton, and a p-aniline group is covalently connected to a carbazole N atom, so that the fluorescent molecule with ESIPT and aggregation-induced fluorescence emission effects is prepared. Wherein hydroxyl and amido in the molecular structure are sensitive to solvent polarity and pH. The aniline group in the molecule and formaldehyde are subjected to aldehyde-amine condensation reaction to realize fluorescence response to formaldehyde. The ESIPT molecule provided by the invention has the characteristics of aggregation-induced emission characteristic, large Stokes shift and fluorescence response to acid, alkali and formaldehyde.

The application discloses a kind of high-efficiency composite absorbent for butane oxidation process of maleic anhydride, its characteristics are added to the conventional organic absorbent for maleic anhydride absorption with proper amount of aprotic polar solvent.The aprotic polar solvent has the effect of adjusting solvent polarity, can enhance the weak interaction between organic solvent and maleic anhydride molecule.By optimizing the addition ratio of aprotic polar solvent, both the hydrophobic ability of absorbent can be ensured, and the hydrolysis reaction of maleic anhydride in the absorption process can be avoided, and the absorption capacity of maleic anhydride in butane oxidation reaction gas can be enhanced, the amount of traditional absorbent can be reduced, and the tower load of absorbent recovery unit can be reduced, and the separation energy consumption is reduced.The improved means of the absorbent proposed in the application is simple and effective, can be popularized on a large scale, and has wide application prospect.

The invention relates to a supercritical anti-solvent-electrostatic spray coupling system which comprises a supercritical anti-solvent generation module, a material mixing module and an electrostatic atomization module which are sequentially connected through a connecting pipeline, and a time-space synchronization control module which is in communication connection with the supercritical anti-solvent generation module and the electrostatic atomization module. The space-time synchronous control module cooperatively controls the oscillating electric field and the pressure of the supercritical anti-solvent, so that the electric field jet breaking of the material is realized by the electric field force, and the absolute value of the difference value between the Taylor cone forming time and the supercritical anti-solvent diffusion time is controlled within a set range, so that the supercritical anti-solvent permeates into liquid drops within a millisecond-level time scale; the invention discloses a preparation method of brain-targeted nano-particles, which comprises the following steps: dissolving a solvent in a solvent to trigger a sudden drop effect of polarity of the solvent, so that solute is instantaneously crystallized, and finally a nano-suspension with a particle size of less than 200nm and uniform particle size distribution (PDilt: 0.2) is formed, is suitable for preparing brain-targeted nano-particles with high drug loading capacity and small particle size, and can effectively cross a blood-brain barrier (BBB) to realize continuous and green production.

The invention discloses a side chain substituted triphenylmethyl free radical sensitive to solvent polarity and a preparation method and application thereof, and relates to the technical field of organic light-emitting materials. According to the invention, a triphenylmethyl free radical is used as a receptor, different donors such as 9-phenylcarbazole, 9-phenylcarbazoline, triphenylamine and derivatives thereof are introduced to the meta-position of the triphenylmethyl free radical-receptor through Suzuki reaction, and the conjugation degree between the donors and the receptor is adjusted, so that charge transfer state luminescence of the free radical is realized; the material has specific fluorescence response to solvent polarity, and meanwhile, the light stability of the free radical can be regulated and controlled through the solvent polarity. The invention solves the problem of lack of triphenylmethyl free radicals which are stable in side chain substitution, light-emitting and sensitive to solvent polarity in the prior art.

The invention discloses a coomassie brilliant blue staining solution as well as a preparation method and a staining method thereof. The coomassie brilliant blue staining solution comprises the following components: coomassie brilliant blue, sulfate, inorganic acid, an alcohol solvent, a polar amide solvent and water. The sulfate and the polar amide solvent are introduced into the coomassie brilliant blue staining solution; the sulfate can shorten the dyeing time and reduce the dyeing background; the polar amide solvent can improve the solubility of the coomassie brilliant blue staining solution, so that the staining efficiency and speed are improved, and the detection sensitivity is improved. The protein gel dyeing method is based on the improved coomassie brilliant blue dyeing solution, microwave heating is combined, the whole dyeing process of SDS-PAGE can be completed within 10 minutes, the steps of gel fixation, sensitization, decoloration and the like in a traditional dyeing procedure are omitted, the process steps are simplified, the dyeing time is saved, and the dyeing efficiency is improved. The method has the advantages of fast detection, high sensitivity and small background interference.

The invention belongs to the technical field of extraction and separation, and particularly relates to an extraction method and a detection method of volatile substances in honey. The extraction method comprises the following steps: mixing honey and a buffer solution to obtain a honey pretreatment solution; the honey pretreatment liquid is subjected to ultrasonic extraction by sequentially adopting a polar gradient deep eutectic solvent aqueous two-phase system (such as a deep eutectic solvent which is sequentially mixed with tert-butyl alcohol, isobutanol, n-butyl alcohol, n-propyl alcohol and isopropyl alcohol), and an obtained alcohol upper phase contains volatile substances. According to the method, the characteristics of active ingredients in the honey are combined, a polar gradient deep-eutectic solvent aqueous two-phase extraction system is constructed by utilizing the solvent polarity and similar dissolvability principle, simultaneous separation and enrichment of multiple types of active ingredients are realized, and the method is an efficient and green honey sample pretreatment method. According to the invention, a multi-stage gradient extraction technology is adopted, so that excellent extraction effect and sensitivity are shown; the invention provides a new solution for green extraction of natural products.

The invention discloses a high-dispersity superfine solid electrolyte material and a preparation method thereof.The preparation method comprises the steps that firstly, solid electrolyte coarse powder is dispersed in deionized water, then a high-flash-point and weak-polarity solvent is added into the deionized water, the solid electrolyte powder is promoted to be fully mixed with the deionized water and the weak-polarity solvent in a blending and fine grinding mode, and the high-dispersity superfine solid electrolyte material is obtained; and the weak-polarity mixed slurry is formed. In the process, the particle aggregation phenomenon is inhibited by utilizing a solvent polarity regulation and control mechanism, and the uniformity of the slurry is ensured. And then, carrying out desolvation treatment on the weak-polarity mixed slurry. In the desolvation process, a solute and a solvent in the slurry can be separated to form a wet blocky material. Then, the wet blocky materials are dried, and dried soft agglomerated particles are obtained; and finally, carrying out jet milling treatment on the soft agglomerated particles, further refining the particle size, and finally obtaining high-dispersion nanoscale solid electrolyte powder.

The invention relates to the technical field of biological peptides, and discloses a weight-losing peptide with high activity as well as a preparation method and application thereof, and the weight-losing peptide is prepared from an Arg34-GLP-1 (7-37) main chain, an acylating agent, an N-acetyl-L-arginine chaotropic regulator, a sodium benzoate interface regulator, a zinc salt masking agent and a reaction solvent. The preparation method comprises the following steps: carrying out in-situ coordination masking on the N-terminal of polypeptide by using zinc ions in a water phase, then feeding a reaction solvent to implement solvent polarity switching so as to construct a homogeneous reaction system, then carrying out high-selectivity acylation reaction, and finally carrying out metal decomplexation and deprotection treatment. According to the invention, the technical problems of serious N-terminal competitive side reaction, easy racemization of histidine and easy aggregation and precipitation of polypeptide in a mixed solvent in the modification process are effectively solved by utilizing the synergistic effect of metal coordination locking and a chaotropic regulator, and the obtained product is high in regioselectivity and complete in biological activity.

The application discloses a method for extracting antidepression active Euphausia superba oil by adopting subcritical combination solvent, and belongs to the technical field of deep processing of Euphausia superba. The method is a three-stage gradient extraction method of "subcritical butane-acetone-ethanol", and realizes differential separation and enrichment of lipid components by using solvent polarity difference. The first-stage subcritical butane extraction is carried out under low temperature, closed and oxygen isolation conditions, and high-efficiency desolventizing is realized by using reduced pressure gasification, so that the heat-sensitive active ingredients are effectively reserved, and meanwhile, oxidation and metamorphosis of raw materials are avoided, thereby laying a foundation for preparation of subsequent high-quality extracts. The method successfully prepares three Euphausia superba oil products with significant component differences, and especially, the third-stage extract and the enzymatic modification product thereof exhibit excellent antidepression activity. The application realizes functional separation of Euphausia superba lipid components, and provides strong support for development of personalized and diversified antidepression products.

This invention provides a method for preparing high-purity lithium sulfide using a modified solvent system and a metathesis method, comprising the following steps: S1: Under an inert atmosphere or air atmosphere, weigh lithium chloride and sodium sulfide in a molar ratio of 2:1 and dissolve them in a solvent system; S2: Stir the solution system obtained in S1 to generate lithium sulfide precipitate; S3: After the reaction is complete, separate the reaction system to remove the byproduct sodium chloride and unreacted raw materials, obtaining crude lithium sulfide; S4: Recover the solvent from the solution obtained in S3, and perform low-temperature heat treatment on the crude lithium sulfide under an inert atmosphere to obtain high-purity lithium sulfide. This invention uses an ethanol-isopropanol mixed solvent system, which effectively adjusts the solvent polarity, improves the solubility of LiCl and Na2S, and increases the reaction rate and conversion rate; the introduction of an ionic liquid-assisted solvent system further regulates the nucleation and growth process of Li2S, resulting in more uniform product particle size.

The invention relates to a photooxidation ring-opening-based N, N-disubstituted dihydrophenazine derivative and a preparation method and application thereof.The preparation method comprises the steps that N, N-disubstituted dihydrophenazine shown in the formula (2) is dissolved in an organic solvent, a photooxidation reaction is conducted in the air atmosphere or the oxygen atmosphere under the illumination condition, and the N, N-disubstituted dihydrophenazine derivative shown in the formula (1) is obtained. Compared with the prior art, the preparation method disclosed by the invention is mild in reaction condition, environment-friendly and simple and convenient to operate, the N, N-disubstituted dihydrophenazine derivative has the characteristic of regulating and controlling the spectral performance of the N, N-disubstituted dihydrophenazine derivative through solvent polarity, and the potential application of the N, N-disubstituted dihydrophenazine derivative in the field of functional materials is expanded.

The application discloses a method for synthesizing diphenylamine from aniline. μ -H)3IrCp*][X] (Cp*: pentamethylcyclopentadiene; X: BF4 — , PF6 — , BPh4 — , CF3SO3 — ) as a catalyst, and diphenylamine is obtained under the conditions of a reaction temperature of 100-300 DEG C and a reaction pressure of 0.5-4.0 MPa. The method has high aniline conversion rate and good diphenylamine selectivity, and the catalyst can be recovered through solvent polarity adjustment after the reaction is completed.

The invention discloses a rare earth Eu tetrahedral cage complex and a preparation method and application thereof, and relates to the field of coordination chemistry and supramolecular chemistry, the rare earth Eu tetrahedral cage complex is formed by self-assembly of four europium ions and four beta-diketone ligand derivatives L through coordination bonds, and the composition is Eu4L4; wherein the rare earth Eu tetrahedral cage-shaped complex is of a tetrahedral cage-shaped structure, and the structural formula is shown in the specification. The Eu4L4 tetrahedral cage-shaped complex prepared by the invention shows obvious fluorescence emission in various solvents, the fluorescence intensity is adjustable along with the polarity change of the solvents, the problems that the existing rare earth complex is single in structure, the luminescence property is difficult to regulate and control and the solvent responsiveness is poor are solved, and the Eu4L4 tetrahedral cage-shaped complex has potential application value in the fields of fluorescence sensing and molecular recognition.

The application relates to a quantum dot electronic ink and a preparation method thereof. The quantum dot electronic ink comprises the following components in percentage by weight: 0.1-5% of quantum dot material, 0.1-5% of electronic transmission material, 1-20% of non-polar organic solvent and / or weak polar organic solvent, 60-90% of main solvent and 1-20% of polar organic solvent; wherein the main solvent is a long carbon chain fatty alcohol solvent; the boiling point of the polar organic solvent is greater than that of the non-polar organic solvent and / or weak polar organic solvent, and the boiling point of the main solvent is greater than that of the non-polar organic solvent and / or weak polar organic solvent. The quantum dot electronic ink can form a quantum dot material layer and an electronic transmission layer at one time, and the layer thickness is uniform, so that the steps of QLED device manufacturing are simplified, and the manufacturing efficiency is improved.

This invention belongs to the field of organic fluorescent materials and discloses a multifunctional luminescent molecule exhibiting excited-state intramolecular proton transfer (ESIPT) and aggregation-induced fluorescence emission effects, as well as its preparation method. This invention prepares a fluorescent molecule with ESIPT and aggregation-induced fluorescence emission effects by introducing 2-hydroxybenzothiazole (HBT) at the 2,7 positions of the carbazole backbone and covalently linking a p-aniline group to the N atom of the carbazole. The hydroxyl and amine groups in the molecule are sensitive to solvent polarity and pH. The aniline group in the molecule undergoes an aldehyde-amine condensation reaction with formaldehyde to achieve a fluorescent response to formaldehyde. The ESIPT molecule provided by this invention exhibits aggregation-induced emission characteristics, a large Stokes shift, and fluorescence responses to acids, bases, and formaldehyde.

The invention discloses a boron-containing solid-liquid double-state fluorescent polymer material with solvent polarity responsiveness. The boron-containing solid-liquid double-state fluorescent polymer material with solvent polarity responsiveness can emit light in both solid and liquid states, and after the polymer is dissolved in organic solvents with different polarities, the solution fluorescence can be subjected to red shift along with the increase of the polarity of the solvents and can be subjected to red shift from cyan blue to yellow green. The invention also provides a preparation method of the boron-containing solid-liquid double-state fluorescent high polymer material with solvent polarity responsiveness, the synthesis method is simple in process, convenient to operate and low in cost, the application of the material in the field of fluorescence detection is greatly widened, and the material has a good application prospect on the basis of the unique and sensitive fluorescence response characteristic of the material to the solvent polarity. The fluorescent probe shows relatively important application potential in the fields of fluorescence sensing, chemical detection, microenvironment probes and the like, and is expected to be widely applied to the leading edge directions of environment monitoring, biomedical detection and the like.

The invention discloses a green preparation method of high-crystallinity alcohol precipitation silk protein microspheres, and solves the problems of poor biological safety, inaccurate morphology control, high-temperature denaturation of protein and slow induction rate of a beta-folded crystal structure in the traditional process. The method comprises the following steps: atomizing a purified silk protein solution into uniform liquid drops through electrostatic spraying, spraying liquid nitrogen, instantly freezing, curing and forming, and freezing and drying to form a loose microsphere matrix; and carrying out short-time treatment by using an alcohol solvent, triggering protein molecule rearrangement by using the polarity change of the solvent, and efficiently converting into a beta-folded crystal structure (the crystallinity is greater than or equal to 50%). The size of the microspheres is accurately regulated and controlled through electrostatic spraying parameters, protein denaturation is avoided through liquid nitrogen low-temperature freezing, and the crystallinity and stability are improved through an alcohol precipitation method. The obtained microspheres have excellent mechanical strength and water environment stability, and are suitable for the fields of interventional embolism, non-pressing hemostasis, drug controlled release, tissue engineering and the like.

A method of enriching, by chromatography, intact adeno-associated virus (AAV) capsids from a mixture comprising intact AAV capsids, partially filled and / or empty AAV capsids, comprising the steps of:-contacting the mixture with a strong or weak anion exchange material; eluting the load mixture with a neutral to alkaline buffer comprising an organic modulator having a relative measurement of solvent polarity of 0.4 to 0.8; and-collecting a fraction rich in intact AAV capsids.

The invention discloses a lyochromic probe with high light absorptivity and polarity-enhanced fluorescence as well as a preparation method and application of the lyochromic probe. The molecular structural formula of the probe is shown in the specification. The preparation method comprises the following steps: by taking 2-(2, 6-bis ((E)-2-(dimethylamino) vinyl)-4H-pyran-4-subunit) malononitrile and bis (9, 9-dimethyl-9H-fluorene-2-yl) amine as raw materials, stirring and refluxing under the action of acetic anhydride to obtain a final product crude product; and separating the obtained crude product through thin layer chromatography to obtain the lyochromism probe with high light absorptivity and polarity enhanced fluorescence. The lyochromic probe keeps a high light absorption coefficient of more than 70000 M <-1 > cm <-1 > in a polar solvent; the probe shows high polarity sensitivity and solvatochromism, the fluorescence intensity is gradually enhanced along with the increase of the polarity of the solvent, and the high fluorescence quantum yield in DMSO is higher than 50%. The material can be used for polarity sensing, solvent analysis and temperature monitoring according to the characteristics.