39 results about "Solvent polarity" patented technology

The invention relates to the field of viscosity detection, and provides a fluorescent probe for detecting the viscosity of mask essence as well as a preparation method and application of the fluorescent probe. 4, 4 '-(iminomethylene) bis (N, N-dimethylaniline) which is slightly soluble in water reacts with acid to form auramine hydrochloride, the water solubility of the auramine hydrochloride fluorescent probe is greatly enhanced, the probe in a water phase is converted into heat (non-radiation decay) due to twisted intramolecular charge transfer and excited state energy caused by benzene ring rotation, and fluorescence quenching is shown; when the viscosity of the solvent is increased, rotation of the benzene ring is blocked, excited state energy cannot be converted into heat and is dissipated in a radiation attenuation mode, fluorescence is enhanced, and viscosity detection of the mask essence with the main component being water is achieved based on the principle. According to the present invention, the method has characteristics of simple synthesis, stable property, no interference of solvent polarity during detection, long-term storage and long-term use, rapid and high-specificity viscosity response ability, and quantitative analysis of viscosity.

The invention discloses an illumination cage-removing probe as well as a preparation method and application thereof. The illumination cage-removing probe has a structure as shown in a formula I; the illumination cage removal probe has a very high illumination cage removal rate in a non-polar solvent, and has a very low illumination cage removal rate in a water phase. The solvent polarity-sensitive illumination decaging probe can be used for proximity labeling of lipid droplet surrounding proteins in fatty liver pathological tissue slices. # imgabs0 #

The application relates to the technical field of photovoltaic cells, in particular to a solvent composition, a perovskite thin film and a preparation method thereof and a solar cell. The solvent composition comprises: a main solvent with a boiling point greater than 150 DEG C, the main solvent being selected from at least one of a perfluoroalkane compound and a perfluoro tertiary amine compound; an extraction solvent with a boiling point greater than 150 DEG C, the extraction solvent being selected from at least one of an aromatic ether compound, a halogenated aromatic hydrocarbon compound and an ester compound; and an adjusting solvent with a polarity between the polarities of the main solvent and the extraction solvent. The solvent composition provided by the application realizes mild and controllable extraction through the synergistic effect of the main solvent, the extraction solvent and the adjusting solvent, improves the crystallization quality of the thin film, the temperature of solvent bath annealing treatment can reach above the conversion temperature of the photoactive phase of the perovskite thin film, the phase transition is sufficient, and the photoelectric performance of the device is improved.

The invention discloses a method for detecting sweet-scented osmanthus aroma components in sweet-scented osmanthus wine, which comprises the following steps: diluting a wine sample, adding salt until the wine sample is saturated, and then carrying out liquid-liquid micro-extraction by using a mixed solvent of absolute ether and ethyl acetate in a specific ratio, the volume fraction of the ethyl acetate being 3-5%; after oscillation, ultrasonic-assisted extraction and centrifugal separation, an organic phase is taken for dehydration, a gas chromatograph-mass spectrometer is used for analysis, and an internal standard method is adopted for quantification. By optimizing the polarity of the solvent, various aroma components (such as leaf alcohol, linalool oxide, linalool, ionone, tea aroma spirane and the like) from strong polarity to weak polarity can be effectively covered, and balanced and efficient extraction under a single extraction step is realized. The method is easy and convenient to operate, high in recovery rate, good in reproducibility and suitable for quality evaluation and production process control of the osmanthus fragrans wine.

The invention relates to the technical field of photovoltaic cells, in particular to a solvent composition, a perovskite thin film, a preparation method of the perovskite thin film and a solar cell. The solvent composition comprises: a main solvent, the boiling point of which is greater than 150 DEG C, the main solvent being selected from at least one of a perfluoroalkane compound and a perfluorotertiary amine compound; the boiling point of the extracting solvent is higher than 150 DEG C, and the extracting solvent is selected from at least one of aromatic ether compounds, halogenated aromatic compounds and ester compounds; the polarity of the adjusting solvent is between the polarity of the main solvent and the polarity of the extracting solvent. According to the solvent composition provided by the invention, through the synergistic effect of the main body solvent, the extraction solvent and the adjusting solvent, mild and controllable extraction is realized, the crystallization quality of the film is improved, the temperature of the solvent bath annealing treatment can reach the conversion temperature of the photoactive phase of the perovskite film or above, the phase transformation is sufficient, and the photoelectric property of a device is further improved.

The invention relates to the technical field of analytical chemistry detection, and discloses a method and a system for detecting thioctic acid in urine of people based on chromatography-mass spectrometry. The method comprises the following steps: adding a redox buffer system and a metal chelating system into a urine sample, and stabilizing the redox state of lipoic acid under a low-temperature condition; adding a stable isotope internal standard substance into the pretreated sample, and separating and enriching different oxidation-reduction-state compounds based on solvent polarity difference by adopting a liquid-liquid extraction technology; carrying out gradient elution separation by adopting ammonia water system liquid chromatography; simultaneously detecting oxidized lipoic acid and reduced lipoic acid in a tandem mass spectrum multi-reaction monitoring mode; and calculating an oxidation-reduction state concentration ratio by adopting a matrix effect correction algorithm to obtain a metabolic state evaluation index. The technical problem that the detection result is unstable due to the fact that the lipoic acid is in oxidation-reduction state dynamic balance in urine is solved, and the accuracy and comparability of lipoic acid metabolism state evaluation are improved.

The invention discloses a synthesis method of high-quality phenylacetyl chloride, and belongs to the technical field of synthesis of phenylacetyl chloride. According to the method, the crude phenylacetyl chloride is purified by combining the strong-polarity aprotic solvent dimethyl sulfoxide and the disubstituted ionic liquid, the solvent is strong in polarity, can remove high-polarity colored group impurities, does not contain reactive hydrogen and does not react with phenylacetyl chloride, and the phenylacetyl chloride and the solvent are separated by standing and layering after mixing at normal temperature. A double bond and a benzene ring in the disubstituted ionic liquid can form a pi-pi accumulation effect with macromolecular impurities containing conjugated systems such as oligomers in the impurities, ester groups can form stable hydrogen bonds with strong hydrogen bond donors such as aldehyde groups in the impurities, ether bonds can adsorb thioether impurities, and the adsorption capacity is further enhanced through SbF6 anions. The purity of the phenylacetyl chloride synthesized through the method reaches 99.0% or above through liquid phase analysis, and the phenylacetyl chloride does not change color through high-temperature tests and completely meets the standard of high-quality phenylacetyl chloride.

The invention relates to the field of zeolite imidazole framework materials, in particular to a synthesis method of a zeolite imidazole framework material. The synthesis method of the zeolite imidazole framework material comprises the following synthesis steps: taking a water-based cosolvent, adding a zinc salt, stirring, mixing and collecting to obtain a metal salt mixed solution; 2-methylimidazole is dissolved in deionized water and dropwise added into the mixed solution, after stirring reaction, washing treatment and drying are conducted, and a zeolite imidazole framework material is prepared; the water-based cosolvent is prepared by mixing an alcohol solvent and deionized water according to different volume ratios, and the alcohol solvent comprises one of methanol, ethanol, n-propanol and isopropanol. An alcohol-water aqueous cosolvent system is adopted to replace a traditional organic solvent, and the coordination environment of metal ions and ligands is influenced by regulating and controlling the polarity of the solvent and a hydrogen bond network. The introduction of the alcohol solvent can enhance the deprotonation ability of the ligand and promote the metal-ligand coordination balance to move towards the product direction, and the existence of water reduces the toxicity of the system and improves the environmental friendliness.

This invention discloses a lipid composition, stock solution, preparation method, preparation system, and application for preparing broad-spectrum solvent-compatible liposomes. The lipid composition consists of HSPC, cholesterol, octadecylamine, and vitamin E polyethylene glycol succinate in specific proportions; it is dissolved in an aqueous organic solvent (such as ethanol) to form a lipid stock solution; the preparation system employs a three-channel intelligent control pump; in the preparation method, the above-mentioned lipid stock solution, an aqueous phase containing the target components (which can be pure water to 40% organic solvent-water solution), and a blank aqueous phase are injected into a microfluidic chip to generate a liposome dispersion, which is then purified. This invention overcomes the limitation of solvent polarity on liposome preparation, enabling the stable preparation of high-quality liposomes in a wide range of solvent systems. Experiments have shown that this liposome significantly enhances the stability and transdermal permeability of the encapsulated components, providing a universal, precise, and low-cost delivery platform for encapsulating various active ingredients.

This invention discloses a method for preparing a lysosome-targeted polar fluorescent probe and its application in bioimaging, belonging to the field of chemical analysis and detection technology. The structure of the polar fluorescent probe is as follows: The lysosome-targeted polar fluorescent probe of this invention exhibits excellent polar sensing properties and significant aggregation-induced emission characteristics. With increasing solvent polarity, the fluorescence emission of the probe PHPT shows a significant redshift and a marked increase in fluorescence intensity. Within the polarizability range of 0.214–0.353, the maximum emission wavelength of the probe PHPT shows a good linear relationship with the solvent polarizability. The probe also exhibits good photostability. More importantly, the polarity detection properties of the probe PHPT are unaffected by pH and various small biological molecules. The probe PHPT has low cytotoxicity and is suitable for bioimaging. PHPT has the ability to precisely target lysosomes and can be used to detect decreased cell polarity and increased polarity during autophagy, and can be used to monitor physiological activities related to changes in intracellular polarity.

The invention belongs to the technical field of pharmaceutical chemical crystallization, and particularly relates to tripterine, a crystal form of a solvate of the tripterine, a preparation method and application of the tripterine. The crystal form is a co-crystal of the tripterine and a solvent, and the ratio of the tripterine to the solvent is (45-200) mg: (1-30) mL. And the solvent is selected from C1-C4 alcohol solvents, C3-C5 ester solvents and non-polar solvents. 22 solvates and one novel polymorphic form are prepared by slurry conversion and solvent evaporation methods. The solvate is of a unique channel type structure, and solvent molecules are embedded into a three-dimensional framework constructed by a tripterine hydrogen bond network through hydrogen bonds and Van der Waals interaction. The stability of the crystal obtained by the polar solvent is obviously superior to that of the non-polar solvent, the structure-function relationship among the solvent polarity, the crystal structure and the thermal stability is clarified, and a theoretical basis and experimental guidance are provided for the preparation design of the tripterine medicine.

This invention discloses an optically transparent, high-toughness PMMA composite and its preparation method, wherein PMMA-... is prepared in a mass ratio of 1:(60~100):(0.2~0.5):(0.1~0.4). b PCholMA block copolymer, PMMA powder, antioxidant, and nucleating agent are dispersed in a polar solvent, heated, and then cooled to obtain the final product. This invention prepares a PMMA composite containing columnar micelles of block copolymer via a one-step method. By adjusting the solvent polarity, columnar micelles of different lengths can be obtained. The toughness of PMMA composites containing micelles of different lengths is significantly improved. Furthermore, the toughened PMMA retains high transparency. In addition, while significantly improving the mechanical properties of PMMA such as toughness and impact strength, it does not significantly affect the thermal stability, refractive index, Vicat softening point, and glass transition temperature of PMMA, thus broadening the application range of PMMA.

The invention discloses environment-sensitive switch fluorescent nucleosides as well as a preparation method and application thereof, and belongs to the technical field of molecular biology. The environment-sensitive switch fluorescent nucleoside comprises 12 2-amino-2 '-deoxyadenosine substituted by aromatic vinyl at C-8 sites and 7 2'-deoxyisoguanosine derivatives substituted by aryl vinyl at C-8 sites. Through the designed synthesis method, the aromatic vinyl modified environment-sensitive switch fluorescent nucleosides can be obtained with high yield. All the new compounds have fluorescence characteristics and show different degrees of sensitivity to solvent polarity. Wherein the compound 4f and the compound 4e both show high fluorescence quantum efficiency in a non-polar solvent and a polar solvent; the compound 5a and the compound 5b have remarkable fluorescence quantum efficiency in a non-polar solvent, and are expected to be used as switching type fluorescence probes. The compound 5a can be further processed and linked into a deoxyoligonucleotide chain to realize on and off of fluorescence, and the fluorescent nucleosides are suitable for the fields of nucleic acid labeling, fluorescent probes, biomedicine and the like.

The present application relates to the technical field of traditional Chinese medicine extraction and separation, and particularly relates to a method for extracting glycyrrhizin from glycyrrhizin crude product and an extract containing glycyrrhizin prepared by the method. The method comprises the following steps: mixing solvents, adjusting pH value, controlling difference in solvent polarity of an extraction system, controlling extraction temperature, layering, vacuum concentration and spray drying to obtain glycyrrhizin finished product. The present application realizes efficient extraction and enrichment of glycyrrhizin by using purified water, ethyl acetate and n-heptane to form a composite extraction system based on the difference in solvent polarity.

The invention belongs to the field of organic fluorescent materials, and discloses a multifunctional luminescent molecule with excited state intramolecular proton transfer (ESIPT) and aggregation-induced fluorescence emission effects and a preparation method thereof. According to the invention, 2-hydroxybenzothiazole (HBT) is introduced to positions 2 and 7 of a carbazole skeleton, and a p-aniline group is covalently connected to a carbazole N atom, so that the fluorescent molecule with ESIPT and aggregation-induced fluorescence emission effects is prepared. Wherein hydroxyl and amido in the molecular structure are sensitive to solvent polarity and pH. The aniline group in the molecule and formaldehyde are subjected to aldehyde-amine condensation reaction to realize fluorescence response to formaldehyde. The ESIPT molecule provided by the invention has the characteristics of aggregation-induced emission characteristic, large Stokes shift and fluorescence response to acid, alkali and formaldehyde.

The application discloses a kind of high-efficiency composite absorbent for butane oxidation process of maleic anhydride, its characteristics are added to the conventional organic absorbent for maleic anhydride absorption with proper amount of aprotic polar solvent.The aprotic polar solvent has the effect of adjusting solvent polarity, can enhance the weak interaction between organic solvent and maleic anhydride molecule.By optimizing the addition ratio of aprotic polar solvent, both the hydrophobic ability of absorbent can be ensured, and the hydrolysis reaction of maleic anhydride in the absorption process can be avoided, and the absorption capacity of maleic anhydride in butane oxidation reaction gas can be enhanced, the amount of traditional absorbent can be reduced, and the tower load of absorbent recovery unit can be reduced, and the separation energy consumption is reduced.The improved means of the absorbent proposed in the application is simple and effective, can be popularized on a large scale, and has wide application prospect.

The invention relates to a supercritical anti-solvent-electrostatic spray coupling system which comprises a supercritical anti-solvent generation module, a material mixing module and an electrostatic atomization module which are sequentially connected through a connecting pipeline, and a time-space synchronization control module which is in communication connection with the supercritical anti-solvent generation module and the electrostatic atomization module. The space-time synchronous control module cooperatively controls the oscillating electric field and the pressure of the supercritical anti-solvent, so that the electric field jet breaking of the material is realized by the electric field force, and the absolute value of the difference value between the Taylor cone forming time and the supercritical anti-solvent diffusion time is controlled within a set range, so that the supercritical anti-solvent permeates into liquid drops within a millisecond-level time scale; the invention discloses a preparation method of brain-targeted nano-particles, which comprises the following steps: dissolving a solvent in a solvent to trigger a sudden drop effect of polarity of the solvent, so that solute is instantaneously crystallized, and finally a nano-suspension with a particle size of less than 200nm and uniform particle size distribution (PDilt: 0.2) is formed, is suitable for preparing brain-targeted nano-particles with high drug loading capacity and small particle size, and can effectively cross a blood-brain barrier (BBB) to realize continuous and green production.

The invention discloses a side chain substituted triphenylmethyl free radical sensitive to solvent polarity and a preparation method and application thereof, and relates to the technical field of organic light-emitting materials. According to the invention, a triphenylmethyl free radical is used as a receptor, different donors such as 9-phenylcarbazole, 9-phenylcarbazoline, triphenylamine and derivatives thereof are introduced to the meta-position of the triphenylmethyl free radical-receptor through Suzuki reaction, and the conjugation degree between the donors and the receptor is adjusted, so that charge transfer state luminescence of the free radical is realized; the material has specific fluorescence response to solvent polarity, and meanwhile, the light stability of the free radical can be regulated and controlled through the solvent polarity. The invention solves the problem of lack of triphenylmethyl free radicals which are stable in side chain substitution, light-emitting and sensitive to solvent polarity in the prior art.

The invention discloses a coomassie brilliant blue staining solution as well as a preparation method and a staining method thereof. The coomassie brilliant blue staining solution comprises the following components: coomassie brilliant blue, sulfate, inorganic acid, an alcohol solvent, a polar amide solvent and water. The sulfate and the polar amide solvent are introduced into the coomassie brilliant blue staining solution; the sulfate can shorten the dyeing time and reduce the dyeing background; the polar amide solvent can improve the solubility of the coomassie brilliant blue staining solution, so that the staining efficiency and speed are improved, and the detection sensitivity is improved. The protein gel dyeing method is based on the improved coomassie brilliant blue dyeing solution, microwave heating is combined, the whole dyeing process of SDS-PAGE can be completed within 10 minutes, the steps of gel fixation, sensitization, decoloration and the like in a traditional dyeing procedure are omitted, the process steps are simplified, the dyeing time is saved, and the dyeing efficiency is improved. The method has the advantages of fast detection, high sensitivity and small background interference.

The invention belongs to the technical field of extraction and separation, and particularly relates to an extraction method and a detection method of volatile substances in honey. The extraction method comprises the following steps: mixing honey and a buffer solution to obtain a honey pretreatment solution; the honey pretreatment liquid is subjected to ultrasonic extraction by sequentially adopting a polar gradient deep eutectic solvent aqueous two-phase system (such as a deep eutectic solvent which is sequentially mixed with tert-butyl alcohol, isobutanol, n-butyl alcohol, n-propyl alcohol and isopropyl alcohol), and an obtained alcohol upper phase contains volatile substances. According to the method, the characteristics of active ingredients in the honey are combined, a polar gradient deep-eutectic solvent aqueous two-phase extraction system is constructed by utilizing the solvent polarity and similar dissolvability principle, simultaneous separation and enrichment of multiple types of active ingredients are realized, and the method is an efficient and green honey sample pretreatment method. According to the invention, a multi-stage gradient extraction technology is adopted, so that excellent extraction effect and sensitivity are shown; the invention provides a new solution for green extraction of natural products.

The invention discloses a high-dispersity superfine solid electrolyte material and a preparation method thereof.The preparation method comprises the steps that firstly, solid electrolyte coarse powder is dispersed in deionized water, then a high-flash-point and weak-polarity solvent is added into the deionized water, the solid electrolyte powder is promoted to be fully mixed with the deionized water and the weak-polarity solvent in a blending and fine grinding mode, and the high-dispersity superfine solid electrolyte material is obtained; and the weak-polarity mixed slurry is formed. In the process, the particle aggregation phenomenon is inhibited by utilizing a solvent polarity regulation and control mechanism, and the uniformity of the slurry is ensured. And then, carrying out desolvation treatment on the weak-polarity mixed slurry. In the desolvation process, a solute and a solvent in the slurry can be separated to form a wet blocky material. Then, the wet blocky materials are dried, and dried soft agglomerated particles are obtained; and finally, carrying out jet milling treatment on the soft agglomerated particles, further refining the particle size, and finally obtaining high-dispersion nanoscale solid electrolyte powder.

The invention relates to the technical field of biological peptides, and discloses a weight-losing peptide with high activity as well as a preparation method and application thereof, and the weight-losing peptide is prepared from an Arg34-GLP-1 (7-37) main chain, an acylating agent, an N-acetyl-L-arginine chaotropic regulator, a sodium benzoate interface regulator, a zinc salt masking agent and a reaction solvent. The preparation method comprises the following steps: carrying out in-situ coordination masking on the N-terminal of polypeptide by using zinc ions in a water phase, then feeding a reaction solvent to implement solvent polarity switching so as to construct a homogeneous reaction system, then carrying out high-selectivity acylation reaction, and finally carrying out metal decomplexation and deprotection treatment. According to the invention, the technical problems of serious N-terminal competitive side reaction, easy racemization of histidine and easy aggregation and precipitation of polypeptide in a mixed solvent in the modification process are effectively solved by utilizing the synergistic effect of metal coordination locking and a chaotropic regulator, and the obtained product is high in regioselectivity and complete in biological activity.

The application discloses a method for extracting antidepression active Euphausia superba oil by adopting subcritical combination solvent, and belongs to the technical field of deep processing of Euphausia superba. The method is a three-stage gradient extraction method of "subcritical butane-acetone-ethanol", and realizes differential separation and enrichment of lipid components by using solvent polarity difference. The first-stage subcritical butane extraction is carried out under low temperature, closed and oxygen isolation conditions, and high-efficiency desolventizing is realized by using reduced pressure gasification, so that the heat-sensitive active ingredients are effectively reserved, and meanwhile, oxidation and metamorphosis of raw materials are avoided, thereby laying a foundation for preparation of subsequent high-quality extracts. The method successfully prepares three Euphausia superba oil products with significant component differences, and especially, the third-stage extract and the enzymatic modification product thereof exhibit excellent antidepression activity. The application realizes functional separation of Euphausia superba lipid components, and provides strong support for development of personalized and diversified antidepression products.

The invention belongs to the technical field, and particularly discloses a solvent response optical crystal as well as a preparation method and application thereof. The crystal is of a novel structure with a molecular formula of C30H48Cl9N3Sb2 and belongs to a monoclinic system, the space group is P21 / c, the cell parameters are as follows: a = 9.2515 (6), b = 25.738 (2), c = 17.5757 (14), alpha = 90 degrees, beta = 92.463 (2) degrees and gamma = 90 degrees, and when the crystal is in contact with solvent molecules with different polarities, different luminous color changes are shown. The relationship between the emission peak tuning of the crystal material and the solvent polarity can be divided into three types: the luminescence color is almost unchanged in a weak polar solvent; carrying out luminescence red shift in a moderate polar solvent; the strong polar solvent quenches luminescence. Meanwhile, the material also shows excellent cyclicity, and is expected to be applied to anti-counterfeiting, information security, information encryption and solvent detection directions.

This invention provides a method for preparing high-purity lithium sulfide using a modified solvent system and a metathesis method, comprising the following steps: S1: Under an inert atmosphere or air atmosphere, weigh lithium chloride and sodium sulfide in a molar ratio of 2:1 and dissolve them in a solvent system; S2: Stir the solution system obtained in S1 to generate lithium sulfide precipitate; S3: After the reaction is complete, separate the reaction system to remove the byproduct sodium chloride and unreacted raw materials, obtaining crude lithium sulfide; S4: Recover the solvent from the solution obtained in S3, and perform low-temperature heat treatment on the crude lithium sulfide under an inert atmosphere to obtain high-purity lithium sulfide. This invention uses an ethanol-isopropanol mixed solvent system, which effectively adjusts the solvent polarity, improves the solubility of LiCl and Na2S, and increases the reaction rate and conversion rate; the introduction of an ionic liquid-assisted solvent system further regulates the nucleation and growth process of Li2S, resulting in more uniform product particle size.

The invention relates to a photooxidation ring-opening-based N, N-disubstituted dihydrophenazine derivative and a preparation method and application thereof.The preparation method comprises the steps that N, N-disubstituted dihydrophenazine shown in the formula (2) is dissolved in an organic solvent, a photooxidation reaction is conducted in the air atmosphere or the oxygen atmosphere under the illumination condition, and the N, N-disubstituted dihydrophenazine derivative shown in the formula (1) is obtained. Compared with the prior art, the preparation method disclosed by the invention is mild in reaction condition, environment-friendly and simple and convenient to operate, the N, N-disubstituted dihydrophenazine derivative has the characteristic of regulating and controlling the spectral performance of the N, N-disubstituted dihydrophenazine derivative through solvent polarity, and the potential application of the N, N-disubstituted dihydrophenazine derivative in the field of functional materials is expanded.

The application discloses a method for synthesizing diphenylamine from aniline. μ -H)3IrCp*][X] (Cp*: pentamethylcyclopentadiene; X: BF4 — , PF6 — , BPh4 — , CF3SO3 — ) as a catalyst, and diphenylamine is obtained under the conditions of a reaction temperature of 100-300 DEG C and a reaction pressure of 0.5-4.0 MPa. The method has high aniline conversion rate and good diphenylamine selectivity, and the catalyst can be recovered through solvent polarity adjustment after the reaction is completed.

The invention provides a selective protective reaction method for small organic molecule compounds, and belongs to the technical field of small organic molecule compounds. A protection group selectivity index prediction method is combined with a multi-level reaction path optimization technology of a river bifurcation network algorithm, and a reaction flux distribution coefficient and a reaction activation energy resistance coefficient are used for guiding optimal protection sequence selection; through thermodynamic and dynamic real-time monitoring of a differential scanning calorimetry and an Arrhenius equation and precise solvent polarity gradient regulation and control based on a partition coefficient and a solvent dielectric constant, the reaction completion degree is dynamically evaluated by adopting double indexes of a conductivity change rate and a pH value offset, and column chromatography separation and purification conditions are optimized; the technical problem that the selective protection reaction precision of the polyfunctional organic small molecule compound is not high is solved.

The invention belongs to the technical field of glycosyl substitute liquid detection and analysis, and discloses a natural glycosyl chromophore as well as a preparation method and application thereof. The natural glycosyl chromophore IPIPT is obtained by coupling a natural plant extract 1H-imidazo [4, 5-D] pyridazine-2-amine and a natural sweetening agent L-arabinose, the prepared natural glycosyl chromophore can release a visual optical signal to the change of microcell viscosity, the optical signal intensity is gradually enhanced along with the increase of the microcell viscosity, and the optical signal intensity is gradually enhanced along with the increase of the microcell viscosity. According to the present invention, the glycosyl substitute base solution is convenient to observe and control the thickening degree of the glycosyl substitute base solution in real time, has characteristics of high viscosity sensitivity coefficient and relatively stable chemical structure, is suitable for long-term stable use in the complex glycosyl substitute base solution, has the chromogenic wavelength peak value of 402 nm, has characteristics of typical blue light, bright color, convenient observation, good light stability, good solvent polarity tolerance, and can be widely used in the fields of biochemistry, biochemistry and the like. And the method is suitable for detecting the fluctuation of the micro-area viscosity of the hypersensitive glycosyl substitute base solution.

The invention discloses a rare earth Eu tetrahedral cage complex and a preparation method and application thereof, and relates to the field of coordination chemistry and supramolecular chemistry, the rare earth Eu tetrahedral cage complex is formed by self-assembly of four europium ions and four beta-diketone ligand derivatives L through coordination bonds, and the composition is Eu4L4; wherein the rare earth Eu tetrahedral cage-shaped complex is of a tetrahedral cage-shaped structure, and the structural formula is shown in the specification. The Eu4L4 tetrahedral cage-shaped complex prepared by the invention shows obvious fluorescence emission in various solvents, the fluorescence intensity is adjustable along with the polarity change of the solvents, the problems that the existing rare earth complex is single in structure, the luminescence property is difficult to regulate and control and the solvent responsiveness is poor are solved, and the Eu4L4 tetrahedral cage-shaped complex has potential application value in the fields of fluorescence sensing and molecular recognition.